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    Osprey, FL Commercial Real Estate for Lease

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    Osprey Office/Medical Shell Space
    Updated: Nov 24, 2025
    Osprey Office/Medical Shell Space

    1449 S Tamiami Trail, Osprey, FL 34229

    $12 SF/Yr
    Shell space ready for buildout (Office/Medical/Professional)
    Flexible size: 2,000 SF +/- to 4,000 SF +/-
    Plumbing in place for restrooms/sinks
    Private surface parking lot
    Excellent exterior finishes with impact glass
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    Turnkey Furnished Office Building
    Updated: Jun 2
    Turnkey Furnished Office Building

    130 N Tamiami Trl, Osprey, FL 34229

    Contact for pricing
    ±1,500 SF freestanding office building
    Turnkey, furnished office layout with reception
    4–5 offices plus a conference room
    Includes a restroom
    Year built: 1985
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    Air-Conditioned Flex Space
    Air-Conditioned Flex Space

    858 South Tamiami Trail, Osprey, FL 34229

    Contact for pricing

    Open commercial space with climate control, oversized entry access, and circulation for delivery vehicles.

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    Based on your search, we've compiled 36 Potential Opportunities for your consideration. Besides 3 Active listings in Osprey, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 29 Properties for Sales.

    Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Palmer Ranch Area Office Space
    Palmer Ranch Area Office Space

    8830 S. Tamiami Trail, Sarasota, FL 34238

    $20 SF/Yr
    10,060 sqft

    Office spaces available in well-appointed building with US 41 frontage.

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    Office Space For Lease
    Office Space For Lease

    2420 N Tamiami Trail, Nokomis, FL 34275

    Contact for pricing

    Office space available for rent at 2420 N Tamiami Trail in Nokomis, Florida.

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    Retail Space on Tamiami Trail
    Retail Space on Tamiami Trail

    8756-8780 S Tamiami Trail, Sarasota, FL

    Contact for pricing
    1,610 sqft 4.55 AC lot

    Retail space available for lease on Tamiami Trail.

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    Retail Space in Nokomis Center
    Retail Space in Nokomis Center

    1075-1097 N Tamiami Trl, Nokomis, FL

    Contact for pricing
    4,036 sqft 12.63 AC lot

    Retail space available in a Publix-anchored shopping center.

    View details

    Similar Spaces for Sale in Osprey, FL

    Consider Similar Space for Sale. We found 29 Spaces matching your search parameters.

    Renovated Executive Office Suite
    Renovated Executive Office Suite

    418 S TAMIAMI Trail, Osprey, FL 34229

    $415,000
    1,272 sqft 2.64 AC lot

    Glass-front offices, a conference room, refined finishes, and dedicated storage create a polished professional setting.

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    Office Condominium Suite
    Office Condominium Suite

    3976 Destination Drive Suite 204, Osprey, FL 34229

    $525,000
    1,313 sqft

    The condominium format allows for either owner occupancy or use by a tenant.

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    Move-In Ready Office Suite
    Move-In Ready Office Suite

    3983 Destination Drive, Units 204 & 205, Osprey, FL 34229

    $850,000
    2,410 sqft

    Move-in ready office suite with reception, conference room, multiple private offices, and breakroom.

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    Turnkey Restaurant Space in Osprey
    Turnkey Restaurant Space in Osprey

    3983 Destination Dr, unit A223 & A224, Osprey, FL 34229

    $1,049,000
    2,030 sqft

    Restaurant space in Bay Street Village and Towncenter.

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    Renovated Executive Office Suite
    Renovated Executive Office Suite

    E3-418 S Tamiami Trl, Osprey, FL 34229

    $415,000
    1,272 sqft

    Fully renovated office suite with three private offices, a conference room, and two storage rooms.

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    Retail Storefront Suite
    Retail Storefront Suite

    3976 DESTINATION Dr 102, Osprey, FL 34229

    $409,000
    1,050 sqft

    For sale retail storefront suite in Building 102, suited for businesses seeking a dedicated street-facing retail presence.

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    Renovated Executive Office Suite
    Renovated Executive Office Suite

    418 S TAMIAMI TRAIL #E3, Osprey, FL 34229

    $415,000
    1,272 sqft

    Fully renovated workspace with three private offices, a conference room, kitchen, restroom, and two storage rooms.

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    Osprey Land on Tamiami Trail
    Osprey Land on Tamiami Trail

    2099 S Tamiami Trl, Osprey, FL 34229

    $1,250,000
    1 sqft 2.51 AC lot

    2.51-acre lot zoned OPI, suitable for office/retail/medical.

    View details
    Marina Boat Slip
    Marina Boat Slip

    570 BLACKBURN POINT Road, Osprey, FL 34229

    $149,900
    1.04 AC lot

    Marina staff provide boat-care services and operate seven days a week.

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    Prime Retail Location on Trail
    Prime Retail Location on Trail

    1301 S Tamiami Trail, Osprey, FL 34229

    $2,950,000
    14 sqft

    Commercial land for sale in a prime retail location.

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    Land
    Land

    2301 S Tamiami Trl, Osprey, FL 34229

    $2,850,000
    163,800 sqft

    Commercial land · 163,800 SF

    View details
    Commercial Land with Public Sewer
    Commercial Land with Public Sewer

    2099 S TAMIAMI Trail, Osprey, FL 34229

    $1,250,000
    2.51 AC lot

    OPI-zoned development parcel along South Tamiami Trail with public sewer service.

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    Commercial Land Parcel
    Commercial Land Parcel

    2099 S TAMIAMI Trail, Osprey, FL 34229

    $1,250,000
    2.51 AC lot

    OPI-zoned land with public water and sewer service along a major regional roadway.

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    Osprey Office Condo For Sale
    Osprey Office Condo For Sale

    436 S TAMIAMI TRAIL #C4, Osprey, FL 34229

    $350,000
    1,272 sqft 2.64 AC lot

    Sophisticated office condo in a prime Osprey location.

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    Ground-Floor Storefront Condominium
    Ground-Floor Storefront Condominium

    Osprey, FL 34229

    $562,900
    1,204 sqft 0.28 AC lot

    CG-zoned commercial suite in a mixed-use center with shared parking and storefront signage options.

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    Office Condo with Private Offices
    Office Condo with Private Offices

    C4-436 S Tamiami Trl, Osprey, FL 34229

    $350,000
    1,272 sqft

    Functional professional suite with reception, collaborative work areas, meeting space, kitchenette, and an in-suite restroom.

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    Move-In Ready Osprey Office Space
    Move-In Ready Osprey Office Space

    3976 DESTINATION DRIVE #A411, Osprey, FL 34229

    $1,099,000
    2,314 sqft

    Fully furnished office space in Baystreet Village, Osprey.

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    Dry Boat Storage Marina
    Dry Boat Storage Marina

    570 BLACKBURN POINT Road, Osprey, FL 34229

    $115,000
    1.04 AC lot

    Hurricane-rated dry storage facility with boating services, fuel, maintenance support, and customer amenities.

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    Dry Boat Storage Marina
    Dry Boat Storage Marina

    570 BLACKBURN POINT Road, Osprey, FL 34229

    $109,000
    1.04 AC lot

    Hurricane-rated marina offering staffed dry storage and on-site boating services.

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    Waterfront Mixed-Use Development Site
    Waterfront Mixed-Use Development Site

    135 Bayview Dr, Osprey, FL 34229

    Contact for pricing
    2,957 sqft 5.50 AC lot

    Development site with Gulf and US-41 frontage and a mixed-use hotel, office, and retail plan.

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    Marina Boat Slip
    Marina Boat Slip

    570 BLACKBURN POINT Road, Osprey, FL 34229

    $99,500
    1.04 AC lot

    Professionally staffed marina with dockside utilities, fueling, service amenities, and provisions for boaters.

    View details

    Osprey, FL Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in Osprey, FL with 3 listings featured on our commercial real estate exchange. Estimated lease rates for Commercial real estate in Osprey, FL average $12 SF/Yr.
    Osprey, FL CRE market trends — vacancy, lease rates and price per SF, updated monthly
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