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    Downtown San Francisco, CA Commercial Real Estate for Lease

    311 results
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    San Francisco Commercial Space Available
    $8,000 / Mo
    3,795 SF

    San Francisco Commercial Space Available

    729 Bush St, San Francisco, CA 94108

    Two-story commercial building in Lower Nob Hill for rent.

    • Prime location in Lower Nob Hill, San Francisco, near Union Square and the Financial District
    • Versatile RC‑4 zoning allows for a wide range of commercial uses
    • Rare large 3,781 sq ft lot for the area
    • Excellent transportation access via BART, cable cars, and MUNI
    • Redevelopment potential, including vertical expansion and modern medical build‑outs
    Updated: Dec 30, 2025
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    Prestigious San Francisco Office Space
    $22 SF/Yr
    30,120 SF

    Prestigious San Francisco Office Space

    505 Floors, San Francisco, CA 94111

    Class A Office Suites, Coworking, Financial District

    • Class A office space totaling 30,120 square feet available at 505 Montgomery Street, San Francisco, CA 94111.
    • Currently, 5,970 square feet is available in multiple suites, with spaces divisible down to 10 square feet and up to 5,000 square feet contiguous.
    • Building renovated in 2019, offering 350 suites with city views in the Financial District.
    • Amenities include a marble lobby and on‑site café.
    • Excellent location near major transportation and Fortune 500 companies.
    Updated: Dec 11, 2024
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    Mission Street Creative Office Space
    $49 SF/Yr
    44,800 SF

    Mission Street Creative Office Space

    San Francisco Creative Office, 5,919-6,028 SF Available

    611-615 Mission St, San Francisco, CA 94105
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    Prime San Francisco Office Space
    Contact for pricing
    17,889 SF

    Prime San Francisco Office Space

    Downtown San Francisco Office Suites Available

    22 Battery St, San Francisco, CA 94111
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    550 California St: Premier Office Space
    $36 SF/Yr
    361,537 SF

    550 California St: Premier Office Space

    Class A Office, San Francisco's Financial District

    550 California St, San Francisco, CA 94104
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    Prime San Francisco Office Space
    $30 SF/Yr
    6,000 SF

    Prime San Francisco Office Space

    Executive Suites, Union Square, CA

    212 Sutter St, San Francisco, CA 94108
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    Prime Waterfront Retail Space
    Contact for pricing
    3,997 SF

    Prime Waterfront Retail Space

    San Francisco Restaurant, 3,997 SF

    1300 Battery St, San Francisco, CA 94111
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    Grant Avenue Office Space
    Contact for pricing
    7,196 SF

    Grant Avenue Office Space

    Prime San Francisco Office, Multiple Suites Available

    231 Grant Ave, San Francisco, CA 94108
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    Savoy Building: San Francisco Retail
    Contact for pricing
    50,223 SF

    Savoy Building: San Francisco Retail

    Prime San Francisco retail space available. Multiple units, ample parking.

    2720 Taylor St, San Francisco, CA 94108
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    Sacramento Street Retail Spaces
    Contact for pricing
    3,740 SF

    Sacramento Street Retail Spaces

    Prime San Francisco Retail Opportunity

    819 Sacramento St, San Francisco, CA 94108
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    220 Post St
    Contact for pricing
    16,771 SF

    220 Post St

    Individual retail properties

    220 Post St, San Francisco, CA 94108
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    San Francisco Creative Office Space
    Contact for pricing
    17,138 SF

    San Francisco Creative Office Space

    Boutique Office Building, South Financial District, Flexible Lease Terms

    111 New Montgomery St, San Francisco, CA 94105
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    San Francisco Retail Space Available
    Contact for pricing
    14,470 SF

    San Francisco Retail Space Available

    Prime Mid-Market Retail, 3 Spaces Available

    0 Trinity Pl, San Francisco, CA 94104
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    Nob Hill Retail Space for Lease
    Contact for pricing
    764 SF

    Nob Hill Retail Space for Lease

    764 SF Restaurant Space, Prime Location

    600 Bush St, San Francisco, CA 94108
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    Prestigious San Francisco Office Suites
    $10 SF/Yr
    3,184 SF

    Prestigious San Francisco Office Suites

    Executive & Coworking Spaces Available

    0 1 Sansome St, San Francisco, CA 94104
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    San Francisco Office Space for Lease
    $57 SF/Yr
    28,302 SF

    San Francisco Office Space for Lease

    Prestigious Coworking & Executive Suites

    580 Floors, San Francisco, CA 94104
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    San Francisco Bay Area Office Suites
    Contact for pricing
    10,500 SF

    San Francisco Bay Area Office Suites

    Prime San Francisco Office Space: 1,185-4,364 sq ft.

    88 Davis St, San Francisco, CA 94111
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    San Francisco Retail Space For Lease
    Contact for pricing
    4,500 SF

    San Francisco Retail Space For Lease

    Prime Restaurant/Bar Space Available

    1 Tillman Pl, San Francisco, CA 94108
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    San Francisco Creative Office Space
    $50 SF/Yr
    46,263 SF

    San Francisco Creative Office Space

    Prime Bush Street Office Suites Available

    530 Bush St, San Francisco, CA 94108
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    San Francisco Waterfront Office Space
    $22 SF/Yr
    35,313 SF

    San Francisco Waterfront Office Space

    Prime San Francisco office, flexible layouts.

    1160 Battery St, San Francisco, CA 94111
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    Howard Street Retail Spaces
    Contact for pricing
    698 SF

    Howard Street Retail Spaces

    San Francisco Retail, Two Units Available

    400 Howard St, San Francisco, CA 94105
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    720 California Street
    $33 SF/Yr
    12,042 SF

    720 California Street

    Distribution properties • 12,042 SF

    720 California St, San Francisco, CA 94108
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    Prime Market Street Retail Space
    Contact for pricing
    1,800 SF

    Prime Market Street Retail Space

    San Francisco Restaurant, 1800 SF, Available

    643 Market St, San Francisco, CA 94105
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    Prime San Francisco Office Space
    Contact for pricing
    5,370 SF

    Prime San Francisco Office Space

    Executive Suites, Financial District, 5,370 SF

    332 Pine St, San Francisco, CA 94104
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    Downtown San Francisco, CA Commercial Real Estate Leasing Opportunities Market Analysis

    Explore Commercial Real Estate leasing options in Downtown San Francisco, CA with 331 listings featured on our commercial real estate exchange. The current inventory includes 187,682,485,320 square feet of properties with an estimated lease value of $13,075 /Mo.

    Estimated lease rates for Commercial Real Estate in Downtown San Francisco, CA begin at $1.45 SF/Yr, with an average of $33 SF/Yr and extend to $240 SF/Yr.

    In Downtown San Francisco, CA, current lease rates show:

    • Office Properties & Spaces positioned at $35
    • Office space measuring $35
    • Retail properties assessed at $34
    • Individual retail properties calculated at $35
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    Popular Searches in San Francisco, CA

    Popular Categories

    Most Searched ZIP Codes in San Francisco, CA

    • 94103
    • 94107
    • 94108
    • 94102
    • 94105
    • 94111
    • 94109
    • 94110
    • 94133
    • 94104
    • 94124
    • 94115

    Select Neighborhood

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