Des Peres, MO Office Units for Rent & Lease

Updated: Jul 4

Modern Office Space for Sublease

13421 Manchester Road, Des Peres, MO 63131

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2,000 sqft

Sublease available: 2,000 SF office space
Office space term through 11/30/2028
Building features modern, customizable office spaces with abundant natural light
High‑end finishes and state‑of‑the‑art amenities
Ample parking and professional business environment

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Updated: Nov 22, 2025

Des Peres Office Space Available

13075 Manchester Road, Des Peres, MO 63131

$32.50 SF/Yr

5,630 sqft

5,630 square feet of office space

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Office Space with Updated Lobby

13075 Manchester Rd, Des Peres, MO 63131

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4,817 sqft

Office space with an updated lobby and a sublease term through August 31, 2028.

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Medical Office Space Available

1000 Des Peres Rd, Des Peres, MO

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13,515 sqft 5.87 AC lot

Medical office space for lease in Des Peres, Missouri.

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Based on your search, we've compiled 8 Potential Opportunities for your consideration. Besides 4 Active listings in Des Peres, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities

Office Units for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Office Space with Corporate Finishes

1 Cityplace Drive, Creve Coeur, MO 63141

$17.50 SF/Yr

28,781 sqft

Office space available for sublease with corporate finishes and amenities.

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Creve Coeur Office Space

6 Cityplace Drive, Creve Coeur, MO 63141

$32.50 SF/Yr

17,552 sqft

Office space available for lease in Creve Coeur, Missouri.

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Class A Atrium Office Suites

Saint Louis, MO 63131

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1,005 sqft

Multiple office suites are available in a Class A atrium office building within Bel Aire Office Park.

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Office and Retail Space Available

Saint Louis, MO 63122

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Office and retail suites in Warson Woods location.

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Des Peres, MO Office Units Lease Rates & Market Statistics

Explore 4 Office Units for lease in Des Peres, MO on Realmo, a commercial real estate exchange covering the Des Peres area. The current inventory totals 25,962 square feet of properties.

Office Units lease rates in Des Peres range from $32.50 SF/Yr at the entry level to $32.50 SF/Yr at the top of the market, averaging $32.50 SF/Yr. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $32.50 SF/Yr is 25% above the Missouri state average of $26.10 SF/Yr.

Des Peres accounts for 1% of the 278 office units currently available across St. Louis County, where nearby markets include Saint Louis and Chesterfield. Office Units are one of the more limited space types in Des Peres, with just 4 listings currently available — a scarcity worth factoring into lease negotiations.