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    Port Saint Lucie, FL Office Units for Lease

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    Miami, FL Orlando, FL Jacksonville, FL
    12 results
    Port St. Lucie Flex Building
    $14 SF/Yr
    48,720 SF

    Port St. Lucie Flex Building

    651 NW Enterprise Dr, Port Saint Lucie, FL 34986

    Industrial flex building with air-conditioned office space for lease.

    • Prime location in Saint Lucie West industrial park with quick access to I‑95 and Florida Turnpike.
    • Excellent condition, newly painted buildings, and resurfaced parking lot.
    • 18’ clear height with 10'x12' roll‑up doors.
    • Air‑conditioned office space in each unit.
    • 3‑phase power, 220 amps.
    Updated: Nov 21, 2025
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    Port St. Lucie Office Space
    $27 SF/Yr
    2,500 SF

    Port St. Lucie Office Space

    155 SW Port St Lucie Blvd, Port Saint Lucie, FL

    2,500 SF office space in a thriving commercial corridor.

    • Prime 2,500 SF space suitable for healthcare, professional services, or administrative offices.
    • Excellent frontage on SW Port St. Lucie Blvd. in a prominent building.
    • Located in a thriving commercial corridor with municipal offices, retail, dining, and professional services.
    • Anchored by Great Smile Dental Group.
    • Interior features multiple office spaces, lobby area, kitchen, and restrooms.
    Updated: Apr 25, 2025
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    St Lucie West Professional Offices
    $25 SF/Yr
    3,076 SF

    St Lucie West Professional Offices

    Medical and professional offices in the heart of St Lucie West.

    525 NW Lake Whitney Pl, Port Saint Lucie, FL
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    St. Lucie West Office Space
    $23 SF/Yr
    45,416 SF

    St. Lucie West Office Space

    Professional and Medical office space in landmark building for lease.

    1660 SW St. Lucie West Blvd, Port Saint Lucie, FL 34986
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    Port Saint Lucie Office Space
    $13 SF/Yr
    13,029 SF

    Port Saint Lucie Office Space

    Office space available for lease in Port Saint Lucie, FL.

    900 E Prima Vista Blvd, Port Saint Lucie, FL
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    Port St. Lucie Office Space
    $18 SF/Yr
    3,753 SF

    Port St. Lucie Office Space

    Versatile office space in a high-traffic Port St. Lucie location.

    7664 S US Hwy 1, Port Saint Lucie, FL
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    Retail, Office, Medical Space Available
    $36 SF/Yr
    1,184 SF

    Retail, Office, Medical Space Available

    New retail, office, and medical space for rent.

    1449-1479 SW Gatlin Blvd, Port Saint Lucie, FL
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    Office Space For Rent
    $22 SF/Yr
    1,629 SF

    Office Space For Rent

    Office space available for lease in Port Saint Lucie, FL.

    1631 NW St Lucie West Blvd, Port Saint Lucie, FL
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    Furnished Office Space Available
    $15 SF/Yr
    5,111 SF

    Furnished Office Space Available

    Professional office space with multiple configurations, fully furnished and equipped.

    526 SW Port St Lucie Blvd, Port Saint Lucie, FL
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    Professional Office Space For Lease
    $900/Mo
    700 SF

    Professional Office Space For Lease

    Two-story office building with recent renovations and ample parking.

    550 SE Port St Lucie Blvd, Port Saint Lucie, FL
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    Port Saint Lucie Office Space
    $22 SF/Yr
    8,500 SF

    Port Saint Lucie Office Space

    Office space available for lease in Port Saint Lucie.

    584 NW University Blvd, Port Saint Lucie, FL
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    Single-Story Office Building For Rent
    $22 SF/Yr
    4,020 SF

    Single-Story Office Building For Rent

    Single-story office building with immediate availability and hurricane impact glass.

    120-128 SW Chamber Ct, Port Saint Lucie, FL
    View details
    Based on your search, we've compiled 16 Potential Opportunities for your consideration. Besides 12 Active listings in Port Saint Lucie, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities

    Explore Office Units for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Medical Office Space on Lake
    $26 SF/Yr
    1,958 SF

    Medical Office Space on Lake

    Single-story medical office with lake views and recent upgrades.

    Fort Pierce, FL 34986
    View details
    Office Space Available For Rent
    Contact for pricing
    2,750 SF

    Office Space Available For Rent

    Office space available for rent in Port St. Lucie, FL.

    Fort Pierce, FL 34986
    View details
    Executive Office Suites For Rent
    $500/Mo

    Executive Office Suites For Rent

    Executive office suites available for lease in Port St. Lucie.

    951 SW Country Club Dr, Port St Lucie, FL
    View details
    Industrial Flex Building For Rent
    Contact for pricing

    Industrial Flex Building For Rent

    Small bay industrial flex building with conversion potential.

    Port St Lucie, FL 34984
    View details

    Port Saint Lucie, FL Office Units Leasing Opportunities Market Analysis

    Explore Office Units leasing options in Port Saint Lucie, FL with 12 listings featured on our commercial real estate exchange. The current inventory includes 137,638 square feet of properties with an estimated lease value of $253 SF/Yr.

    Estimated lease rates for Office Units in Port Saint Lucie, FL begin at $13 SF/Yr, with an average of $21 SF/Yr and extend to $36 SF/Yr.
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