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    Woodruff, SC Office Properties & Spaces for Sale

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    Columbia, SC Aiken, SC Greenville, SC
    Renovated Victorian Estate with Commercial Potential
    $639,900
    4,900 SF

    Renovated Victorian Estate with Commercial Potential

    515 North Main Street, Woodruff, SC 29388

    Grand 7BR/7.5BA Victorian, fully renovated, suitable for various commercial uses.

    • Fully Renovated 7BR/7.5BA Victorian Estate with over 4900 sq ft.
    • Commercial Potential: Suitable for luxury residence, boutique inn, professional office, or event venue.
    • Includes an additional lot, totaling .96 acres, for ample parking or outdoor venue space.
    • Brand new roof, windows, tankless hot water system, cabinets, and vinyl siding (most completed in 2022).
    • Each bedroom has a private ensuite bathroom.
    Updated: Sep 3, 2025
    View details
    Highway 221 Development Opportunity
    $175,000
    2,792 SF

    Highway 221 Development Opportunity

    12117 Highway 221, Woodruff, SC 29388

    2,792 SF building on heavily traveled Highway 221.

    • Prime location in the thriving Woodruff growth area with high traffic frontage on Highway 221.
    • Significant development potential with 2,792 SF building suitable for multiple uses (subject to zoning).
    • Ample room for expansion and over 200' of frontage.
    • Partially renovated with new HVAC ductwork, updated electrical components, and new windows.
    • Multiple points of ingress/egress and ample parking.
    Updated: Mar 17, 2025
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    Based on your search, we've compiled 44 Potential Opportunities for your consideration. Besides 2 Active listings in Woodruff, SC, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 34 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Downtown Fountain Inn Commercial Space
    $1,500,000
    0.59 Acres

    Downtown Fountain Inn Commercial Space

    Prime location with potential for various business uses.

    203 S Weston Street, Fountain Inn, SC 29644
    View details
    Retail/Office Opportunity in Fountain Inn
    Contact for pricing
    13,421 SF

    Retail/Office Opportunity in Fountain Inn

    Retail/office space for sale in downtown Fountain Inn, SC.

    129 North Main Street, Fountain Inn, SC 29644
    View details
    Historic Mill Office Space Available
    Contact for pricing
    8,082 SF

    Historic Mill Office Space Available

    Office space in a renovated historic textile mill.

    300 S St, Simpsonville, SC
    View details
    Simpsonville Commercial Building For Sale
    $3,995,000
    24,000 SF

    Simpsonville Commercial Building For Sale

    24,000 SF building in Simpsonville, SC, renovated in 2013.

    313 N Main St, Simpsonville, SC 29681
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Acreage in Booming Reidville
    $1,844,500
    21.95 Acres

    Prime Acreage in Booming Reidville

    21.95 acres in a prime, rapidly developing location.

    0 S Hammett Road, Woodruff, SC 29388
    View details
    Prime Location Acreage Opportunity
    $1,844,500
    21.70 Acres

    Prime Location Acreage Opportunity

    21.7 acres near Reidville Town Center.

    0 S Hammett Road, Woodruff, SC 29388
    View details
    Simpsonville Commercial Site Available
    $873,910
    2.81 Acres

    Simpsonville Commercial Site Available

    2.81 acre commercial site in Simpsonville, South Carolina.

    Harrison Bridge Road, Simpsonville, SC 29680
    View details
    Simpsonville Commercial Land Opportunity
    $4,750,000
    15.60 Acres

    Simpsonville Commercial Land Opportunity

    15+ acres of commercial land near Fairview Road corridors.

    602 Harrison Bridge Road, Simpsonville, SC 29680
    View details

    Explore Off-Market Properties in Woodruff, SC

    Consider similar Off-Market properties in Woodruff, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    601 Georgia St

    601 Georgia St

    MEDICAL BUILDING • 3,515 SF
    Value Estimation by Request
    601 Georgia St, Woodruff, SC 29388-1953
    View details
    209 Main St

    209 Main St

    OFFICE BUILDING • 1,250 SF
    Value Estimation by Request
    209 Main St, Woodruff, SC 29388-1851
    View details
    241 Main St

    241 Main St

    OFFICE BUILDING • 896 SF
    Value Estimation by Request
    241 Main St, Woodruff, SC 29388
    View details
    3805 Hwy 417

    3805 Hwy 417

    OFFICE BUILDING • 1,745 SF
    Value Estimation by Request
    3805 Hwy 417, Woodruff, SC 29388-8683
    View details
    210 Gregory St

    210 Gregory St

    OFFICE BUILDING • 1,576 SF
    Value Estimation by Request
    210 Gregory St, Woodruff, SC 29388-2207
    View details
    100 Medical Ctr Dr

    100 Medical Ctr Dr

    MEDICAL BUILDING • 5,096 SF
    Value Estimation by Request
    100 Medical Ctr Dr, Woodruff, SC 29388-8704
    View details
    238 Main St

    238 Main St

    OFFICE BUILDING • 1,204 SF
    Value Estimation by Request
    238 Main St, Woodruff, SC 29388-1848
    View details
    122 Main St

    122 Main St

    OFFICE BUILDING • 1,495 SF
    Value Estimation by Request
    122 Main St, Woodruff, SC 29388-1846
    View details
    360 Sloan Rd

    360 Sloan Rd

    OFFICE BUILDING • 3,080 SF
    Value Estimation by Request
    360 Sloan Rd, Woodruff, SC 29388-9041
    View details
    134 Main St

    134 Main St

    OFFICE BUILDING • 1,720 SF
    Value Estimation by Request
    134 Main St, Woodruff, SC 29388-1850
    View details
    315 Main St

    315 Main St

    MEDICAL BUILDING • 4,690 SF
    Value Estimation
    $580,000
    315 Main St, Woodruff, SC 29388-1648
    View details
    101 Carlton Duvall Dr

    101 Carlton Duvall Dr

    OFFICE BUILDING • 1,500 SF
    Value Estimation by Request
    101 Carlton Duvall Dr, Woodruff, SC 29388-8788
    View details
    1114 Georgia Rd

    1114 Georgia Rd

    MEDICAL BUILDING • 29,000 SF
    Value Estimation
    $3,000,000
    1114 Georgia Rd, Woodruff, SC 29388-9350
    View details
    310 Woodruff St

    310 Woodruff St

    OFFICE BUILDING • 1,638 SF
    Value Estimation by Request
    310 Woodruff St, Woodruff, SC 29388-1540
    View details
    316 Main St

    316 Main St

    OFFICE BUILDING • 1,566 SF
    Value Estimation by Request
    316 Main St, Woodruff, SC 29388-1649
    View details
    Pearson St

    Pearson St

    OFFICE BUILDING • 2,160 SF
    Value Estimation by Request
    Pearson St, Woodruff, SC 29388
    View details
    100 Eastland Dr

    100 Eastland Dr

    OFFICE BUILDING • 825 SF
    Value Estimation by Request
    100 Eastland Dr, Woodruff, SC 29388-2325
    View details
    416 Main St

    416 Main St

    MEDICAL BUILDING • 1,164 SF
    Value Estimation by Request
    416 Main St, Woodruff, SC 29388-2117
    View details
    251 Hayne St

    251 Hayne St

    MEDICAL BUILDING • 7,034 SF
    Value Estimation
    $730,000
    251 Hayne St, Woodruff, SC 29388-1921
    View details
    841 Main St

    841 Main St

    OFFICE BUILDING • 1,080 SF
    Value Estimation by Request
    841 Main St, Woodruff, SC 29388-8807
    View details
    420 Main St

    420 Main St

    MEDICAL BUILDING • 1,927 SF
    Value Estimation by Request
    420 Main St, Woodruff, SC 29388-2117
    View details
    1670 Cross Anchor Rd

    1670 Cross Anchor Rd

    OFFICE BUILDING • 2,250 SF
    Value Estimation by Request
    1670 Cross Anchor Rd, Woodruff, SC 29388-9530
    View details

    Woodruff, SC Office Properties & Spaces Investment Opportunities Market Analysis

    Explore 36 office properties & spaces for sale in Woodruff, SC on our real estate platform. These investment opportunities span a total of 7,692 square feet of properties for sale, with an estimated market value of $814,900.

    Sale prices for office spaces in Woodruff, SC start at $175,000, averaging $407,450, and reaching up to $639,900 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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