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Santee, SC Office Spaces for Sale

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Vance, SC Summerton, SC Elloree, SC Holly Hill, SC Eutawville, SC Cameron, SC Bowman, SC Manning, SC
Commercial Building with Self-Storage Units
Updated: Jul 1, 2025
Commercial Building with Self-Storage Units

9158 Old Number Six Highway, Santee, SC 29142

$1,900,000
3,282 sqft 1.00 AC lot
Commercial building built to accommodate two separate businesses, with a second story for offices or storage
Rear includes 22 storage units currently rented for full‑time use
Located about 2,500 linear feet from Hwy 195 on Highway 6 at the corner to Somerset homes and across from the entrance to Santee‑Cooper Resort
Frame construction with vinyl flooring and a basement
Heating: electric (heating); cooling: heat pump
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Based on your search, we've compiled 37 Potential Opportunities for your consideration. Besides 1 Active listings in Santee, SC, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 28 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

General Commercial Duplex with Garage
General Commercial Duplex with Garage

48 W Huggins Street, Manning, SC 29102

$295,000
1,612 sqft 0.41 AC lot

Fully leased duplex plus a detached garage with office space on a highly visible corner lot near downtown Manning.

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Duplex with Detached Office Garage
Duplex with Detached Office Garage

48 W Huggins Street, Manning, SC 29102

$295,000
1,612 sqft 0.41 AC lot

Corner-lot duplex plus detached garage with office space on general commercial zoning for flexible business or rental use.

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Office and Garage Corner Property
Office and Garage Corner Property

212 Main Street, Summerton, SC 29148

$42,000
1,250 sqft 0.06 AC lot

Corner commercial space with finished office rooms, half bath, and an attached rear garage.

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Renovated Multi-Use Building For Sale
Renovated Multi-Use Building For Sale

1 Cantey St, Summerton, SC 29148

$235,000
4,019 sqft 1.00 AC lot

Two-story, renovated multi-use building on a one-acre corner lot.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Two Acres on Divided Highway
Two Acres on Divided Highway

421 S Hwy 4 & Hwy 301, Orangeburg, SC 29115

$400,000
2.00 AC lot

Two acres zoned general commercial on Highway 4 & 301.

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Cleared Lot on Highway 17-A
Cleared Lot on Highway 17-A

231 S Live Oak Drive, Moncks Corner, SC 29461

$200,000
0.47 AC lot

Cleared 0.47 acre lot with road frontage in Moncks Corner.

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General Commercial Zoned Land Parcel
General Commercial Zoned Land Parcel

3291 Broad Street, Sumter, SC 29150

$1,250,000
11.00 AC lot

Commercial frontage in front of Crowndale Subdivision, zoned General Commercial with depth to approximately 300 feet.

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Moncks Corner Land For Sale
Moncks Corner Land For Sale

220 N Highway 52, Moncks Corner, SC 29461

$395,000
5.00 AC lot

5 acres on Hwy 52, Moncks Corner. Priced to sell.

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Off-Market Properties in Santee, SC

Consider similar Off-Market properties in Santee, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

8842 Old Number 6th Hwy
OFFICE BUILDING

8842 Old Number 6th Hwy, Santee, SC 29142

Value Estimation by Request
1,003 sqft 0.41 AC lot
View details
8779 Old Number 6th Hwy
OFFICE BUILDING

8779 Old Number 6th Hwy, Santee, SC 29142

$650,000
Estimated value
1,944 sqft 0.30 AC lot
View details
Hwy 301
OFFICE BUILDING

Hwy 301, Santee, SC 29142

Value Estimation by Request
3,948 sqft 1.02 AC lot
View details
8818 Old Number 6th Hwy
OFFICE BUILDING

8818 Old Number 6th Hwy, Santee, SC 29142-8645

Value Estimation by Request
2,228 sqft 1.00 AC lot
View details
228 Bradford Blvd
MEDICAL BUILDING

228 Bradford Blvd, Santee, SC 29142-8677

$1,870,000
Estimated value
8,425 sqft 1.58 AC lot
View details
8812 Old Number 6th Hwy
OFFICE BUILDING

8812 Old Number 6th Hwy, Santee, SC 29142

Value Estimation by Request
2,400 sqft 0.40 AC lot
View details
Santee, SC 29142
OFFICE BUILDING

Santee, SC 29142

Value Estimation by Request
3,742 sqft 0.50 AC lot
View details
Hwy 30115
OFFICE BUILDING

Hwy 30115, Santee, SC 29142

Value Estimation by Request
5,494 sqft 1.81 AC lot
View details
2247 State Park Rd
OFFICE BUILDING

2247 State Park Rd, Santee, SC 29142-9483

Value Estimation by Request
1,860 sqft 0.49 AC lot
View details
9355 Old Number 6th Hwy
OFFICE BUILDING

9355 Old Number 6th Hwy, Santee, SC 29142-8874

Value Estimation by Request
3,212 sqft 2.30 AC lot
View details
7607 5th Chop Rd
OFFICE BUILDING

7607 5th Chop Rd, Santee, SC 29142

Value Estimation by Request
1,253 sqft 1.20 AC lot
View details
1624 Purina Ln
OFFICE BUILDING

1624 Purina Ln, Santee, SC 29142

Value Estimation by Request
1,600 sqft 1.10 AC lot
View details
2344 Bonner Ave
OFFICE BUILDING

2344 Bonner Ave, Santee, SC 29142-8909

Value Estimation by Request
804 sqft 697.10 AC lot
View details
679 Bass Dr
OFFICE BUILDING

679 Bass Dr, Santee, SC 29142-8797

Value Estimation by Request
800 sqft 0.80 AC lot
View details
Santee, SC 29142
OFFICE BUILDING

Santee, SC 29142

Value Estimation by Request
3,282 sqft 0.59 AC lot
View details
1948 Bass Dr
OFFICE BUILDING

1948 Bass Dr, Santee, SC 29142-8982

Value Estimation by Request
1,028 sqft 2.80 AC lot
View details
9151 Old Number 6th Hwy
OFFICE BUILDING

9151 Old Number 6th Hwy, Santee, SC 29142

Value Estimation by Request
1,327 sqft 1.20 AC lot
View details
8799 Old Number 6th Hwy
MEDICAL BUILDING

8799 Old Number 6th Hwy, Santee, SC 29142-9087

Value Estimation by Request
3,580 sqft 0.90 AC lot
View details
111 John Lawson Ave
MEDICAL BUILDING

111 John Lawson Ave, Santee, SC 29142-8654

Value Estimation by Request
4,520 sqft 3.30 AC lot
View details
119 Intracoastal Ln
OFFICE BUILDING

119 Intracoastal Ln, Santee, SC 29142-8869

Value Estimation by Request
960 sqft 9.30 AC lot
View details
Bass Dr
OFFICE BUILDING

Bass Dr, Santee, SC 29142

Value Estimation by Request
3,025 sqft 2.10 AC lot
View details
Santee, SC 29142
OFFICE BUILDING

Santee, SC 29142

Value Estimation by Request
2,000 sqft 0.85 AC lot
View details
Side Hwy
OFFICE BUILDING

Side Hwy, Santee, SC 29142

Value Estimation by Request
2,400 sqft 2.00 AC lot
View details

Santee, SC Office Spaces Market Trends and Statistics

Explore 29 office spaces for sale in Santee, SC on our real estate platform. These investment opportunities span a total of 3,282 square feet of properties for sale, with an estimated market value of $1,900,000.

Sale prices for office spaces in Santee, SC average $1,900,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Top Commercial Asset Segments

Commercial property segments ranked by active listings on the market

Office Units 1

Demographics Overview

Population 4,658
Population Growth (5Y) -10.2%
Median Household Income $50,673
College Educated 32.1%

Listings Trend

New vs delisted commercial listings in Orangeburg County

New Delisted

Total CRE Inventory on Market (SF)

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