Greenville, SC Office Properties & Spaces for sale

Downtown Greenville Office Space Available

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1.00 Acre

Downtown Greenville Office Space Available

1010 E North St, Greenville, SC 29601

Office suites available in downtown Greenville, utilities included.

Downtown location
Rent includes utilities and maintenance
Other suites available, offering potential for expansion or downsizing
Natural Gas Heating
Electric Cooling

Updated: Jul 18, 2025

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Greenville Office Near Medical Facilities

$950,000

0.35 Acres

Greenville Office Near Medical Facilities

101 Chapman St, Greenville, SC 29605

Premium office space with subdivision potential near Prisma Health.

Premium office space in a desirable location
Sub‑dividable units suitable for single or multiple tenants
Directly across from Prisma Health and USC Medical University
Generous parking available
Benefit from 10' ceilings

Updated: Nov 24, 2025

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0.12 Acres

Refreshed Office Building in Greenville

Refreshed commercial office building in a prime Greenville location.

604 University Rdg, Greenville, SC 29601

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0.44 Acres

Professional Office Suite on Pelham

First floor office suite available for sublease through February 2029.

330B Pelham Rd, Greenville, SC 29615

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$60,000

0.43 Acres

Historic Firehouse Office Space

Office space in downtown Greenville's Central Business District.

508 Rhett St, Greenville, SC 29601

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0.10 Acres

Greenville Office Space Available

Office space in thriving Greenville location near downtown.

1322 E Washington St, Greenville, SC 29607

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$389,900

0.34 Acres

Greenville Commercial Building For Sale

Commercial building in high traffic area suitable for various uses.

1 Elizabeth Dr, Greenville, SC 29615

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Eastside Greenville Office Space Available

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0.10 Acres

Eastside Greenville Office Space Available

Well-maintained office space in a desirable Greenville location.

4010 E North St, Greenville, SC 29615

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$935,000

0.25 Acres

Office For Sale Greenville

Office property available for purchase in Greenville, South Carolina.

204 Mills Ave, Greenville, SC 29605

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$398,500

0.47 Acres

Serviceable Office in Greenville, SC

Office building for sale with billboard income in Greenville.

1908 N Pleasantburg Dr, Greenville, SC 29609

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$2,750,000

16,778 SF

Downtown Greenville Office Complex

Prime Greenville location, two office buildings.

429 N Main St, Greenville, SC 29601

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$4,200,000

16,778 SF

Downtown Greenville Mixed-Use Gem

Prime location, redevelopment opportunity.

429 Main St, Greenville, SC 29601

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$2,750,000

6,888 SF

Prime Greenville Executive Offices

Two buildings, high visibility, downtown location

429 Main St, Greenville, SC 29601

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$1,500,000

2,500 SF

Greenville Office Building For Sale

Prime Greenville location, 2,500 sq ft office/retail space.

103 Wade Hampton Blvd, Greenville, SC 29609

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$7,000,000

20,000 SF

Downtown Greenville Office Building

Prime Office Investment, High NOI

120 Broadus Ave, Greenville, SC 29601

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Greenville Office Redevelopment Opportunity

$1,750,000

9,609 SF

Greenville Office Redevelopment Opportunity

9,609 SF Office Building, Prime Location

217 Stone Ave, Greenville, SC 29609

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$800,000

3,200 SF

Greenville Mixed-Use Investment

3,200 SF, 2 Units, Redevelopment Opportunity

310 Rutherford St, Greenville, SC 29609

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$900,000

3,696 SF

Greenville Executive Office Building

Prime Greenville location, multi-tenant office.

506 Pettigru St, Greenville, SC 29601

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$200,000

1,232 SF

West Greenville Office For Sale

Office building in West Greenville's San Souci Community.

4003 Old Buncombe Rd, Greenville, SC 29617

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$2,395,000

7,397 SF

Medical Office Building For Sale

Two-story, ±7,397 SF medical office building suited for owner-occupant.

300 Regent Park Ct, Greenville, SC 29607

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$6,789,142

34,284 SF

Office Building For Sale

Office building with lease income available for sale.

426 Fairforest Way, Greenville, SC 29607

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$825,000

7,000 SF

Greenville Office Building For Sale

Office building with 7,000 square feet of space.

10 Memorial Medical Dr, Greenville, SC 29605

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$2,950,000

6,291 SF

Main Street Mixed-Use Opportunity

Three-story building with retail, office, and residential spaces.

225 N Main St, Greenville, SC 29605

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$499,000

2,384 SF

Greenville Office with Private Restroom

Office space near downtown Greenville with private offices and parking.

106 S Texas Ave, Greenville, SC 29611

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Greenville, SC Office Properties & Spaces Investment Opportunities Market Analysis

Explore 1779 office properties & spaces for sale in Greenville, SC, showcased through 42 active listings on our real estate platform. These investment opportunities span a total of 776,774,062 square feet of properties for sale, with an estimated market value of $874,489,550.

Prices for office spaces in Greenville, SC start at $60,000, averaging $959,922, and reaching up to $23,660,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you have the most current data.

Greenville, SC Office Properties & Spaces for Sale

Downtown Greenville Office Space Available

Office suites available in downtown Greenville, utilities included.