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    Portsmouth, OH Office Properties & Spaces for Sale

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    Cleveland, OH Columbus, OH Cincinnati, OH
    Downtown Portsmouth Commercial Building For Sale
    $525,000
    5,526 SF

    Downtown Portsmouth Commercial Building For Sale

    317 CHILLICOTHE, Portsmouth, OH 45662

    High-visibility commercial building with development potential in historic downtown Portsmouth.

    • High‑visibility location in the heart of historic downtown.
    • Versatile property with development potential on the wide‑open second floor.
    • Basement with 9‑foot ceilings and over 2,500 sq ft of usable space.
    • Recent upgrades include 16 tons of commercial A/C, new 3‑phase electrical, updated plumbing, and new windows.
    • Large display windows, high ceilings, and an open layout.
    Updated: Jan 6
    View details
    Versatile Commercial Property in Portsmouth
    $264,500
    2,208 SF

    Versatile Commercial Property in Portsmouth

    826 Gay St., Portsmouth, OH 45662

    High-visibility commercial property with versatile layout and living space.

    • Highly visible corner location across from Kroger, offering exceptional exposure.
    • Versatile layout suitable for various business uses (small business, office, meeting area).
    • On‑site parking for customers and employees.
    • Potential for a drive‑through business due to corner lot access from two streets.
    • Upstairs living space provides option to live where you work or rent for income.
    Updated: Mar 4
    View details
    Commercial Building in Excellent Condition
    $199,000
    1,288 SF

    Commercial Building in Excellent Condition

    Well-maintained commercial building with recent upgrades and versatile floor plan.

    2002 Robinson Avenue, Portsmouth, OH 45662
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    Portsmouth Mixed-Use Commercial Property
    $499,000
    1,432 SF

    Portsmouth Mixed-Use Commercial Property

    Commercial property with office space and apartments in Portsmouth, OH.

    2629 Scioto Trail, Portsmouth, OH 45662
    View details
    Furnished Office Space Available
    Contact for pricing
    0.11 Acres

    Furnished Office Space Available

    Furnished office space with utilities and amenities included.

    613 Chillicothe Street, Portsmouth, OH 45662
    View details
    Based on your search, we've compiled 96 Potential Opportunities for your consideration. Besides 5 Active listings in Portsmouth, OH, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 83 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Wheelersburg Commercial Building For Sale
    $749,000
    2,400 SF

    Wheelersburg Commercial Building For Sale

    High-visibility commercial building in Wheelersburg, suitable for various business types.

    8806 Ohio River Road, Wheelersburg, OH 45694
    View details
    Corner Location in Flatwoods, KY
    $299,900
    5,272 SF

    Corner Location in Flatwoods, KY

    Highly visible corner location with redevelopment potential in Flatwoods.

    1606 Argillite Road, Flatwoods, KY 41139
    View details
    Wheelersburg Commercial Building with Rentals
    $1,300,000
    14,265 SF

    Wheelersburg Commercial Building with Rentals

    Commercial building with offices, apartments, Airbnb, and medical facilities.

    11826 Gallia Pike, Wheelersburg, OH 45694
    View details
    High-Visibility Corner Commercial Property
    $299,900
    5,272 SF

    High-Visibility Corner Commercial Property

    Corner commercial property in Flatwoods with redevelopment potential.

    1606 Argillite Road, Flatwoods, KY 41139
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Building in Boneyfiddle District
    $599,000
    6,515 SF

    Commercial Building in Boneyfiddle District

    Mixed-use commercial building with multiple spaces and garages.

    618 3rd St., Portsmouth, OH 45662
    View details
    Prime Commercial Land Opportunity
    $780,000

    Prime Commercial Land Opportunity

    4.996 acres of commercial land in Wheelersburg, Ohio.

    Ohio River Rd, Wheelersburg, OH 45694
    View details
    Prime Development Land in Jackson
    $1,000,000
    22.00 Acres

    Prime Development Land in Jackson

    22 acres of high-traffic land near Walmart.

    0 Main and Ballard Street, Jackson, OH 45640
    View details
    Prime Development Land in Catlettsburg
    $2,700,000
    90.00 Acres

    Prime Development Land in Catlettsburg

    Expansive acreage with flexible zoning and strategic location.

    Route 538, Catlettsburg, KY 41129
    View details

    Explore Off-Market Properties in Portsmouth, OH

    Consider similar Off-Market properties in Portsmouth, OH. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    1004 24th St

    1004 24th St

    OFFICE BUILDING • 1,924 SF
    Value Estimation by Request
    1004 24th St, Portsmouth, OH 45662-2822
    View details
    1870 Coles Blvd

    1870 Coles Blvd

    MEDICAL CLINIC • 0.53 Acres
    Value Estimation by Request
    1870 Coles Blvd, Portsmouth, OH 45662-6900
    View details
    1430 Chillicothe St

    1430 Chillicothe St

    MEDICAL CLINIC • 0.11 Acres
    Value Estimation by Request
    1430 Chillicothe St, Portsmouth, OH 45662-3444
    View details
    1013 Coles Blvd

    1013 Coles Blvd

    MEDICAL CLINIC • 0.10 Acres
    Value Estimation by Request
    1013 Coles Blvd, Portsmouth, OH 45662-2204
    View details
    802 Chillicothe St

    802 Chillicothe St

    OFFICE BUILDING • 0.07 Acres
    Value Estimation by Request
    802 Chillicothe St, Portsmouth, OH 45662-4028
    View details
    2114 Robinson Ave

    2114 Robinson Ave

    OFFICE BUILDING • 0.41 Acres
    Value Estimation by Request
    2114 Robinson Ave, Portsmouth, OH 45662-3743
    View details
    612 Chillicothe St

    612 Chillicothe St

    OFFICE BUILDING • 0.07 Acres
    Value Estimation by Request
    612 Chillicothe St, Portsmouth, OH 45662-4024
    View details
    1915 Scioto Trl

    1915 Scioto Trl

    MEDICAL CLINIC • 0.30 Acres
    Value Estimation by Request
    1915 Scioto Trl, Portsmouth, OH 45662-2874
    View details
    707 6th St

    707 6th St

    OFFICE BUILDING • 0.10 Acres
    Value Estimation by Request
    707 6th St, Portsmouth, OH 45662-4030
    View details
    1502 5th St

    1502 5th St

    OFFICE BUILDING • 0.13 Acres
    Value Estimation by Request
    1502 5th St, Portsmouth, OH 45662-4478
    View details
    1627 11th St

    1627 11th St

    OFFICE BUILDING • 0.09 Acres
    Value Estimation by Request
    1627 11th St, Portsmouth, OH 45662-4525
    View details
    1620 Grant St

    1620 Grant St

    OFFICE BUILDING • 1,960 SF
    Value Estimation by Request
    1620 Grant St, Portsmouth, OH 45662
    View details
    1616 Grant St

    1616 Grant St

    OFFICE BUILDING • 2,064 SF
    Value Estimation by Request
    1616 Grant St, Portsmouth, OH 45662-3663
    View details
    425 Frnt St

    425 Frnt St

    OFFICE BUILDING (MULTI-STORY) • 0.06 Acres
    Value Estimation by Request
    425 Frnt St, Portsmouth, OH 45662-3822
    View details
    630 6th St

    630 6th St

    OFFICE BUILDING • 0.13 Acres
    Value Estimation by Request
    630 6th St, Portsmouth, OH 45662-3925
    View details
    2808 Scioto Trl

    2808 Scioto Trl

    OFFICE BUILDING • 0.13 Acres
    Value Estimation by Request
    2808 Scioto Trl, Portsmouth, OH 45662-2244
    View details
    633 7th St

    633 7th St

    OFFICE BUILDING • 0.14 Acres
    Value Estimation by Request
    633 7th St, Portsmouth, OH 45662-3926
    View details
    625 3rd St

    625 3rd St

    OFFICE BUILDING • 0.12 Acres
    Value Estimation by Request
    625 3rd St, Portsmouth, OH 45662-3903
    View details
    901 4th St

    901 4th St

    OFFICE BUILDING • 0.11 Acres
    Value Estimation by Request
    901 4th St, Portsmouth, OH 45662-4313
    View details

    Portsmouth, OH Office Properties & Spaces Investment Opportunities Market Analysis

    Explore 88 office properties & spaces for sale in Portsmouth, OH, showcased through 5 active listings on our real estate platform. These investment opportunities span a total of 2,704,201 square feet of properties for sale, with an estimated market value of $19,033,500.

    Sale prices for office spaces in Portsmouth, OH start at $165,000, averaging $271,907, and reaching up to $615,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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