Sign Up Successful!
You now have access to more from Realmo!
    For Sale
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Office
    1
    • Retail
    • Office
    • Residential Income
    • Restaurants
    • Industrial
    • Mixed-Use
    • Hospitality
    • Health Care
    • Sports & Entertainment
    • Land
    • Agricultural
    • Specialty
    Price
    Price range
    $
    $
    Size
    Property size / sq.ft.
    AI Search

    Portsmouth, OH Office Properties & Spaces for Sale

    Notify Me
    List
    Map
    Downtown Portsmouth Commercial Building For Sale
    $525,000
    5,526 SF

    Downtown Portsmouth Commercial Building For Sale

    317 Chillicothe St, Portsmouth, OH 45662

    High-visibility commercial building with development potential in historic downtown Portsmouth.

    • High‑visibility location in the heart of historic downtown.
    • Versatile property with development potential on the wide‑open second floor.
    • Basement with 9‑foot ceilings and over 2,500 sq ft of usable space.
    • Recent upgrades include 16 tons of commercial A/C, new 3‑phase electrical, updated plumbing, and new windows.
    • Large display windows, high ceilings, and an open layout.
    Updated: Jan 6
    View details
    Commercial Building in Portsmouth, OH
    $199,000
    1,288 SF

    Commercial Building in Portsmouth, OH

    2002 Robinson Ave, Portsmouth, OH 45662

    Commercial property suitable for medical or office use in Portsmouth.

    • Excellent condition and versatile floor plan suitable for various uses.
    • Recent major improvements: Roof (2021), AC Unit (2021‑22), and Water Heater (2023).
    • Outstanding location.
    • Quality brick structure.
    • Central Air conditioning.
    Updated: Nov 4, 2025
    View details
    Furnished Office Space Available
    Contact for pricing
    0.11 Acres

    Furnished Office Space Available

    Furnished office space with utilities and amenities included.

    613 Chillicothe St, Portsmouth, OH 45662
    View details
    Based on your search, we've compiled 91 Potential Opportunities for your consideration. Besides 3 Active listings in Portsmouth, OH, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 83 Off-Market properties to explore as potential leads, plus 1 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Wheelersburg Commercial Building For Sale
    $799,000
    2,400 SF

    Wheelersburg Commercial Building For Sale

    High-visibility commercial building in Wheelersburg, suitable for various business types.

    8806 Ohio River Rd, Wheelersburg, OH 45694
    View details
    Wheelersburg Office Building For Sale
    $349,900
    5,084 SF

    Wheelersburg Office Building For Sale

    Two-story brick building near US 52 in Wheelersburg, OH.

    11672 Gallia Pike, Wheelersburg, OH 45694
    View details
    Vanceburg Mixed-Use Commercial Opportunity
    $348,000
    0.40 Acres

    Vanceburg Mixed-Use Commercial Opportunity

    Mixed-use building in downtown Vanceburg with high-visibility and income potential.

    89 Second St, Vanceburg, KY 41179
    View details
    Vanceburg Commercial Building with Income
    $49,500
    0.05 Acres

    Vanceburg Commercial Building with Income

    Versatile commercial building with residential rental income potential.

    171 W Main St, Vanceburg, KY 41179
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Building in Boneyfiddle District
    $649,000
    6,515 SF

    Commercial Building in Boneyfiddle District

    Mixed-use commercial building with retail and garage spaces for sale.

    618 3Rd St, Portsmouth, OH 45662
    View details

    Explore Off-Market Properties in Portsmouth, OH

    Consider similar Off-Market properties in Portsmouth, OH. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    301 Offnere St

    301 Offnere St

    OFFICE BUILDING • 0.13 Acres
    Value Estimation
    $255,000
    301 Offnere St, Portsmouth, OH 45662-4655
    View details
    702 Washington St

    702 Washington St

    OFFICE BUILDING • 0.31 Acres
    Value Estimation
    $255,000
    702 Washington St, Portsmouth, OH 45662-3941
    View details
    1013 Coles Blvd

    1013 Coles Blvd

    MEDICAL CLINIC • 0.10 Acres
    Value Estimation
    $210,000
    1013 Coles Blvd, Portsmouth, OH 45662-2204
    View details
    429 2nd St

    429 2nd St

    OFFICE BUILDING • 0.12 Acres
    Value Estimation
    $250,000
    429 2nd St, Portsmouth, OH 45662-3806
    View details
    425 Frnt St

    425 Frnt St

    OFFICE BUILDING (MULTI-STORY) • 0.06 Acres
    Value Estimation
    $230,000
    425 Frnt St, Portsmouth, OH 45662-3822
    View details
    1010 Coles Blvd

    1010 Coles Blvd

    OFFICE BUILDING • 0.58 Acres
    Value Estimation
    $255,000
    1010 Coles Blvd, Portsmouth, OH 45662-2205
    View details
    621 7th St

    621 7th St

    OFFICE BUILDING • 0.05 Acres
    Value Estimation
    $250,000
    621 7th St, Portsmouth, OH 45662-3926
    View details
    1613 Kinneys Ln

    1613 Kinneys Ln

    MEDICAL CLINIC • 0.08 Acres
    Value Estimation
    $225,000
    1613 Kinneys Ln, Portsmouth, OH 45662-3115
    View details
    1625 Offnere St

    1625 Offnere St

    OFFICE BUILDING • 0.45 Acres
    Value Estimation
    $255,000
    1625 Offnere St, Portsmouth, OH 45662-3537
    View details
    1500 Grant St

    1500 Grant St

    MEDICAL CLINIC • 0.12 Acres
    Value Estimation
    $225,000
    1500 Grant St, Portsmouth, OH 45662-3606
    View details
    1759 State Rte 139

    1759 State Rte 139

    OFFICE BUILDING • 816 SF
    Value Estimation
    $235,000
    1759 State Rte 139, Portsmouth, OH 45662-8858
    View details
    2103 8th St

    2103 8th St

    OFFICE BUILDING • 0.09 Acres
    Value Estimation by Request
    2103 8th St, Portsmouth, OH 45662-4735
    View details
    1735 Waller St

    1735 Waller St

    OFFICE BUILDING • 0.12 Acres
    Value Estimation
    $255,000
    1735 Waller St, Portsmouth, OH 45662-3540
    View details
    1907 11th St

    1907 11th St

    OFFICE BUILDING • 0.76 Acres
    Value Estimation
    $255,000
    1907 11th St, Portsmouth, OH 45662-4531
    View details
    1870 Coles Blvd

    1870 Coles Blvd

    MEDICAL CLINIC • 0.53 Acres
    Value Estimation
    $255,000
    1870 Coles Blvd, Portsmouth, OH 45662-6900
    View details
    2808 Scioto Trl

    2808 Scioto Trl

    OFFICE BUILDING • 0.13 Acres
    Value Estimation
    $180,000
    2808 Scioto Trl, Portsmouth, OH 45662-2244
    View details
    6606 Gallia St

    6606 Gallia St

    OFFICE BUILDING • 512 SF
    Value Estimation
    $300,000
    6606 Gallia St, Portsmouth, OH 45662-5646
    View details
    35 Bierly Rd

    35 Bierly Rd

    OFFICE BUILDING • 0.96 Acres
    Value Estimation
    $275,000
    35 Bierly Rd, Portsmouth, OH 45662-8502
    View details
    1616 Grant St

    1616 Grant St

    OFFICE BUILDING • 2,064 SF
    Value Estimation
    $200,000
    1616 Grant St, Portsmouth, OH 45662-3663
    View details
    1817 Oakland Ave

    1817 Oakland Ave

    MEDICAL CLINIC
    Value Estimation by Request
    1817 Oakland Ave, Portsmouth, OH 45662
    View details
    1725 27th St

    1725 27th St

    MEDICAL CLINIC
    Value Estimation by Request
    1725 27th St, Portsmouth, OH 45662
    View details

    Portsmouth, OH Office Properties & Spaces Investment Opportunities Market Analysis

    Explore 86 office properties & spaces for sale in Portsmouth, OH, showcased through 3 active listings on our real estate platform. These investment opportunities span a total of 2,651,498 square feet of properties for sale, with an estimated market value of $18,270,000.

    Prices for office spaces in Portsmouth, OH start at $165,000, averaging $268,676, and reaching up to $615,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you have the most current data.

    List
    Map

    Browse Office Properties & Spaces for Sale Near Portsmouth, OH

    Popular Searches in Portsmouth, OH

    Most Searched ZIP Codes in Portsmouth, OH

    • 45662

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Create New Password
    • At least 8 characters
    • Contains both letters and numbers
    • Contains uppercase and lowercase letters
    • At most 32 characters
    • Password required
    • Password reset link has expired. Please request a new one.