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Desoto, TX Office Spaces for Lease

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15 properties
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Freestanding Medical Office Building
Updated: Jul 26
Freestanding Medical Office Building

216 Dalton Dr, Desoto, TX 75115

$17 SF/Yr
1,788 sqft 0.50 AC lot
1,788 SF freestanding building on ±0.50 acres
O‑1 (Neighborhood Office) zoning
Multiple treatment or office rooms with plumbing pre‑run
Approximately 40‑foot covered front entry
Two HVAC units and extensive cable and internet infrastructure
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Retail and Office Marketplace Space
Updated: Jul 2
Retail and Office Marketplace Space

320-360 E Belt Line Rd, Desoto, TX 75115

Contact for pricing
1,600 sqft
26,000‑square‑foot marketplace space in DeSoto, TX
Former ACE Hardware building repurposed into a mix of restaurants, retail spaces, and offices
Space within an existing commercial marketplace concept serving small business owners
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Office Space in Grow DeSoto Marketplace
Office Space in Grow DeSoto Marketplace

320-360 E Belt Line Rd, Desoto, TX 75115

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2,000 sqft

Repurposed marketplace with office space alongside restaurants and retail uses in DeSoto.

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Office Suite with Reception Area
Office Suite with Reception Area

1801 N Hampton Rd, Desoto, TX 75115

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1,772 sqft

Office suite includes reception area, multiple offices, an open area, and closets for practical workflow and storage.

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Mixed-Use Market Center
Mixed-Use Market Center

320-360 E Belt Line Rd, Desoto, TX 75115

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481 sqft

Former ACE Hardware anchor space now supports restaurants, retail, and small office tenants at Grow DeSoto Market Place.

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Interior Office Suite
Interior Office Suite

1801 N Hampton Rd, Desoto, TX 75115

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246 sqft

Interior office suite with a reception area and a dedicated entrance.

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Desoto Office Space For Rent
Desoto Office Space For Rent

911 N HAMPTON ROAD, Desoto, TX 75115

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18,643 sqft

Office suites available for lease in Desoto, Texas.

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Office Suite with Private Offices
Office Suite with Private Offices

1601 Osprey Dr, Desoto, TX 75115

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1,680 sqft

Office suite includes a reception area, a private office, and an RR.

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Office Unit with Private Offices
Office Unit with Private Offices

1229 E Pleasant Run Rd, Desoto, TX 75115

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623 sqft

Reception area and two private offices support a compact professional layout.

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Office Space with Corner Location
Office Space with Corner Location

1801 N Hampton Rd, Desoto, TX 75115

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1,060 sqft 1.57 AC lot

Office unit featuring reception area, window offices, and corner location.

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DeSoto Office Space For Rent
DeSoto Office Space For Rent

1229 E Pleasant Run Rd, Desoto, TX

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373 sqft 2.54 AC lot

Office space available for lease in DeSoto, Texas.

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Versatile Commercial Spaces For Rent
Versatile Commercial Spaces For Rent

1615 N Hampton Rd, Desoto, TX

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868 sqft 3.58 AC lot

Commercial spaces suitable for office, retail, restaurant, and personal service.

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DeSoto Retail and Office Space
DeSoto Retail and Office Space

320-360 E Belt Line Rd, Desoto, TX

Contact for pricing
430 sqft 5.84 AC lot

26,000 SF marketplace with retail, restaurant, and office spaces.

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DeSoto Office Space Available
DeSoto Office Space Available

1510 N Hampton Rd, Desoto, TX

Contact for pricing
2,359 sqft 2.50 AC lot

Office space available for rent in DeSoto, Texas.

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DeSoto Office Building For Rent
DeSoto Office Building For Rent

1801 N Hampton Rd, Desoto, TX 75115

Contact for pricing
68,000 sqft

68,000+ sq ft office building with on-site amenities.

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Based on your search, we've compiled 30 Potential Opportunities for your consideration. Besides 15 Active listings in Desoto, TX, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 11 Properties for Sales.

Office Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Brand-New Flex Space with Office
Brand-New Flex Space with Office

3350 Balomede Street, Lancaster, TX 75134

$3,000/Mo

Under-construction flex warehouse and office development completing April 2026 with flexible mixed-use zoning approval.

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Medical Office Building with Backup Generator
Medical Office Building with Backup Generator

7989 WEST VIRGINIA DR, Dallas, TX 75237

Contact for pricing
17,000 sqft

Two-story medical facility offers a built-out surgery center on the first floor and flexible medical office space above.

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Lancaster Office Building For Sale
Lancaster Office Building For Sale

3136 Danieldale Rd, Lancaster, TX

Contact for pricing
3,900 sqft 1.64 AC lot

3,900 SF office building on 1.52 acres.

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Office Space Available For Lease
Office Space Available For Lease

7999 W Virginia Dr, Dallas, TX 75237

Contact for pricing

Office space for lease at 7999 W Virginia Dr, Dallas.

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Similar Spaces for Sale in Desoto, TX

Consider Similar Space for Sale. We found 11 Spaces matching your search parameters.

Multi-Suite Office Building
Multi-Suite Office Building

1701 N Hampton Rd, Desoto, TX 75115

$1,500,000
13,565 sqft

Configured with private offices, multi-desk work areas, conference rooms, and staff support spaces.

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Office Building with Expansion Land
Office Building with Expansion Land

718 N Hampton Rd, Desoto, TX 75115

$1,500,000
1,960 sqft 2.00 AC lot

Existing office configuration includes multiple rooms and a full kitchen on a spacious commercial parcel.

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General Retail Mixed-Use Property
General Retail Mixed-Use Property

121 Little John Drive, Desoto, TX 75115

$434,900
3.34 AC lot

Three-bedroom residence with attached studio apartment and commercial zoning supports a live-work configuration.

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Office Building on Acreage
Office Building on Acreage

718 N Hampton Road, Desoto, TX 75115

$1,500,000
2.00 AC lot

Brick construction, a full kitchen, multiple rooms, and open, lot, and garage parking support varied commercial configurations.

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Office Building with 5 Suites
Office Building with 5 Suites

1701 N Hampton Road, Desoto, TX 75115

$1,500,000
1.03 AC lot

Brick office property with multiple workspaces, conference rooms, and covered as well as lot parking.

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General Retail Mixed-Use Property
General Retail Mixed-Use Property

Desoto, TX 75115

$434,900
3.12 AC lot

Residential and studio components support a live-work configuration on a general retail-zoned site.

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Flex Space with Grade-Level Doors
Flex Space with Grade-Level Doors

1101 S Hampton Rd, Desoto, TX 75115

Contact for pricing
22,500 sqft

Flexible commercial space combines private offices, heavy power, and abundant off-street parking.

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DeSoto Flex Space Investment Opportunity
DeSoto Flex Space Investment Opportunity

400 E Centre Park Blvd Ste 101, Desoto, TX 75115

$3,295,000
1.53 AC lot

100% occupied flex space near I-35, ideal for investors.

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Occupied Flex Space with NNN Leases
Occupied Flex Space with NNN Leases

400 E Centre Park Boulevard # 101, Desoto, TX 75115

$3,295,000

Warehouse and office configuration with established occupancy and access to major regional transportation routes.

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Desoto, TX Office Spaces Lease Rates & Market Statistics

Explore 15 Office Spaces for lease in Desoto, TX on Realmo, a commercial real estate exchange covering the Desoto area. The current inventory totals 101,923 square feet of properties — an average of ~6,800 SF per listing.

Asking lease rates for Office Spaces in Desoto start at $17 SF/Yr, average $17 SF/Yr, and reach $17 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $17 SF/Yr is 29% below the Texas state average of $24.09 SF/Yr.

Desoto accounts for 1% of the 1,484 office spaces currently available across Dallas County, where nearby markets include Dallas and Irving.

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