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Murrells Inlet, SC Office Spaces for Lease

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Found 39 office space listings for lease in Murrells Inlet, SC, averaging $28/SF/YR. Use lease type data to compare options faster.
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14-Office Professional Building
Updated: Nov 11
14-Office Professional Building

11923 Plaza Dr., Murrells Inlet, SC 29576

$6,795/Mo
4,292 sqft 0.38 AC lot
14 private offices, with seven on each floor
4,292 square feet across two stories
Renovated in 2024; all‑brick exterior
Reception area, conference room, kitchen/break room, and four restrooms
Located in an office park along the Highway 17 Bypass
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Professional Office Suite
Updated: Nov 6
Professional Office Suite

3959 Highway 17 Bypass, Murrells Inlet, SC 29576

$3,150/Mo
2,000 sqft 0.60 AC lot
2,000 square feet of ground‑level office space
Six private offices and a central open work area
Separate rear room with sink, plus storage and one restroom
GC zoning; professional or medical office use is noted
Front and rear parking, landscaped courtyard, and highway signage opportunity
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Renovated Medical Office Suite
Renovated Medical Office Suite

4310 Highway 17 Business, Murrells Inlet, SC 29576

$8,000/Mo
3,557 sqft  3 acres
Highway access

Recently renovated Class A space with shared patient amenities, dedicated elevators, and services included in the lease package.

Shared lobby with complimentary coffee and beverage station  Monument signage  Sentry 30 Security System  Automatic water shut-off system
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Freestanding Office Building
Freestanding Office Building

9250 Highway 17 Bypass #Building B, Murrells Inlet, SC 29576

$8,432/Mo
14–24 people  3,667 sqft  Renovated 2019  1-story
1 meeting room

The single-story floor plan has private offices and a glass-walled conference room, with central heat and air.

Central heat and air  Public water and sewer  On-site parking
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Second-Floor Office Unit
Second-Floor Office Unit

870 Inlet Square Dr., Murrells Inlet, SC 29576

$1,450/Mo
4–8 people  1,246 sqft  0.59 acres  Floor 2
Highway access

HC-zoned office space positioned near major commercial and recreational destinations in Murrells Inlet.

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New Mixed-Use Space
New Mixed-Use Space

5100 Highway 17 Bypass, Murrells Inlet, SC 29576

$3,125/Mo
Multi-tenant  2,500 sqft  12,000 sqft building  1.9 acres
Highway access  Road access

New construction supports flexible medical, professional office, and specialty retail configurations with direct exposure on the Highway 17 Bypass.

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Executive Office Suite
Executive Office Suite

3955 Highway 17 Bypass, Murrells Inlet, SC 29576

$525/Mo
1 person  81 sqft
Highway access

Compact workspace with shared conference and break facilities; water, sewer, and electric are included.

Shared conference room  Break area
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Renovated Medical Office Suite
Renovated Medical Office Suite

4310 Highway 17 Business #Unit 103, Murrells Inlet, SC 29576

$8,000/Mo
3,557 sqft
Highway access

GC-zoned space includes utilities, trash, and janitorial service in the rent.

Utilities to site  Shared lobby  Complimentary coffee bar and beverage station  Monument signage opportunities
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Office Suite with Conference Room
Office Suite with Conference Room

5187 Horry Dr., Murrells Inlet, SC 29576

$1,833/Mo
4–6 people  1,000 sqft  0.5 acres
Highway access

The 1,000-square-foot space includes a reception area, executive offices, and dedicated break room areas.

On-site parking  Monument signage  Reception area  Break room
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New Flex Space with Roll-Up Doors
New Flex Space with Roll-Up Doors

4960 Highway 17, Murrells Inlet, SC 29576

$3,000/Mo
1,625 sqft  brick, Hardie plank siding, metal accents  4 buildings  Multi-tenant
Highway access  Road access

New multi-building commercial development offering adaptable office, showroom, warehouse, and service configurations.

Ample on-site parking  Excellent ingress/egress and circulation  Roll-up doors  Signage opportunities
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New Medical Office Suites
New Medical Office Suites

5100 Highway 17, Murrells Inlet, SC 29576

$3,125/Mo
Multi-tenant  2,500 sqft  12,000 sqft building  Built 2027
Highway access  Road access

New construction with adaptable suite layouts, on-site parking, and direct exposure along a heavily traveled commercial corridor.

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Executive Office Suite
Executive Office Suite

3955 Highway 17 Bypass #Unit C, Murrells Inlet, SC 29576

$525/Mo
1 person  81 sqft
Highway access + Road access

A shared conference room and break area support day-to-day business operations.

2 parking spaces  Shared conference room  Break area
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Medical Office Suite with Treatment Rooms
Medical Office Suite with Treatment Rooms

4764 Frontage Rd. #Unit C, Murrells Inlet, SC 29576

$1,500/Mo
725 sqft

Furnishings, fixtures, and treatment equipment support health and beauty services in this leased space.

4 parking spaces  Furnished  Beds  Towel warmers
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Office Suite with Three Private Offices
Office Suite with Three Private Offices

11945 Grandhaven Dr. #Suite D, Murrells Inlet, SC 29576

$1,875/Mo
3–6 people  900 sqft  Built 2008
3 private offices  Highway access

A reception area, two restrooms, and a kitchenette complement the private-office layout.

96 parking spaces
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Office Unit with Storage
Office Unit with Storage

5187 Horry Dr. #Unit A, Murrells Inlet, SC 29576

$3,670/Mo
8–13 people  2,000 sqft
1 meeting room  Highway access

GC-zoned office space includes a reception area, conference room, executive offices, and dedicated break room.

Monument signage  On-site parking  Break room areas
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Office Suite with Monument Signage
Office Suite with Monument Signage

5187 Horry Dr. #Unit B, Murrells Inlet, SC 29576

$1,833/Mo
4–6 people  1,000 sqft
1 meeting room  Highway access

The professional layout includes a reception area, conference room, executive offices and a dedicated break room.

Monument signage
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Renovated Office Units
Renovated Office Units

9250 Highway 17 Byp, Murrells Inlet, SC 29576

$8,431/Mo
Renovated 2019

Single-story space includes private offices, a glass conference room, and on-site parking for staff and clients.

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Executive Office Unit
Executive Office Unit

3955 Highway 17 Bypass #Unit B, Murrells Inlet, SC 29576

$525/Mo
1 person  81 sqft
1 meeting room  Highway access + Road access

The lease includes access to shared meeting and break areas, with utilities covered.

2 parking spaces  Break area
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Medical Office with Conference Room
Medical Office with Conference Room

955 Riverwood Dr., Murrells Inlet, SC 29576

$4,800/Mo
3,200 sqft  Built 1988

The existing office layout includes private work areas and a kitchenette for day-to-day operations.

Kitchenette
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Second-Floor Office Suite
Second-Floor Office Suite

641 Little Tony Ave. #2nd Floor, Suite 3, Murrells Inlet, SC 29576

$650/Mo
1 person  150 sqft  Built 2004  Floor 2
Highway access

A compact workspace includes shared access to a restroom and kitchenette in a professional office building.

12 parking spaces  Common restroom  Common kitchenette
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Second-Floor Office Suite
Second-Floor Office Suite

641 Little Tony Ave. #2nd Floor, Suite 1, Murrells Inlet, SC 29576

$650/Mo
1 person  195 sqft  Built 2004  Floor 2
Highway access

Shared restroom and kitchenette serve this professional office space in Murrells Inlet.

12 parking spaces  Common restroom  Kitchenette
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Office Suite with Private Office
Office Suite with Private Office

3940 Highway 17 South, Murrells Inlet, SC 29576

$1,650/Mo
3–6 people  900 sqft  Built 1994
1 private office  Highway access

GC-zoned space features broad windows that bring natural light into the office.

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Office Suite with Reception Area
Office Suite with Reception Area

675-D Wachesaw Rd., Murrells Inlet, SC 29576

$2,000/Mo
5–9 people  1,350 sqft
4 private offices  Highway access

The layout includes four offices and two restrooms.

View details
Office Suite with Conference Room
Office Suite with Conference Room

9898 Merry Ln., Murrells Inlet, SC 29576

$2,400/Mo
6–11 people  1,700 sqft  Built 2008
4 private offices  1 meeting room

The layout includes a reception area, four private offices, a conference room, and two bathrooms.

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Murrells Inlet, SC Office Spaces Lease Rates & Market Statistics

Browse 39 Office Spaces for lease in Murrells Inlet, SC on Realmo, a commercial real estate marketplace serving the Murrells Inlet area. The current inventory totals 65,241 square feet of properties — an average of ~1,650 SF per listing.

Asking lease rates for Office Spaces in Murrells Inlet start at $11.32 SF/Yr, average $27.84 SF/Yr, and reach $77.78 SF/Yr at the top of the market. That's a 7x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $27.84 SF/Yr is 11% above the South Carolina state average of $25.15 SF/Yr.

Murrells Inlet accounts for 16% of the 248 office spaces currently available across Horry County, where nearby markets include Myrtle Beach and North Myrtle Beach. By space type, the market includes 30 office units, 9 medical office space listings and 3 office buildings — office buildings typically offer the lowest entry point, while office units command the highest rates.

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