Madison County, OH Office Spaces for Rent & Lease

Updated: Nov 22, 2025

West Jefferson Medical/Office Space

487 West Main Street, West Jefferson, OH 43162

$10 SF/Yr

2,250 sqft

Convenient location directly off Main St and National Pk 90/Broad St in West Jefferson.
Single‑story building suitable for general or medical office.
2,200 SF Suite E available.
Former Pharmacy Space.
Generous parking available.

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Updated: Oct 10, 2025

Updated Downtown Storefront Space

84 E Main St, West Jefferson, OH 43162

$3,200/Mo

2,535 sqft

Fully updated commercial storefront for lease at 82 E Main Street in West Jefferson
Approximately 2,535 SF of versatile space for retail, professional office, service‑based businesses, and other commercial uses
Includes a reception/lobby area and conference room furnishings
Existing kitchenette appliances included
Free on‑site parking available

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Historic Office Space in Plain City

125 W Main St, Plain City, OH 43064

Contact for pricing

2,677 sqft

Restored office space in a historic Plain City building.

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Based on your search, we've compiled 13 Potential Opportunities for your consideration. Besides 3 Active listings in Madison County, OH, we suggest exploring alternatives. Similar 6 Properties for Sales.

Similar Spaces for Sale in Madison County, OH

Consider Similar Space for Sale. We found 6 Spaces matching your search parameters.

Flexible Corner Lot Commercial Building

13790 Main Street, Sedalia, OH 43151

$170,000

4,732 sqft

Versatile 4,000+ SF building with recent HVAC upgrades and an open interior layout for office, studio, retail, or services.

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Office Building with Conversion Potential

16 North Main Street, London, OH 43140

$300,000

5,684 sqft

Currently operating as an office, with interior reconfiguration toward residential use underway by prior ownership.

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Versatile Building with Large Lot

249 W High St, London, OH 43140

Contact for pricing

6,524 sqft

6,524 SF building with multi-use potential and additional parking.

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Office Building with 13,784 SF

170 W. Pearl St, West Jefferson, OH 43162

Contact for pricing

13,784 sqft

Office building offered for sale with 13,784 SF of total space.

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NNN Office Investment Building

371 Lafayette St, London, OH 43140

Contact for pricing

Office building leased long term to Madison Health under an NNN structure.

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Leased Postal Office Building

219 Maple St, Plain City, OH 43064

$179,900

Office building leased to the U.S. Postal Service, offering an established tenant situation for investors or owner-operators.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Prime Lexington Outlot Opportunity

3330 Partner Place, Lexington, KY 40503

Contact for pricing

Outlot for ground lease or build-to-suit in South Lexington.

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Commercial Land Parcel with Utilities

2585 Maple Lane, Pittsburgh, PA 15241

$50,000/Mo

Level, fully serviced commercial parcel with approvals in place and signage permitted up to 20 sq ft.

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Novi Corporate Campus Land Opportunity

12 Mile Road, Novi, MI 48374

Contact for pricing

6 sqft

6.60 acre site approved for high-tech R&D/office building.

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Prime Commercial Land For Lease

220 Silver Lake Road, Church Hill, TN 37642

$285,000/Mo

3 acres of B-3 zoned land with city amenities.

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Madison County, OH Office Spaces Market Trends and Statistics

Explore Office Spaces leasing options in Madison County, OH with 3 listings featured on our commercial real estate exchange. The current inventory includes 4,785 square feet of properties with an estimated lease value of $25.15 SF/Yr.

Estimated lease rates for Office Spaces in Madison County, OH begin at $10 SF/Yr, with an average of $12.57 SF/Yr and extend to $15.15 SF/Yr.