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St Lucie County, FL Office Spaces for Lease

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113 properties
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Shared Medical Co-working Space
Shared Medical Co-working Space

320-300 Nw Bethany Dr, Port St Lucie, FL 34986

$3,000/Mo per office

Flexible, turnkey medical workspace in St. Lucie West.

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Fort Pierce Retail/Office/Medical Plaza
Fort Pierce Retail/Office/Medical Plaza

800 Virginia Avenue, Fort Pierce, FL 34982

$12 SF/Yr
52,746 sqft

Neighborhood plaza with spaces for retail, office, and medical tenants.

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Retail/Office Space on US Highway
Retail/Office Space on US Highway

Port St Lucie, FL 34952

$12 SF/Yr
19,008 sqft

Retail, office, or medical spaces with high visibility.

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Retail/Office Suite with Private Office
Retail/Office Suite with Private Office

104-270 Nw Peacock Boulevard, St Lucie West, FL 34986

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1,300 sqft

Suite 104 offers an open floor plan, one private office, and a restroom in a CG-zoned commercial location.

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Professional Office Suite
Professional Office Suite

7430-7448 S Federal Hwy, Port Saint Lucie, FL 34952

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1,000 sqft

Three private offices, a kitchenette, and restroom support a functional professional-services layout.

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Office/Warehouse Flex Space
Office/Warehouse Flex Space

2190 NW Reserve Park Trace, Port Saint Lucie, FL 34986

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1,440 sqft

The unit combines office and warehouse areas for contractors, storage, light industrial, and service-related operations.

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Office Suite for Lease
Office Suite for Lease

2215 Nebraska Avenue 3e, Fort Pierce, FL 34950

$2,775/Mo

Office suite available for lease at 2215 Nebraska Avenue, with parking lot access off S 25th Street.

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Freestanding Historic Office Building
Freestanding Historic Office Building

408 N 6th St, Fort Pierce, FL 34950

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1,200 sqft

Well-maintained office with a waiting room, four private offices, break room, and ADA-compliant restroom.

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Professional Office Building with Parking
Professional Office Building with Parking

4609 North US Highway 1, Fort Pierce, FL 34946

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1,144 sqft 1.04 AC lot

Turnkey office building with six private offices and large on-site parking on high-visibility US Highway 1.

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Light Industrial Flex Space
Light Industrial Flex Space

913 Edwards Rd, Fort Pierce, FL 34982

$12.50 SF/Yr

Office and open warehouse areas provide a practical blend of administrative and industrial workspace.

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Retail and Medical Office Outparcel
Retail and Medical Office Outparcel

4150 Okeechobee Rd, Fort Pierce, FL 34947

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1,124 sqft

Prominent outparcel with mature landscaping and abundant on-site parking along Okeechobee Road.

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Retail-Ready Office Suite
Retail-Ready Office Suite

Port St Lucie, FL 34986

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1,300 sqft

Versatile suite with an open layout, one private office, and one restroom in a high-traffic commercial plaza.

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Retail Space in Anchored Plaza
Retail Space in Anchored Plaza

6642 S Us Hwy 1, Port St. Lucie, Port St Lucie, FL 34952

$2,275/Mo

Lease opportunity surrounded by six established restaurants and anchored by Dollar Tree and Card House.

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Medical Office Building
Medical Office Building

2624 South US Highway 1, Fort Pierce, FL 34982

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2,320 sqft

Medical office space available on US Highway 1 for lease, offering a dedicated setting for healthcare practices.

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Quincy Professional Plaza
Quincy Professional Plaza

1803 S 25Th St, Unit Suite 5, Fort Pierce, FL 34947

$2,200/Mo
1,440 sqft

medical, dentist, insurance, retail

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Executive Office Suite For Rent
Executive Office Suite For Rent

Port St Lucie, FL 34952

$1,527/Mo
833 sqft 0.02 AC lot

Executive office suite in Port St. Lucie medical corridor.

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Medical Office Condo with Exam Rooms
Medical Office Condo with Exam Rooms

1801 S 23rd Street 3, Fort Pierce, FL 34950

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1,734 sqft

Move-in-ready medical office condo with four exam rooms, offices, and dedicated lab or prep space.

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Turnkey Medical Office Suite
Turnkey Medical Office Suite

150 SW Chamber Court, Port St Lucie, FL 34986

Contact for pricing
1,911 sqft

Fully renovated office suite includes exam rooms, offices, restrooms, and a staff breakroom with a separate rear entrance.

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Endcap Professional Office Suite
Endcap Professional Office Suite

Port St Lucie, FL 34986

$25 SF/Yr

Endcap office suite with reception, conference room, five private offices, open workspace, and kitchenette.

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Port St. Lucie Warehouse Space
Port St. Lucie Warehouse Space

Port St Lucie, FL 34984

$1,800/Mo

Warehouse space available for rent in Port St. Lucie.

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First-Floor Medical Office Suite
First-Floor Medical Office Suite

Port St Lucie, FL 34952

Contact for pricing
1,530 sqft

A 1,530 SF first-floor suite with reception, four exam rooms with sinks, and two restrooms in Hillmoor Professional Plaza.

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Medical Office Space Available 2025
Medical Office Space Available 2025

Port St Lucie, FL 34952

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1,530 sqft

Medical office space near St. Lucie Medical Center available 2025.

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Built-Out Office Suite
Built-Out Office Suite

130-171 S Indian River Dr, Fort Pierce, FL 34950

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1,085 sqft

Central Commercial zoning and an established layout accommodate professional office use with private and collaborative areas.

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Professional Office Space Available
Professional Office Space Available

Port St Lucie, FL 34952

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940 sqft

Class A office space in professional center for lease.

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