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    Palmetto, FL Office Spaces for Lease

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    Bradenton, FL Sarasota, FL Holmes Beach, FL
    8 properties
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    Modern Office Suite on US-41
    Updated: May 3
    Modern Office Suite on US-41

    10305 US HIGHWAY 41 N, Palmetto, FL 34221

    $4,000/Mo
    11,345 sqft · $4 SF/Yr
    Prime location on S Tamiami Trail (US‑41) with high visibility and easy access.
    Turnkey, modern 1,206 sq. ft. office suite ready for immediate occupancy.
    Three large private offices, spacious reception area, private bathroom, and dedicated kitchen.
    Strategically located 1.5 miles north of I‑275, providing easy access to St. Petersburg, Tampa, and Sarasota.
    High‑standard finishes including luxury vinyl flooring, modern lighting, and large windows with privacy treatments.
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    Stand Alone Building For Lease
    Updated: Oct 28, 2025
    Stand Alone Building For Lease

    1331 10th St E, Palmetto, FL

    $18 SF/Yr
    2,640 sqft · $3,960/Mo
    Stand‑alone building: Only stand‑alone building in River North Business Center.
    Flexible zoning: CG zoning designation suitable for office, medical, or retail use.
    Ample parking: Abundance of parking spaces available for customers and employees.
    Functional floorplan: Includes 10 private offices, reception area, open area, kitchenette, and 2 handicap restrooms.
    Strategic location: Located between US 41/Business 41 and I‑75, with easy access to I‑275.
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    High-Visibility Office/Retail Lease
    High-Visibility Office/Retail Lease

    701 8th Ave W, Palmetto, FL 34221

    $20 SF/Yr

    Street-front space in Palmetto designed for businesses seeking prominent exposure on a major downtown road.

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    Retail/Office Unit on 8th Avenue
    Retail/Office Unit on 8th Avenue

    835 8TH Ave W, Palmetto, FL 34221

    $10,800/Mo

    Highly visible retail/office unit with front and rear access.

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    Palmetto Retail/Flex Space Available
    Palmetto Retail/Flex Space Available

    925 10th St E, Palmetto, FL 34221

    $19 SF/Yr
    2,240 sqft · $3,546/Mo

    Versatile 2,240 SF retail/flex space in Palmetto, Florida.

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    Downtown Palmetto Commercial Property
    Downtown Palmetto Commercial Property

    435 10th Ave W, Palmetto, FL

    Contact for pricing
    4,600 sqft

    Two-story commercial property with retail and office space.

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    Office Suite on 49th Street
    Office Suite on 49th Street

    818 49th Street East, Palmetto, FL 34221

    Contact for pricing
    450 sqft

    450 SF office suite with frontage on 49th Street.

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    Renovated Building on US41/US19 Interchange
    Renovated Building on US41/US19 Interchange

    3966 U.S. 41, Palmetto, FL

    Contact for pricing

    Modernized freestanding building suitable for retail, restaurant, or offices.

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    Based on your search, we've compiled 23 Potential Opportunities for your consideration. Besides 8 Active listings in Palmetto, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 7 Properties for Sales.

    Office Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Stand-Alone Medical Office Building
    Stand-Alone Medical Office Building

    410 4th Ave E, Bradenton, FL 34208

    $735,000 SF/Yr
    2,108 sqft · $129,115,000/Mo

    Stand-alone medical/office building with check-in reception, private and open areas, and nine designated parking spaces.

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    Downtown Bradenton Office Space
    Downtown Bradenton Office Space

    1111 3rd Avenue W., Bradenton, FL 34205

    $16 SF/Yr

    Historic building in downtown Bradenton with flexible office options.

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    Class A Riverfront Office Space
    Class A Riverfront Office Space

    101 Riverfront Blvd, Bradenton, FL

    $14 SF/Yr
    5,871 sqft · $6,971/Mo

    Premier office space with Manatee River views and convenient access.

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    Professional Office Building in Riverwalk
    Professional Office Building in Riverwalk

    100 3rd Avenue W., Bradenton, FL 34205

    $26 SF/Yr

    Well-maintained office building near Manatee Memorial Hospital and downtown Bradenton.

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    Similar Spaces for Sale in Palmetto, FL

    Consider Similar Space for Sale. We found 7 Spaces matching your search parameters.

    Mixed-Use Land with Existing Home
    Mixed-Use Land with Existing Home

    2519 MOCCASIN WALLOW ROAD, Palmetto, FL 34221

    $1,199,999
    1,080 sqft · 1.96 AC lot

    High-visibility parcel with substantial road frontage and an on-site residence that can support owner-use or adaptive plans.

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    High-Frontage Land Parcel
    High-Frontage Land Parcel

    2519 MOCCASIN WALLOW ROAD, Palmetto, FL 34221

    $1,199,999
    1.96 AC lot

    Nearly 2-acre A-1 parcel with substantial road frontage and an existing residential structure on-site.

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    Palmetto Medical Building on 2.24 Acres
    Palmetto Medical Building on 2.24 Acres

    602 4th Avenue West, Palmetto, FL 34221

    $2,495,000
    16,382 sqft · 2.24 AC lot

    Strategically located medical building with flexible space and expansion potential.

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    High-Visibility Land on Moccasin Wallow
    High-Visibility Land on Moccasin Wallow

    2519 MOCCASIN WALLOW ROAD, Palmetto, FL 34221

    $1,199,999
    1,080 sqft · 2.49 AC lot

    2.5 acre parcel with road frontage in rapidly growing area.

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    Palmetto Tower with Redevelopment Potential
    Palmetto Tower with Redevelopment Potential

    600 W 8TH AVE, Palmetto, FL

    $6,000,000
    63,188 sqft · 3.23 AC lot

    Multi-story office building with vacant lots in downtown Palmetto.

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    Palmetto Mixed-Use Development Opportunity
    Palmetto Mixed-Use Development Opportunity

    834 RIVERSIDE DRIVE, Palmetto, FL 34221

    $3,500,000
    3.40 AC lot

    Development site near Manatee River suitable for mixed-use projects.

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    Palmetto 52-Acre Assemblage Opportunity
    Palmetto 52-Acre Assemblage Opportunity

    1321 77th St E, Palmetto, FL 34221

    $10,500,000
    16,443 sqft · 52.00 AC lot

    52 acres with buildings, prime location, development potential.

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land Near Shopping
    Commercial Land Near Shopping

    6012 LORRAINE ROAD, Bradenton, FL 34211

    $21,000 SF/Yr
    200,000 sqft · $350,000,000/Mo

    Commercial land for rent, conveniently located near shopping.

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    Lakeland Commercial Business Park Spaces
    Lakeland Commercial Business Park Spaces

    2525 Drane Field Road, Lakeland, FL 33811

    $17 SF/Yr

    Commercial spaces for lease in West Lakeland business park.

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    WINTER PARK Land Lease Opportunity
    WINTER PARK Land Lease Opportunity

    5589 LAKE HOWELL ROAD, Winter Park, FL 32792

    $8,500/Mo
    23,056 sqft · $4 SF/Yr

    Commercial land lease opportunity in Winter Park, Florida.

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    Melbourne Land for Ground Lease
    Melbourne Land for Ground Lease

    6365 N. Wickham Road, Melbourne, FL 32940

    $36 SF/Yr

    1.2-acre development site in Viera/Suntree area available for lease.

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    Palmetto, FL Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in Palmetto, FL with 8 listings featured on our commercial real estate exchange. The current inventory includes 13,985 square feet of properties with an estimated lease value of $22 SF/Yr.

    Estimated lease rates for Office Spaces in Palmetto, FL begin at $4 SF/Yr, with an average of $11 SF/Yr and extend to $18 SF/Yr.
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