Palmetto, FL Office Spaces for Rent & Lease

Updated: May 3

Modern Office Suite with Private Offices

10305 US HIGHWAY 41 N, Palmetto, FL 34221

$4,000/Mo

11,345 sqft 8.64 AC lot

Three private offices plus a reception area
Private bathroom and dedicated kitchen
1,206 sq. ft. office suite with luxury vinyl flooring and modern lighting
Located 1.5 miles north of I‑275 along US‑41
On‑site parking for over 20 cars

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Updated: Jun 2

Office/Medical End Suite

1301 10th St E, Palmetto, FL 34221

$22 SF/Yr

850 sqft

850 SF professional office/medical suite in River North Business Center (Year built 1981)
End unit with abundant natural light from N, W & S exposure
Layout includes 2 private offices plus reception/lobby and open bullpen
Updated vinyl plank flooring throughout
Located on US 301 with ample on‑site parking

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High-Visibility Office/Retail Lease

701 8th Ave W, Palmetto, FL 34221

$20 SF/Yr

Street-front space in Palmetto designed for businesses seeking prominent exposure on a major downtown road.

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Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics

Based on your search, we've compiled 17 Potential Opportunities for your consideration. Besides 3 Active listings in Palmetto, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 8 Properties for Sales.

Office Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Office Unit with Signage

7210 US 301 N, Ellenton, FL 34222

$26 SF/Yr

850 sqft

Available suite offers an open work area, private office, shared facilities, and prominent US 301 frontage.

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Office Building with Fenced Yard

7210 US 301 N, Ellenton, FL 34222

Contact for pricing

6,500 sqft

Two-parcel office property with month-to-month occupancy, executive suites, and a separate warehouse.

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Stand-Alone Medical Office Building

410 4th Ave E, Bradenton, FL 34208

Contact for pricing

2,108 sqft

Stand-alone medical/office building with check-in reception, private and open areas, and nine designated parking spaces.

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Class A Riverfront Office Space

101 Riverfront Blvd, Bradenton, FL 34205

$14.25 SF/Yr

Premier office space with Manatee River views and convenient access.

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Similar Spaces for Sale in Palmetto, FL

Consider Similar Space for Sale. We found 8 Spaces matching your search parameters.

Leased Medical Office with Exam Rooms

506 4TH Avenue W, Palmetto, FL 34221

$845,000

3,171 sqft 0.60 AC lot

A single-tenant medical practice occupies the property under a NNN lease with annual escalations and renewal options.

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Leased Medical Office Building

506 4TH AVENUE W, Palmetto, FL 34221

$845,000

3,213 sqft

Single-tenant medical office with a purpose-built clinical layout and recently installed HVAC systems.

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Palmetto Medical Building on 2.24 Acres

602 4th Avenue West, Palmetto, FL 34221

$2,000,000

16,382 sqft 2.24 AC lot

Strategically located medical building with flexible space and expansion potential.

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High-Visibility Land on Moccasin Wallow

2519 Moccasin Wallow Rd, Palmetto, FL 34221

$1,199,999

1,080 sqft 2.50 AC lot

2.5 acre parcel with road frontage in rapidly growing area.

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High-Visibility Land on Moccasin Wallow

2519 MOCCASIN WALLOW ROAD, Palmetto, FL 34221

$1,199,999

2.49 AC lot

Prime ~2.5 acre parcel with road frontage in growing Parrish.

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Single-Tenant Medical Office

506 4TH W, Palmetto, FL 34221

$845,000

Purpose-built medical space leased under an NNN structure with renewal options and recently upgraded HVAC systems.

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Palmetto Mixed-Use Development Opportunity

834 RIVERSIDE, Palmetto, FL 34221

$3,500,000

3.40 AC lot

Development site near Manatee River suitable for mixed-use projects.

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Palmetto 52-Acre Assemblage Opportunity

1321 77th St E, Palmetto, FL 34221

Contact for pricing

16,443 sqft 52.00 AC lot

52 acres with buildings, prime location, development potential.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Commercial Land Near Shopping

6012 LORRAINE Road, Bradenton, FL 34211

$21,000/Mo

4.67 AC lot

Commercial land positioned near shopping in Bradenton, Florida.

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Commercial Land Near Signalized Intersection

2305 N NEBRASKA Avenue, Tampa, FL 33602

$6,000/Mo

0.45 AC lot

Commercial land with YC-5 zoning, public utilities, and access to established Tampa corridors.

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Palmetto, FL Office Spaces Lease Rates & Market Statistics

Explore 3 Office Spaces for lease in Palmetto, FL on Realmo, a commercial real estate exchange covering the Palmetto area. The current inventory totals 12,195 square feet of properties.

Asking lease rates for Office Spaces in Palmetto start at $4.23 SF/Yr, average $15.41 SF/Yr, and reach $22 SF/Yr at the top of the market. That's a 5x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $15.41 SF/Yr is 56% below the Florida state average of $34.69 SF/Yr.

Palmetto accounts for 4% of the 82 office spaces currently available across Manatee County, where nearby markets include Bradenton and Sarasota.