Palmetto, FL Commercial real estate for Rent & Lease

$4,000/Mo

11,345 SF

Modern Office Suite on US-41

10305 US HIGHWAY 41 N, Palmetto, FL 34221

Turnkey office suite with modern finishes and excellent location.

Prime location on S Tamiami Trail (US‑41) with high visibility and easy access.
Turnkey, modern 1,206 sq. ft. office suite ready for immediate occupancy.
Three large private offices, spacious reception area, private bathroom, and dedicated kitchen.
Strategically located 1.5 miles north of I‑275, providing easy access to St. Petersburg, Tampa, and Sarasota.
High‑standard finishes including luxury vinyl flooring, modern lighting, and large windows with privacy treatments.

Updated: May 3

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$18 SF/Yr

2,640 SF

Stand Alone Building For Lease

1331 10th St E, Palmetto, FL

Stand-alone building suitable for office, medical, or retail use.

Stand‑alone building: Only stand‑alone building in River North Business Center.
Flexible zoning: CG zoning designation suitable for office, medical, or retail use.
Ample parking: Abundance of parking spaces available for customers and employees.
Functional floorplan: Includes 10 private offices, reception area, open area, kitchenette, and 2 handicap restrooms.
Strategic location: Located between US 41/Business 41 and I‑75, with easy access to I‑275.

Updated: Oct 28, 2025

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$22 SF/Yr

2,750 SF

Retail Space Available for Lease

Retail/office space available for lease with great signage.

937 10th St E, Palmetto, FL

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$2.00 SF/Yr

Retail/Office Unit on 8th Avenue

Highly visible retail/office unit with front and rear access.

835 8TH Ave W, Palmetto, FL 34221

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$2,950,000 SF/Yr

Industrial Warehouse For Lease

Industrial warehouse available for lease at 1330 10th Street East in Palmetto, Florida.

1330 10th Street East, Palmetto, FL 34221

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$1,250,000 SF/Yr

Warehouse for Lease

Industrial warehouse space offered for rent with convenient access to major interstate routes.

1611 18th Avenue Dr E, Palmetto, FL 34221

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$48,000 SF/Yr

1,206 SF

Retail Space For Rent

Retail space available for lease in Palmetto, Florida.

10305 US HIGHWAY 41 N, Palmetto, FL 34221

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450 SF

Office Suite on 49th Street

450 SF office suite with frontage on 49th Street.

818 49th Street East, Palmetto, FL 34221

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2,240 SF

Palmetto Retail/Flex Space Available

Versatile 2,240 SF retail/flex space in Palmetto, Florida.

925 10th St E, Palmetto, FL 34221

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$20 SF/Yr

4,400 SF

Retail Space in Palmetto, FL

Freestanding retail building in a high-traffic area for lease.

1210 St E, Palmetto, FL

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2,035 SF

Resort Retail Space Available

Retail spaces and pads for lease in Marriott Resort Hotel.

650 US Hwy 41 N, Palmetto, FL

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6,500 SF

Resort Retail Space Available

Retail spaces and pads for lease in Marriott Resort Hotel.

600 US Hwy 41 N, Palmetto, FL

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Tilt-Wall Industrial Distribution Center

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187,200 SF

Tilt-Wall Industrial Distribution Center

Three tilt-wall distribution buildings offer flexible unit sizes with direct connectivity to major highways.

11805 US 41, Palmetto, FL 34221

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$5,000/Mo

1,600 SF

Palmetto Industrial Land with Canopy

Industrial land with canopy and modular office for lease.

1908 13th St E, Palmetto, FL

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Corner Parcel Near Future Grocer

Commercial land for rent near major roads and future development.

9620 36th Ave E, Palmetto, FL 34221

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Based on your search, we've compiled 72 Potential Opportunities for your consideration. Besides 15 Active listings in Palmetto, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 53 Properties for Sales.

Commercial real estate for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

$24 SF/Yr

900 SF

Medical Office Space Near Hospital

Medical office suites available near Manatee Memorial Hospital in Bradenton.

201 4th Ave E, Bradenton, FL 34208

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$1,100/Mo

750 SF

Ellenton Business Park Units

Flex and warehouse spaces available for lease in Ellenton.

Bradenton, FL

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$14 SF/Yr

5,871 SF

Class A Riverfront Office Space

Premier office space with Manatee River views and convenient access.

101 Riverfront Blvd, Bradenton, FL

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Professional Office Building in Riverwalk

Well-maintained office building near Manatee Memorial Hospital and downtown Bradenton.

100 3rd Avenue W., Bradenton, FL 34205

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Similar Spaces for Sale in Palmetto, FL

Consider Similar Space for Sale. We found 53 Spaces matching your search parameters.

Waterfront Restaurant Opportunity on US 19

$2,500,000

5,247 SF

Waterfront Restaurant Opportunity on US 19

Prime waterfront property with high visibility and renovation potential.

5611 US HIGHWAY 19, Palmetto, FL 34221

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$1,299,999

1,080 SF

High-Visibility Land Parcel on Moccasin

Prime ~2 acre parcel with road frontage in rapidly growing area.

2519 MOCCASIN WALLOW ROAD, Palmetto, FL 34221

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$1,299,999

1.96 Acres

High-Visibility Land on Moccasin Wallow

Prime land parcel with frontage on rapidly growing Moccasin Wallow.

2519 MOCCASIN WALLOW ROAD, Palmetto, FL 34221

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$289,000

0.03 Acres

Riviera Dunes Marina Slip Available

70' boat slip in a protected Florida marina.

102 RIVIERA DUNES WAY, Palmetto, FL 34221

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Palmetto Equestrian Center with 20 Stalls

$1,500,000

3,946 SF

Palmetto Equestrian Center with 20 Stalls

4.9 acre horse ranch with Mediterranean home and guest house.

9510 36TH AVENUE E, Palmetto, FL 34221

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$2,790,000

16,382 SF

Palmetto Medical Building on 2.24 Acres

Strategically located medical building with flexible space and expansion potential.

602 4th Avenue West, Palmetto, FL 34221

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Waterfront Redevelopment Opportunity in Palmetto

$9,950,000

10.32 Acres

Waterfront Redevelopment Opportunity in Palmetto

Waterfront property with redevelopment potential, marina, and navigable water access.

6817 Bayshore Road, Palmetto, FL 34221

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$1,299,999

1,080 SF

High-Visibility Land on Moccasin Wallow

2.5 acre parcel with road frontage in rapidly growing area.

2519 MOCCASIN WALLOW ROAD, Palmetto, FL 34221

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$2,400,000

8.30 Acres

Manatee County Development Site

Commercial development site in a rapidly growing area.

9750 Bud Rhoden Rd., Palmetto, FL 34221

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Palmetto, FL Commercial real estate Leasing Opportunities Market Analysis

Explore Commercial real estate leasing options in Palmetto, FL with 15 listings featured on our commercial real estate exchange. The current inventory includes 23,941 square feet of properties with an estimated lease value of $48,101.

Estimated lease rates for Commercial real estate in Palmetto, FL begin at $4 SF/Yr, with an average of $8,016 /Mo and extend to $48,000.

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