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Santa Cruz, CA

Office

Santa Cruz, CA Office Spaces for Lease

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Capitola, CA Scotts Valley, CA Aptos, CA Boulder Creek, CA Watsonville, CA Freedom, CA Los Gatos, CA Saratoga, CA

15 properties

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Downtown Class A Office Suites

Updated: Jul 24

Downtown Class A Office Suites

133 Mission St, Santa Cruz, CA 95060

$4,909/Mo

4,909 sqft

Class A office space in downtown Santa Cruz, available now
Free parking available at 4 per 1,000 SF
Available suites: Suite 220 (~1,053 SF), Suite 210 (~2,668 SF), Suite 230 (~1,170 SF), Suite 240 (~1,266 SF)
Multi‑suite option: Suite 210+220+230+240 totaling approximately 6,157 SF

Available Office Unit

Updated: Aug 1

Available Office Unit

133 Mission St, Suite 280, Santa Cruz, CA 95060

$4,909/Mo

4,909 sqft

Office unit available now
Suite 280 at 133 Mission St, Santa Cruz, CA 95060
Listed property size of 4,909

Santa Cruz Office Space Available

Santa Cruz Office Space Available

133 Mission St, Suite 210, Santa Cruz, CA 95060

$2,668/Mo

2,668 sqft

Office space available for rent in Santa Cruz, CA.

Elevator-Served Office Units

Elevator-Served Office Units

1121-1125 Pacific Ave, Santa Cruz, CA 95060

Contact for pricing

10,204 sqft

Flexible professional workspace with modern amenities, elevator service, and abundant natural light.

Medical Office Space with Clinic History

Medical Office Space with Clinic History

220 Leibrandt Ave, Santa Cruz, CA 95060

Contact for pricing

1,560 sqft

Former dental clinic space identified for office, medical, dental, veterinary, and retail uses.

Freestanding Single-Tenant Office

Freestanding Single-Tenant Office

617 Water St, Santa Cruz, CA 95060

Contact for pricing

1,500 sqft

Freestanding office features a large entry open area, full kitchen/break area, multiple private offices, and 6 parking spaces.

Grade-Level Office Space

Grade-Level Office Space

601 Swift St, Santa Cruz, CA 95060

Contact for pricing

20,200 sqft

Turnkey office suite with robust 1,200-amp power service and surface parking available starting August 15, 2026.

Santa Cruz Office Space Available

Santa Cruz Office Space Available

550 Water St, Santa Cruz, CA

Contact for pricing

950 sqft 0.66 AC lot

950 SF office space with ample parking in Santa Cruz.

Downtown Office Space with Parking

Downtown Office Space with Parking

1543 Pacific Ave, Santa Cruz, CA 95060

Contact for pricing

Flexible office layout includes private offices, open work areas, conference room, and two restrooms, with on-site parking.

Mixed-Use Property

Mixed-Use Property

101 Church Street, Santa Cruz, CA 95060

Contact for pricing

Commercial space combines office and retail functions in a lease offering.

Mixed-Use Property with Signage

Mixed-Use Property with Signage

6894 Soquel Avenue, Santa Cruz, CA 95062

Contact for pricing

Retail, office, and professional service uses are identified for this Soquel Avenue space.

Equipped Lab and Office Space

Equipped Lab and Office Space

250 Natural Bridges Dr, Santa Cruz, CA

Contact for pricing

6,750 sqft 0.91 AC lot

6,750 SF lab and office space for rent.

Professional Office Suites for Lease

Professional Office Suites for Lease

500 Chestnut St, Santa Cruz, CA

Contact for pricing

971 sqft 0.30 AC lot

Multiple office suites available in professional building with natural light.

Downtown Santa Cruz Office Space

Downtown Santa Cruz Office Space

1200 Pacific Ave, #Ground Floor, Santa Cruz, CA 95060

Contact for pricing

Office space for rent in the heart of Santa Cruz.

Renovated Office Space Available

Renovated Office Space Available

903 Pacific Ave, Santa Cruz, CA

Contact for pricing

559 sqft 0.17 AC lot

Newly renovated office suites with elevator access, natural light.

Based on your search, we've compiled 31 Potential Opportunities for your consideration. Besides 15 Active listings in Santa Cruz, CA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 12 Properties for Sales.

Office Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Office Space for Lease

Office Space for Lease

2 Santa Cruz Ave N., Los Gatos, CA 95030

Contact for pricing

1,787 sqft

Office space offered for lease at 2 Santa Cruz Ave N. in Los Gatos.

Renovated Office Space in Scotts

Renovated Office Space in Scotts

5011 Scotts Valley Dr, Scotts Valley, CA

Contact for pricing

2,500 sqft 0.25 AC lot

2500 sq ft office space with high ceilings.

Scotts Valley Flex Space Available

Scotts Valley Flex Space Available

108 Whispering Pines Dr, Scotts Valley, CA

Contact for pricing

4,800 sqft 1.60 AC lot

4800 SF flex space for sublease in Scotts Valley.

Open Office Suite

Open Office Suite

50 University Ave, Los Gatos, CA 95030

Contact for pricing

571 sqft

Open office buildout available immediately in a suite adjacent to restaurants and retail services.

Similar Spaces for Sale in Santa Cruz, CA

Consider Similar Space for Sale. We found 12 Spaces matching your search parameters.

Victorian Office Building

Victorian Office Building

603 Mission ST, Santa Cruz, CA 95060

$2,535,000

5,923 sqft 0.41 AC lot

Historic commercial property with private offices, meeting areas, and a separate residential unit above office space.

Two-Tenant Medical Office Space

Two-Tenant Medical Office Space

3141 Paul Sweet Road, Santa Cruz, CA 95065

$1,395,000

2,071 sqft

Adjacent to Dominican Hospital, the professional-office layout includes natural light, central air, and flexible occupancy configuration.

Three-Unit Retail Office Building

Three-Unit Retail Office Building

Santa Cruz, CA 95060

$4,950,000

10,204 sqft

Three-unit building with retail and office spaces, built in 1980, zoned CBD, 100% occupied and professionally managed.

Victorian Mixed-Use Office Property

Victorian Mixed-Use Office Property

603 Mission ST, Santa Cruz, CA 95060

$2,535,000

0.41 AC lot

Commercial zoning supports an office configuration with a separate residential unit.

Single-Story Medical Office

Single-Story Medical Office

3811 Portola DR, Santa Cruz, CA 95062

$3,149,000

0.50 AC lot

The property has C-2 zoning, public water, and covered and off-street parking.

Medical Office Property with Vacant Lot

Medical Office Property with Vacant Lot

3811 Portola DR, Santa Cruz, CA 95062

$3,149,000

0.50 AC lot

Single-story medical office with treatment rooms, flexible space, adjoining land, and on-site parking.

Two-Story Office Building with Elevator

Two-Story Office Building with Elevator

2880 Soquel Ave, Santa Cruz, CA 95062

Contact for pricing

18,000 sqft

Two-story, well-maintained office building with elevator and ample parking, served by AT&T fiber.

Recently Renovated Office Building

Recently Renovated Office Building

550 Water St, Santa Cruz, CA 95060

Contact for pricing

800 sqft

Recently renovated office building offers abundant natural light and high ceilings across 800 square feet.

Santa Cruz Office Space Available

Santa Cruz Office Space Available

2880 Soquel Ave, Santa Cruz, CA

Contact for pricing

9,000 sqft 1.23 AC lot

Highly visible office space for lease in Santa Cruz.

Santa Cruz, CA Office Spaces Lease Rates & Market Statistics

Browse 15 Office Spaces for lease in Santa Cruz, CA on Realmo, a commercial real estate marketplace serving the Santa Cruz area. The current inventory totals 55,180 square feet of properties — an average of ~3,700 SF per listing.

Asking lease rates for Office Spaces in Santa Cruz start at $12 SF/Yr, average $12 SF/Yr, and reach $12 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. At $12 SF/Yr, the local average runs 51% below California's state average of $24.62 SF/Yr.

Santa Cruz accounts for 48% of the 31 office spaces currently available across Santa Cruz County, where nearby markets include Scotts Valley and Los Gatos. By space type, the market includes 10 office units and 3 office buildings.

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