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    Santa Cruz, CA Commercial Real Estate for Lease

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    51 properties
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    Available Office Unit
    Updated: Aug 1
    Available Office Unit

    133 Mission St, Suite 280, Santa Cruz, CA 95060

    $4,909/Mo
    4,909 sqft
    Office unit available now
    Suite 280 at 133 Mission St, Santa Cruz, CA 95060
    Listed property size of 4,909
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    Santa Cruz Office Space Available
    Updated: Apr 4
    Santa Cruz Office Space Available

    133 Mission St, Suite 210, Santa Cruz, CA 95060

    $2,668/Mo
    2,668 sqft
    Available now
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    Medical Office Space with Parking
    Medical Office Space with Parking

    3315 Mission Dr, Santa Cruz, CA 95065

    Contact for pricing
    1,340 sqft

    Healthcare-oriented suite with onsite parking near Dominican Hospital and Sutter Health.

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    Freestanding Single-Tenant Office
    Freestanding Single-Tenant Office

    617 Water St, Santa Cruz, CA 95060

    Contact for pricing
    1,500 sqft

    Freestanding office features a large entry open area, full kitchen/break area, multiple private offices, and 6 parking spaces.

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    Downtown Santa Cruz Retail Space
    Downtown Santa Cruz Retail Space

    701 Front St, Santa Cruz, CA 95060

    Contact for pricing
    2,360 sqft

    Prime retail space in downtown Santa Cruz with high traffic.

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    Grade-Level Office Space
    Grade-Level Office Space

    601 Swift St, Santa Cruz, CA 95060

    Contact for pricing
    20,200 sqft

    Turnkey office suite with robust 1,200-amp power service and surface parking available starting August 15, 2026.

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    Retail Shopping Center with Parking
    Retail Shopping Center with Parking

    580 River St, Santa Cruz, CA 95060

    Contact for pricing
    1,372 sqft

    Shopping center offering 498 dedicated parking stalls and major retail anchors including ROSS, PetSmart, and Cost Plus World Market.

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    Downtown Class A Office Suites
    Downtown Class A Office Suites

    133 Mission St, Santa Cruz, CA 95060

    Contact for pricing
    2,668 sqft

    Class A office suites are available now in downtown Santa Cruz, with free parking included.

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    Downtown Office Space with Parking
    Downtown Office Space with Parking

    1543 Pacific Ave, Santa Cruz, CA 95060

    Contact for pricing
    4,371 sqft

    Flexible office layout includes private offices, open work areas, conference room, and two restrooms, with on-site parking.

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    Retail Space in Santa Cruz
    Retail Space in Santa Cruz

    414 Front St, Santa Cruz, CA 95060

    Contact for pricing
    11,479 sqft

    Retail space available for lease in Santa Cruz, CA.

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    Mixed-Use Village with Retail Courtyard
    Mixed-Use Village with Retail Courtyard

    300 Ingalls St, Santa Cruz, CA 95060

    Contact for pricing
    5,000 sqft

    Planned mixed-use community includes three 4-story residential buildings and a retail plaza with an outdoor courtyard.

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    Office Units with Private Restrooms
    Office Units with Private Restrooms

    550 Water St, Santa Cruz, CA 95060

    Contact for pricing
    950 sqft

    Three bright office suites provide private restroom access and ample parking for commercial occupants.

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    Flex Space with Office Area
    Flex Space with Office Area

    601 Swift St, Santa Cruz, CA 95060

    Contact for pricing
    20,200 sqft

    Industrial-flex property includes office space, substantial electrical service, PG&E utilities, and surface parking.

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    Live Oak Warehouse Space Available
    Live Oak Warehouse Space Available

    1555 Mansfield St, Santa Cruz, CA 95062

    Contact for pricing
    2,640 sqft

    2640 SF warehouse in Live Oak for lease.

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    Retail Space on Pacific Avenue
    Retail Space on Pacific Avenue

    1117 Pacific Ave, Santa Cruz, CA 95060

    $15 SF/Yr

    Retail space available for rent on Pacific Avenue.

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    Santa Cruz Office Space Available
    Santa Cruz Office Space Available

    550 Water St, Santa Cruz, CA

    Contact for pricing
    950 sqft 0.66 AC lot

    950 SF office space with ample parking in Santa Cruz.

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    Retail Space with Dual Street Entrances
    Retail Space with Dual Street Entrances

    1115-1117 Pacific Ave, Santa Cruz, CA 95060

    Contact for pricing
    8,000 sqft

    CBD-zoned retail space in a downtown parking district with ground-floor access from two street-level entrances.

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    Downtown Retail Space Available
    Downtown Retail Space Available

    1115-1117 Pacific Ave, Santa Cruz, CA

    Contact for pricing
    3,500 sqft 0.18 AC lot

    Retail space in a vibrant downtown location on Pacific Avenue.

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    Westside Flex Space with Mezzanine
    Westside Flex Space with Mezzanine

    411 Ingalls St, Santa Cruz, CA

    Contact for pricing
    4,000 sqft 0.25 AC lot

    Flexible industrial space with mezzanine in prime westside location.

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    Riverwalk Retail in Mixed-Use Development
    Riverwalk Retail in Mixed-Use Development

    444 Front St, Santa Cruz, CA 95060

    Contact for pricing
    1,763 sqft

    Street-level and riverwalk retail access within a mixed-use project that includes modern residential units.

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    Retail Space in New Complex
    Retail Space in New Complex

    350 Ocean St, Santa Cruz, CA

    Contact for pricing
    965 sqft 1.54 AC lot

    Retail storefronts in a high-traffic, walkable Santa Cruz location.

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    Santa Cruz Office Space Available
    Santa Cruz Office Space Available

    1667 Dominican Way, Santa Cruz, CA

    Contact for pricing
    768 sqft 0.03 AC lot

    Office space for rent in prime Santa Cruz location.

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    Mixed-Use Riverfront Retail Space
    Mixed-Use Riverfront Retail Space

    444 Front St, Santa Cruz, CA 95060

    Contact for pricing
    498 sqft

    Street-level and riverwalk retail access totaling 10,173 sf within a mixed-use project featuring 175 residential units.

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    Mixed-Use Development Retail Space
    Mixed-Use Development Retail Space

    418-508 Front St, Santa Cruz, CA

    Contact for pricing
    1,744 sqft 1.04 AC lot

    Retail space in a mixed-use development with residential units.

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    Santa Cruz, CA Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in Santa Cruz, CA with 51 listings featured on our commercial real estate exchange. The current inventory includes 167,011 square feet of properties with an estimated lease value of $120.

    Estimated lease rates for Commercial real estate in Santa Cruz, CA begin at $12 SF/Yr, with an average of $24 SF/Yr and extend to $42 SF/Yr.
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