Fredericktown, MO Mixed-use properties for sale

Updated: Nov 6, 2025

Historic Mixed-Use Storefronts

140-142 E Main Street, Fredericktown, MO 63645

$269,999

Five historic storefronts included in the offering
Upper floors previously used for apartments, workspaces, and storage
Street‑level commercial storefront configuration
Corner location in downtown Fredericktown
Built in 1900

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Based on your search, we've compiled 76 Potential Opportunities for your consideration. Besides 1 Active listings in Fredericktown, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 71 Off-Market properties to explore as potential leads

Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Mixed-Use Commercial Building

4042 Jeffco Blvd, Arnold, MO 63010

Contact for pricing

19,600 sqft

CC-2 zoning supports office, warehouse, retail, and service uses.

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Mixed-Use Property

1556 Jeffco Boulevard, Arnold, MO 63010

Contact for pricing

10,000 sqft

For sale mixed-use property totaling 10,000 SF at 1556 Jeffco Boulevard in Arnold, Missouri.

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Renovated Mixed-Use Property

226 N Sprigg Street, Cape Girardeau, MO 63701

$285,000

Fully leased building combines a remodeled commercial level with a newly constructed residential loft.

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Three-Unit Mixed-Use Property

401 S West End Boulevard, Cape Girardeau, MO 63703

$299,000

Income-producing layout combines residential occupancy, short-term rental use, and commercial space.

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Off-Market Properties in Fredericktown, MO

Consider similar Off-Market properties in Fredericktown, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

STORE/OFFICE (MIXED USE)

807 Main St, Fredericktown, MO 63645-8559

$500,000

$65,000

Estimated value

5,000 sqft 0.84 AC lot

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OFFICE/RESIDENTIAL (MIXED USE)

322 Schulte Ln, Fredericktown, MO 63645-1038

Value Estimation by Request

0.62 AC lot

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STORE/OFFICE (MIXED USE)

1009 High St, Fredericktown, MO 63645-8837

Value Estimation by Request

7,740 sqft 0.31 AC lot

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OFFICE/RESIDENTIAL (MIXED USE)

209 Lincoln Dr, Fredericktown, MO 63645-7553

Value Estimation by Request

2,912 sqft 0.27 AC lot

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OFFICE/RESIDENTIAL (MIXED USE)

26 Ct Sq, Fredericktown, MO 63645-1109

Value Estimation by Request

10,900 sqft 0.36 AC lot

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STORE/OFFICE (MIXED USE)

210 Murta St, Fredericktown, MO 63645-1018

$1,020,000

Estimated value

43,866 sqft 4.56 AC lot

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STORE/OFFICE (MIXED USE)

Fredericktown, MO 63645

Value Estimation by Request

25,162 sqft 1.62 AC lot

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STORE/OFFICE (MIXED USE)

1572 Madison 505, Fredericktown, MO 63645

Value Estimation by Request

2,500 sqft 3.06 AC lot

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STORE/OFFICE (MIXED USE)

126 Main St, Fredericktown, MO 63645-1124

Value Estimation by Request

6,034 sqft 0.18 AC lot

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STORE/OFFICE (MIXED USE)

409 Main St, Fredericktown, MO 63645-1168

Value Estimation by Request

4,290 sqft 0.60 AC lot

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STORE/OFFICE (MIXED USE)

Commercial Dr, Fredericktown, MO 63645

Value Estimation by Request

12,164 sqft 2.50 AC lot

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Fredericktown, MO Mixed-use Properties for Sale

140-142 E Main Street, Fredericktown, MO 63645