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    Fredericktown, MO
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    Fredericktown, MO Commercial Real Estate for Sale

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    Marquand, MO Farmington, MO Perryville, MO
    47 results
    Restored Train Depot Restaurant
    $499,999
    1,900 SF

    Restored Train Depot Restaurant

    406 Villar, Fredericktown, MO 63645

    Established restaurant in a restored early 1900s train depot.

    • Fully operational restaurant with all standard equipment included, ready for immediate business.
    • Historic train depot location with unique ambiance and beautifully restored design.
    • Well‑established restaurant with a reputation for outstanding food quality and attentive service.
    • Seating for 54 guests plus 6 bar seats, along with outdoor patio seating.
    • Ample parking for customers and convenient curb side pick‑up for carry‑out orders.
    Updated: Oct 17, 2025
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    Versatile Commercial Building in Fredericktown
    $185,000
    1,170 SF

    Versatile Commercial Building in Fredericktown

    120 E College, Fredericktown, MO 63645

    Adaptable commercial space with multiple configurations and recent updates.

    • Versatile building configurable for up to three separate businesses or one large operation.
    • Each unit has a private office space, restroom, and entrance.
    • Corner lot location with ample off‑street parking.
    • Close proximity to downtown Fredericktown.
    • Updated roof (approximately one year ago).
    Updated: Mar 24
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    Secluded Home on Wooded Acreage
    $574,900
    1,344 SF

    Secluded Home on Wooded Acreage

    Modern home on 69+/- acres near Fredericktown, Missouri.

    2101 Madison 9236, Fredericktown, MO 63645
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    82-Acre Farm with Highway Access
    $750,000
    1,536 SF

    82-Acre Farm with Highway Access

    Farmhouse and outbuildings on 82 acres near Highway 67.

    1044 Madison 9203, Fredericktown, MO 63645
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    Fredericktown Commercial Opportunity For Sale
    $137,500
    0.11 Acres

    Fredericktown Commercial Opportunity For Sale

    High-traffic commercial property with flexible layout in growing community.

    211 Lincoln Drive, Fredericktown, MO 63645
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    Prime Commercial Land in Fredericktown
    $159,000
    1,538 SF

    Prime Commercial Land in Fredericktown

    Exceptional commercial property in downtown Fredericktown, ideal for office space.

    152 South Main, Fredericktown, MO 63645
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    Secluded Acreage with Cabin and Creek
    $119,900
    15.58 Acres

    Secluded Acreage with Cabin and Creek

    15.58 acres with cabin, orchard, creek near Castor River.

    Tract 3 Madison 248, Fredericktown, MO 63645
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    Fredericktown Farm with Creek Access
    $109,900
    14.31 Acres

    Fredericktown Farm with Creek Access

    14.31 acres with creek, near conservation area.

    Tract 2 Madison 248, Fredericktown, MO 63645
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    Commercial Land Near Highway
    $385,000
    3.38 Acres

    Commercial Land Near Highway

    3.38 acre commercial land in high-traffic location.

    0 Huddle House Drive, Fredericktown, MO 63645
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    8.847 Acres Near National Forest
    Contact for pricing
    8.85 Acres

    8.847 Acres Near National Forest

    Wooded property near Mark Twain National Forest with no restrictions.

    62 Madison CR 410, Fredericktown, MO 63645
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    Fredericktown Redevelopment Opportunity
    $595,000
    23,166 SF

    Fredericktown Redevelopment Opportunity

    Vacant 23,166 SF building on 1.62 acres for sale.

    208 Lincoln Drive, Fredericktown, MO 63645
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    6.197 Acres Near National Forest
    Contact for pricing
    6.20 Acres

    6.197 Acres Near National Forest

    Wooded 6.197 acre property near Mark Twain National Forest.

    60 Madison CR 410, Fredericktown, MO 63645
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    20 Acre Farm with Living
    $385,000
    20.00 Acres

    20 Acre Farm with Living

    20 acre farm featuring barns, cabin, and living quarters.

    100 Cool Breeze Lane, Fredericktown, MO 63645
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    Wooded Acreage Near National Forest
    $39,995
    9.24 Acres

    Wooded Acreage Near National Forest

    9.242 acres near Mark Twain National Forest.

    52 Madison CR 410, Fredericktown, MO 63645
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    Wooded Acreage Near National Forest
    Contact for pricing
    7.91 Acres

    Wooded Acreage Near National Forest

    7.9 acres of wooded land close to Mark Twain Forest.

    54 Madison CR 410, Fredericktown, MO 63645
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    Commercial Land in Fredericktown, MO
    $995,000
    54.72 Acres

    Commercial Land in Fredericktown, MO

    54.2 +/- acres of commercially zoned land for sale.

    Tract 5 off Hwy 72 Bypass, Fredericktown, MO 63645
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    Picturesque Land with Creek Frontage
    $239,400
    53.20 Acres

    Picturesque Land with Creek Frontage

    53.2 acre tract with ponds, springs, and electricity.

    0 Madison 441, Fredericktown, MO 63645
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    Wooded Acreage Near National Forest
    Contact for pricing
    5.85 Acres

    Wooded Acreage Near National Forest

    Affordable 5.845 acres near Mark Twain National Forest.

    85 Madison CR 410, Fredericktown, MO 63645
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    Ozark Land with Spring-Fed Creek
    $49,900
    2.50 Acres

    Ozark Land with Spring-Fed Creek

    2.5+/- acres with creek, camping spot near Mark Twain Forest.

    129 Madison CR 410, Fredericktown, MO 63645
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    Commercial Land Near Highway 67
    $150,000
    1.00 Acre

    Commercial Land Near Highway 67

    One acre commercial property near Hwy 67 in Fredericktown, MO.

    Tract 3 off Emerald Bluff Drive, Fredericktown, MO 63645
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    Fredericktown Commercial Land Opportunity
    $150,000
    1.04 Acres

    Fredericktown Commercial Land Opportunity

    1.04 acre commercial land with highway visibility.

    Tract 4 off Hwy 72 Bypass, Fredericktown, MO 63645
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    420-Acre Farm with Hunting Cabin
    $2,944,000
    420.00 Acres

    420-Acre Farm with Hunting Cabin

    Large, fenced farm with timber, fields, pond, and creek frontage.

    9556 Madison 535, Fredericktown, MO 63645
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    Fredericktown Commercial Land For Sale
    $195,000
    1.84 Acres

    Fredericktown Commercial Land For Sale

    1.84 acre commercial lot with road frontage on 3 sides.

    Tract 2 off Emerald Bluff Dr, Fredericktown, MO 63645
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    Secluded Wooded Acreage Near National Forest
    Contact for pricing
    5.37 Acres

    Secluded Wooded Acreage Near National Forest

    5.366 acres of wooded land with shared creek access.

    163 Madison CR 410, Fredericktown, MO 63645
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    Fredericktown, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 583 commercial real estate for sale in Fredericktown, MO, showcased through 47 active listings on our real estate platform. These investment opportunities span a total of 100,142 square feet of properties for sale, with an estimated market value of $5,148,899.

    Sale prices for business properties in Fredericktown, MO start at $159,000, averaging $572,099, and reaching up to $1,750,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Operating Costs & Financing

    Average Loan-to-Value 65.0%

    Fredericktown Demographics Overview

    Population 12K
    Population Growth (5Y) +0.4%
    Median Household Income $57,862
    College Educated 21.9%

    High-Yield Neighborhoods for Strategic Investment

    Identify Fredericktown submarkets with the highest inventory density on the market and evaluate the median listing prices of real estate assets

    Neighborhood Average Price
    63645 $284.8K

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