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    Florence, CO Mixed-use Properties for Sale

    10 results
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    Mixed-Use Property on Main Street
    $225,000
    0.47 Acres

    Mixed-Use Property on Main Street

    305 W Main St, Florence, CO 81226

    Versatile property with residential and commercial potential in Florence, CO.

    • High‑visibility corner lot on State Highway 115 (Main Street) ideal for commercial ventures.
    • Income‑generating property with potential for over $2,000/month in rental income.
    • Versatile property suitable for residential rentals, commercial operations, or a combination of both.
    • Includes a 1,004‑square‑foot commercial garage with bathroom and parts room.
    • Features a 616‑square‑foot studio apartment with a newer roof and 3/4 bath.
    Updated: Dec 8, 2025
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    Historic Mixed-Use Building with Loft
    $480,000
    2,850 SF

    Historic Mixed-Use Building with Loft

    119 Main St, Florence, CO 81226

    Main Street investment opportunity with business spaces and luxury loft.

    • Investment opportunity: Two business spaces plus a nearly‑finished 2 bed, 2 bath luxury loft.
    • Prime location on Main Street in Historic Downtown Florence.
    • Unique historic building: Original fire station and City Hall with original brick walls and arched windows.
    • Ample free customer parking on Main Street and additional parking with alley access.
    • Close proximity to breweries, galleries, restaurants, and shopping.
    Updated: Oct 30, 2025
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    Mixed-Use Building in Florence, CO
    $300,000

    Mixed-Use Building in Florence, CO

    Classic mixed-use building with remodeling potential on Main Street.

    108 W Main St, Florence, CO 81226
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    Historic Downtown Florence Live-Work Space
    $675,000
    0.08 Acres

    Historic Downtown Florence Live-Work Space

    Live-work investment opportunity in historic downtown Florence, Colorado.

    122 W Main St, Florence, CO 81226
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    Historic Downtown Florence Mixed-Use Building
    $480,000
    0.08 Acres

    Historic Downtown Florence Mixed-Use Building

    Mixed-use building with business spaces and luxury loft in Florence.

    119 W Main St, Florence, CO 81226
    View details
    Mixed-Use Investment in Historic Downtown
    $675,000
    0.08 Acres

    Mixed-Use Investment in Historic Downtown

    Live-work investment opportunity in Florence's Historic Downtown on Main Street.

    122 W Main St, Florence, CO 81226
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    Mixed-Use Building in Florence, CO
    $300,000
    0.17 Acres

    Mixed-Use Building in Florence, CO

    Classic mixed-use building with remodeling potential on Main Street.

    108 W Main St, Florence, CO 81226
    View details
    Florence Main Street Mixed-Use Gem
    $350,000
    0.18 Acres

    Florence Main Street Mixed-Use Gem

    Historic building, high potential, 16,000+ sq ft.

    108 Main St, Florence, CO 81226
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    119 Main St, Florence, CO 81226
    $495,000
    0.08 Acres

    119 Main St, Florence, CO 81226

    Mixed-use properties • 0.08 Acres

    119 Main St, Florence, CO 81226
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    Prime Florence Mixed-Use Opportunity
    $675,000
    0.22 Acres

    Prime Florence Mixed-Use Opportunity

    Main Street gem: 5 income streams!

    Main St, Florence, CO 81226
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    Based on your search, we've compiled 17 Potential Opportunities for your consideration. Besides 10 Active listings in Florence, CO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 3 Off-Market properties to explore as potential leads

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Mixed-Use Building in Canon City
    $650,000
    0.64 Acres

    Mixed-Use Building in Canon City

    Mixed-use property with commercial and residential units near downtown.

    1415 Main St, Canon City, CO 81212
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    Mixed-Use Building on Highway Frontage
    $650,000
    0.22 Acres

    Mixed-Use Building on Highway Frontage

    Commercial and residential units with highway frontage and parking.

    708 Royal Gorge Blvd, Canon City, CO 81212
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    Silver Cliff Inn Business Opportunity
    $869,000
    6,129 SF

    Silver Cliff Inn Business Opportunity

    Established business with living space and motel rooms in Colorado.

    700 Ohio St, Silver Cliff, CO 81252
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    Mixed-Use Building in Silver Cliff
    $349,000
    880 SF

    Mixed-Use Building in Silver Cliff

    Versatile mixed-use property with highway frontage in Silver Cliff, Colorado.

    360 E Main St, Silver Cliff, CO 81252
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    Explore Off-Market Properties in Florence, CO

    Consider similar Off-Market properties in Florence, CO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    Main St

    Main St

    Mixed-use properties • 0.22 Acres
    Value Estimation by Request
    Main St, Florence, CO 81226
    View details
    119 Main St

    119 Main St

    Mixed-use properties • 0.08 Acres
    Value Estimation by Request
    119 Main St, Florence, CO 81226
    View details
    305 Main St

    305 Main St

    Mixed-use properties
    Value Estimation by Request
    305 Main St, Florence, CO 81226
    View details

    Florence, CO Mixed-Use Properties Investment Opportunities Market Analysis

    Explore 13 mixed-use properties for sale in Florence, CO, showcased through 10 active listings on our real estate platform. These investment opportunities span a total of 66,211 square feet of properties for sale, with an estimated market value of $5,105,000.

    Prices for multi use buildings in Florence, CO start at $225,000, averaging $510,500, and reaching up to $750,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you have the most current data.

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