Joplin, MO Mixed-use properties for Rent & Lease

Downtown Joplin Mixed-Use Commercial Space

$6 SF/Yr

7,500 SF

Downtown Joplin Mixed-Use Commercial Space

220 W 2Nd St, Joplin, MO 64801

7500 sq ft mixed-use space with efficient HVAC in Joplin.

7500 sq ft mixed‑use commercial space in downtown Joplin, Missouri.
Excellent accessibility between two one‑way streets for seamless navigation.
Energy‑efficient HVAC systems.
12 ft overhead doors for easy loading/unloading and visibility.
Versatile layouts suitable for various commercial purposes.

Updated: Dec 19, 2025

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Based on your search, we've compiled 24 Potential Opportunities for your consideration. Besides 1 Active listings in Joplin, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 19 Properties for Sales.

Explore Mixed-use properties for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

$16 SF/Yr

41,280 SF

Galleria Shopping Center: Prime Space

Battlefield Road Retail/Office Opportunity

1550 Battlefield Rd, Springfield, MO 65804

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$2,750 / Mo

20,473 SF

Free-Standing Work-Live Office Space

Work-live office space in the 'Roundtree UCD-D' area.

1348 E Cherry St, Springfield, MO 65802

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Contact for pricing

22,864 SF

Santa Fe Square Office Suites

Tulsa Class A Office Space Available

0 Elgin Ave, Tulsa, OK 74120

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$18 SF/Yr

5,500 SF

Post Rock Plaza: Tulsa Executive Suites

South Tulsa Office & Retail Space Available

8211 Regal Ct, Tulsa, OK 74133

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Explore Similar Spaces for Sale in Joplin, MO

Consider Similar Space for Sale. We found 19 Spaces in Nearby Locations matching your search parameters.

$200,000

1,984 SF

Route 66 Commercial Opportunity

Unique commercial space with live-work potential on Route 66.

1209 W 7Th St, Joplin, MO 64801

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Versatile Commercial Building on Route 66

$1,699,000

15,000 SF

Versatile Commercial Building on Route 66

Adaptable commercial building with high visibility and flexible space.

204 East 7Th St, Joplin, MO 64801

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$850,000

42,907 SF

Versatile Mixed-Use Commercial Property

42,907 SF mixed-use property with office and warehouse space.

902 E 4Th St, Joplin, MO 64801

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Pending

$4,100,000

43,053 SF

Prime Commercial Property on Main

4.14-acre commercial property with showroom, apartment, and high visibility.

5014 S Main St, Joplin, MO 64804

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$299,000

5,700 SF

Historic Mixed-Use Building, Joplin

Prime downtown location with retail, commercial, and residential potential.

405 S Main St, Joplin, MO 64801

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$166,000

1.00 Acre

Versatile Land Parcel, Joplin, MO

Adaptable land parcel suitable for various development projects in Joplin.

2830 S Mc Clelland Blvd, Joplin, MO 64804

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$166,000

1.00 Acre

Versatile Land Parcel, Joplin, MO

Adaptable land parcel suitable for various development projects.

2830 S Mc Clelland Blvd, Joplin, MO 64804

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$175,000

0.63 Acres

Joplin Commercial Lot For Sale

Highly visible 0.63 acre commercial lot with development potential.

2202 S Connecticut Ave, Joplin, MO 64804

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Pending

$284,500

2.00 Acres

Versatile Land Parcel, Joplin, MO

Adaptable land parcel suitable for various development projects.

2830 S Mc Clelland Blvd, Joplin, MO 64804

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$190,000

15,000 SF

Historic Mixed-Use Property in Joplin

15,000 sq ft historic property in Joplin's Historic District.

830 Main St, Joplin, MO 64801

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$2,200,000

17,940 SF

Downtown Joplin Mixed-Use Property

Premier mixed-use property with luxury apartments and commercial spaces.

702 S Wall Ave, Joplin, MO 64801

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Joplin Commercial Property with Versatility

$145,000

1,252 SF

Joplin Commercial Property with Versatility

Commercial-zoned property suitable for business, investment, or live/work use.

1317 S Schifferdecker Ave, Joplin, MO 64801

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$500,000

Historic Joplin Landmark For Sale

Redevelopment opportunity in thriving C-1 commercial zone.

2008 S Sergeant Ave, Joplin, MO 64804

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$2,600,000

30,200 SF

Joplin Retail & Warehouse Opportunity

High-Visibility Commercial Property, Missouri

2920 Range Line Rd, Joplin, MO 64804

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$2,200,000

32,750 SF

Joplin Warehouse/Office Space

32,750 SF Mixed-Use Property, Vacant

5571 Main Street Rd, Joplin, MO 64801

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$3,525,000

30,000 SF

Joplin MO Industrial Flex Space

30,000 SF Multi-Tenant Office/Warehouse

4830 32Nd St, Joplin, MO 64804

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Joplin Union Depot: Redevelopment Opportunity

Contact for pricing

22,640 SF

Joplin Union Depot: Redevelopment Opportunity

Historic Train Station, 22,640 sq ft

205 Main St, Joplin, MO 64801

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$397,500

4.00 Acres

Joplin MO Commercial Land & Barn

4-Acre Multi-Use Property, Great Potential

4014 7Th St, Joplin, MO 64801

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$1,800,000

20,185 SF

WestPointe Centre: Joplin Investment

Thriving Mixed-Use Property on Route 66

2207 7Th St, Joplin, MO 64801

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Joplin, MO Mixed-use properties Leasing Opportunities Market Analysis

Explore Mixed-use properties leasing options in Joplin, MO with 20 listings featured on our commercial real estate exchange. The current inventory includes 326,700,000 square feet of properties with an estimated lease value of $6 SF/Yr.

Estimated lease rates for Mixed-use properties in Joplin, MO begin at $6 SF/Yr, with an average of $6 SF/Yr and extend to $6 SF/Yr.

Joplin, MO Mixed-use Properties for Lease

Downtown Joplin Mixed-Use Commercial Space

7500 sq ft mixed-use space with efficient HVAC in Joplin.