Appleton, WI Medical Office Space for Rent & Lease

Updated: Jun 19, 2025

Adaptable Medical Office Space

1600 N CASALOMA Drive, Appleton, WI 54913

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3.11 AC lot

Up to 7,000 square feet available across the property
3,512 square feet currently built out for retail use and modifiable
Three spaces remain available for lease
3.11‑acre commercial property
Constructed in 2007

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Updated: Jun 3

Two-Story Office Building

2600 N Richmond St, Appleton, WI 54911

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862 sqft

17,400 vehicles per day supports high daily visibility and traffic
Two‑story office building built in 1970
Previously used for medical/dental
Easily retrofitted for retail or office
Located along a strong retail corridor with national users nearby

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Based on your search, we've compiled 11 Potential Opportunities for your consideration. Besides 2 Active listings in Appleton, WI, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 5 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Medical Office Space with Highway Frontage

2593 DEVELOPMENT Drive, Green Bay, WI 54311

$1.00 SF/Yr

7.83 AC lot

Commercially zoned medical and office suites offer flexible configurations, including finished Class A space and white-box delivery.

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Two-Suite Office Building with Medical Space

2593 Development Dr, Green Bay, WI 54311

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10,843 sqft

Two office suites available with easy access to WI-172 and County Rd GV, including shell and class A medical space options.

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Office Units Near Library

301 N Broadway St, De Pere, WI 54115

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46,582 sqft

Office space is available for lease with all-inclusive rent terms.

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Updated Office Units Near Library

301 N BROADWAY Street, De Pere, WI 54115

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1.52 AC lot

Commercial office space with flexible layouts, central air, and public water and sewer service.

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Similar Spaces for Sale in Appleton, WI

Consider Similar Space for Sale. We found 5 Spaces matching your search parameters.

Medical-Tenant Strip Mall

1600 N Casaloma Dr, Appleton, WI 54913

$4,250,000

24,510 sqft

The center is occupied primarily by medical tenants and has received upgrades within the last three years.

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Medical-Oriented Strip Center

1600 N CASALOMA Drive, Appleton, WI 54913

$4,250,000

3.11 AC lot

Multi-suite commercial property with BR-1 zoning, public utilities, and upgrades completed within the last 3 years.

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Downtown Commercial Building with Parking

222 S State St, Appleton, WI 54911

$299,900

2,400 sqft

Downtown Appleton commercial building suitable for office or retail use.

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Medical-Focused Shopping Center

1600-1688 N. Casaloma Drive, Appleton, WI 54913

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24,510 sqft

Commercial shopping center with medical occupants, NNN lease structure, available space, and an owner-held backup generator.

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Medical-Focused Strip Center

1616-1688 N Casaloma Dr, Appleton, WI 54913

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Mostly medical tenant occupancy, recent improvements, and available commercial space characterize this strip center.

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Appleton, WI Medical Office Space Lease Rates & Market Statistics

Browse 2 Medical Office Space listings for lease in Appleton, WI on Realmo, a commercial real estate marketplace serving the Appleton area. The current inventory totals 862 square feet of properties.

Appleton accounts for 50% of the 4 medical office space listings currently available across Outagamie County, where nearby markets include Greenville and Kaukauna. Medical Office Space is one of the more limited space types in Appleton, with just 2 listings currently available — a scarcity worth factoring into lease negotiations. Also worth a look for tenants weighing alternatives: Office Units (23 listings) and Office buildings (10 listings) elsewhere in the Appleton market.

Featured Appleton Real Estate Agencies

Realmo connects you with licensed Appleton CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

Think Hallmark Real Estate

2324 W. Spencer St. Appleton, WI 54914

Phone: 19207020122