Appleton, WI Medical Office Space for Rent & Lease

Updated: Jun 19, 2025

Adaptable Medical Office Space

1600 N CASALOMA Drive, Appleton, WI 54913

Contact for pricing

3.11 AC lot

Up to 7,000 square feet available across the property
3,512 square feet currently built out for retail use and modifiable
Three spaces remain available for lease
3.11‑acre commercial property
Constructed in 2007

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Updated: Oct 28

Office Unit with Elevator

229 E Franklin St, Appleton, WI 54911

Contact for pricing

3,686 sqft

3,686‑square‑foot office unit with a bi‑level layout
Existing office and clinic configuration, plus lower‑level office and storage space
Operating elevator provides access between levels
Rear entrance has a staircase and ramp for loading and unloading supplies
Dedicated private parking lot and additional street parking

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Two-Story Office Building

2600 N Richmond St, Appleton, WI 54911

Gross

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3–5 people 1 space 862 sqft Built 1970

Highway access

Well-maintained two-story office building previously used for medical/dental, with strong traffic counts and easy retrofit flexibility.

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3 active listings match your search: Medical Office for lease in Appleton, WI. Based on your search, we've also compiled 9 Potential Opportunities for your consideration: 4 spaces in nearby cities and 5 properties for sale.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Medical Office Space with Highway Frontage

2593 DEVELOPMENT Drive, Green Bay, WI 54311

Triple net (NNN)

$1.00 SF/Yr

4,160–10,843 sqft Built 2006 7.83 acres

Highway access

Commercially zoned medical and office suites offer flexible configurations, including finished Class A space and white-box delivery.

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Office Units Near Library

301 N Broadway St, De Pere, WI 54115

Gross

Contact for pricing

186–310 people 46,582 sqft Built 1988 Multi-tenant

Office space is available for lease with all-inclusive rent terms.

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Two-Suite Office Building with Medical Space

2593 Development Dr, Green Bay, WI 54311

Triple net (NNN) Class A

Contact for pricing

43–72 people 1 space 10,843 sqft

Highway access + Road access

Two office suites available with easy access to WI-172 and County Rd GV, including shell and class A medical space options.

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Updated Office Units Near Library

301 N BROADWAY Street, De Pere, WI 54115

Contact for pricing

1,000–6,000 sqft Built 1988 1.52 acres

Commercial office space with flexible layouts, central air, and public water and sewer service.

200 parking spaces

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Similar Spaces for Sale in Appleton, WI

Consider Similar Space for Sale. We found 5 Spaces matching your search parameters.

Medical-Tenant Strip Mall

1600 N Casaloma Dr, Appleton, WI 54913

$4,250,000

24,510 sqft

The center is occupied primarily by medical tenants and has received upgrades within the last three years.

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Medical Office with Surgery Center

277-279 Altenhofen Dr, Appleton, WI 54913

Contact for pricing

11,023 sqft

Freestanding clinical space includes imaging rooms, surgical recovery areas, and an on-site generator.

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Downtown Commercial Building with Parking

222 S State St, Appleton, WI 54911

$299,900

2,400 sqft

Downtown Appleton commercial building suitable for office or retail use.

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Medical-Focused Shopping Center

1600-1688 N. Casaloma Drive, Appleton, WI 54913

Contact for pricing

24,510 sqft

Commercial shopping center with medical occupants, NNN lease structure, available space, and an owner-held backup generator.

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Medical-Focused Strip Center

1616-1688 N Casaloma Dr, Appleton, WI 54913

Contact for pricing

Mostly medical tenant occupancy, recent improvements, and available commercial space characterize this strip center.

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Appleton, WI Medical Office Space Lease Rates & Market Statistics

Browse 3 Medical Office Space listings for lease in Appleton, WI on Realmo, a commercial real estate marketplace serving the Appleton area. The current inventory totals 4,548 square feet of properties.

Appleton accounts for 60% of the 5 medical office space listings currently available across Outagamie County, where nearby markets include Greenville and Kaukauna. Medical Office Space is one of the more limited space types in Appleton, with just 3 listings currently available — a scarcity worth factoring into lease negotiations. Also worth a look for tenants weighing alternatives: Office Units (25 listings) and Office buildings (8 listings) elsewhere in the Appleton market.

Featured Appleton Real Estate Agencies

Realmo connects you with licensed Appleton CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

EXIT Elite Realty

2711 N Mason St, Suite A Appleton, WI 54914

Phone: (920) 722-1100

www.exitelitewi.com

Expert Real Estate Partners LLC.

613 N Lynndale Drive Appleton, WI 54914

Phone: (920) 903-1600

www.ExpertHomes.com

Coldwell Banker The Real Estate Group

5355 Schroth Lane Appleton, WI 54913

Phone: (800) 236-1550