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    The Colony, TX
    Medical Space

    The Colony, TX Medical Office Space for Lease

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    6 properties
    Retail and Medical Office Suites
    Updated: Oct 29, 2025
    Retail and Medical Office Suites

    5017 S Main St, The Colony, TX 75056

    Contact for pricing
    3,045 sqft
    Retail and office/medical spaces available for lease, including multiple opportunities for different tenant needs
    Two retail opportunities up to 5,900 SF, with one space featuring a patio
    Three medical/office opportunities up to 3,870 SF
    Two buildings can be demised, and the third building is move‑in ready
    Main St frontage rd provides up to 155,000 VPD for high daily traffic exposure
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    Retail and Office/Medical Spaces
    Updated: Oct 29, 2025
    Retail and Office/Medical Spaces

    5017 Main St, The Colony, TX

    Contact for pricing
    4,000 sqft
    High traffic volume: Up to ±55,000 vehicles per day on Main St. frontage road.
    Flexible space options: Retail and Office/Medical spaces available.
    Retail opportunities: Up to ±5,900 SF available, including one with a patio.
    Medical/Office opportunities: Up to ±3,870 SF available.
    Demisable buildings: Two buildings can be divided to suit tenant needs.
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    Retail and Medical Office Suites
    Retail and Medical Office Suites

    5101 Main St, The Colony, TX 75056

    Contact for pricing
    3,870 sqft

    Multiple retail and medical/office suites are available, including a patio option, with access along a high-volume frontage road.

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    Retail and Office/Medical Space
    Retail and Office/Medical Space

    5101 Main St, The Colony, TX

    Contact for pricing
    5,900 sqft

    Retail and office/medical spaces available for lease.

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    Retail and Medical Office Lease
    Retail and Medical Office Lease

    5017 Main St, The Colony, TX 75056

    Contact for pricing
    1,000 sqft

    Mixed retail and medical/office space is available, including two retail options and three medical/office opportunities.

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    Renovated Office Suite with Highway Frontage
    Renovated Office Suite with Highway Frontage

    4815 State Highway 121, Suite 4, The Colony, TX 75056

    Contact for pricing

    Recently renovated office suite with direct frontage along SH 121 and pylon signage, currently leased under an NNN structure.

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    Based on your search, we've compiled 14 Potential Opportunities for your consideration. Besides 6 Active listings in The Colony, TX, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Hospital-Connected Medical Office Building
    Hospital-Connected Medical Office Building

    5575 Warren Pkwy, Frisco, TX 75034

    Contact for pricing
    9,555 sqft

    Large medical office building with convenient hospital connection, ample parking, and covered patient drop-off for healthcare tenants.

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    Baylor Scott & White Connected Medical Office
    Baylor Scott & White Connected Medical Office

    5601 Warren Pkwy, Frisco, TX 75034

    Contact for pricing
    2,724 sqft

    Connected to Baylor Scott & White Medical Center in Frisco with covered patient drop-off and ample surface parking.

    View details
    Plano Office Space For Rent
    Plano Office Space For Rent

    6001 Windhaven Pkwy, Plano, TX

    Contact for pricing
    2,414 sqft

    Office space with high visibility and convenient location in Plano.

    View details
    Two-Story Medical Office Building
    Two-Story Medical Office Building

    7000 W Plano Pkwy, Plano, TX 75093

    Contact for pricing
    4,578 sqft

    Two-story medical office building with multiple entry/exit points and canopy-covered walking paths.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Office Development Land For Lease
    Office Development Land For Lease

    1323 Strawfloor Drive, Jonesboro, AR 72401

    Contact for pricing
    4,000 sqft

    2.43 acres for office development with build-to-suit opportunity.

    View details
    Commercial Land for Long-Term Lease
    Commercial Land for Long-Term Lease

    5538 E Paisano Drive, El Paso, TX 79905

    $5,950/Mo

    Lease a C4-zoned lot with easy interstate access, suited for a range of business and professional uses.

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    Corner Lot on Highway 72
    Corner Lot on Highway 72

    30472 Highway 72, Madison, AL 35756

    $5,000/Mo
    1,875 sqft

    1.7 acre corner lot zoned for commercial, medical, residential.

    View details
    Prime Lexington Outlot Opportunity
    Prime Lexington Outlot Opportunity

    3330 Partner Place, Lexington, KY 40503

    Contact for pricing

    Outlot for ground lease or build-to-suit in South Lexington.

    View details

    The Colony, TX Medical Office Space Market Trends and Statistics

    Explore Medical Office Space leasing options in The Colony, TX with 6 listings featured on our commercial real estate exchange. The current inventory includes 17,815 square feet of properties.
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