New Castle, PA Medical Office Space for Rent & Lease

Updated: Jul 23

Flexible Office Units

1416 Wilmington Rd Unit A, New Castle, PA 16105

$2,200/Mo

0.26 AC lot

C‑1 zoning
0.26‑acre parcel
Layout can function as one facility or be divided into multiple separate units
Supports office, retail, showroom, medical, professional service, and creative workspace uses
1416 Wilmington Rd Unit A, New Castle, PA 16105

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Updated: Sep 5, 2025

Turnkey Medical Office Space

3126 Wilmington Road, New Castle, PA 16105

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6,250 sqft

Fully equipped medical buildout
Specialized HVAC in operatories
Plentiful on‑site parking for patients and staff
Brand‑new roof
6250 SF medical office space

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Based on your search, we've compiled 12 Potential Opportunities for your consideration. Besides 2 Active listings in New Castle, PA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 6 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Medical Office with Exam Rooms

935 Trailwood Dr, Youngstown, OH 44512

Contact for pricing

2,703 sqft

Medical office space with four exam rooms, waiting and reception, plus a full basement for added storage.

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Split-Level Medical Office Space

1515 E Market St, Warren, OH 44483

Contact for pricing

1,800 sqft

Split-level, multi-tenant office suite with abundant windows and immediate medical user availability for this rental.

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Medical Office Space Available

7067 Tiffany Blvd, Youngstown, OH

Contact for pricing

3,650 sqft 6.52 AC lot

Move-in ready medical office space near I-680/US 224 interchange.

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Second-Floor Office Unit

2760 Parkman Rd NW, Warren, OH 44485

Contact for pricing

840 sqft

Suitable for medical or general office use with access to a large rear parking lot.

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Similar Spaces for Sale in New Castle, PA

Consider Similar Space for Sale. We found 6 Spaces matching your search parameters.

Neshannock Township Office Building

3135 Wilmington Rd, New Castle, PA 16105

$875,000

7,000 sqft

Two-story office building near Jameson Hospital with flexible commercial zoning.

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One-Story Mixed-Use Commercial Property

New Castle, PA 16105

$350,000

2.56 AC lot

C-2 zoning and an adaptable layout support a range of commercial applications.

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Two-Story Medical Office Building

3135 Wilmington Rd., New Castle, PA 16105

$875,000

0.60 AC lot

Includes exam rooms, offices, ADA-compliant restrooms, separate utilities, and dedicated HVAC systems.

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Freestanding Medical Office Building

3124 Wilmington Rd, New Castle, PA 16105

Contact for pricing

40,059 sqft 2.63 AC lot

Built in 2011, this 40,000-plus SF medical office sits on 2.63 acres with high daily traffic on Wilmington Rd.

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Outpatient Medical Office Building

3124 WILMINGTON RD, New Castle, PA 16105

Contact for pricing

40,059 sqft

Anchored outpatient facility with built-out suites and in-place UPMC and Allegheny Health Network medical services.

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Medical Suites Available for Sale

2602 Wilmington Rd, New Castle, PA

Contact for pricing

1,152 sqft 4.30 AC lot

Three medical suites available in New Castle, Pennsylvania.

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New Castle, PA Medical Office Space Lease Rates & Market Statistics

Browse 2 Medical Office Space listings for lease in New Castle, PA on Realmo, a commercial real estate marketplace serving the New Castle area. The current inventory totals 6,250 square feet of properties.

Medical Office Space lease rates in New Castle range from $2,200/Mo at the entry level to $2,200/Mo at the top of the market, averaging $2,200/Mo. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings.

New Castle accounts for 100% of the 2 medical office space listings currently available across Lawrence County. Medical Office Space is one of the more limited space types in New Castle, with just 2 listings currently available — a scarcity worth factoring into lease negotiations. Also worth a look for tenants weighing alternatives: Office Units (6 listings) elsewhere in the New Castle market.

New Castle, PA Medical Office Space for Lease

1416 Wilmington Rd Unit A, New Castle, PA 16105

3126 Wilmington Road, New Castle, PA 16105