Manhattan, NY Medical Office Space for Rent & Lease

Updated: Jun 28

Storefront with Full Basement

60-06 Fresh Pond Road, Maspeth N Y, Ny, NY 11378

$4,500/Mo

2,470 sqft 0.04 AC lot

1,235 sq' storefront on Fresh Pond Road
High ceilings with open floor plan and waiting area
Three separate rooms support varied interior layouts
Newly renovated bathroom
Full‑length basement provides storage space

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Updated: Aug 23

Medical Office Space with Two Bathrooms

120-08 131 Street, New York, NY 11420

$4,999/Mo

Approx. 1,140 sq. ft. of commercial space
Multi‑room layout with open, treatment, private office, and hallway areas
Two bathrooms included
Previously configured for lab / medical‑style use
Wet areas, counter runs, and utility‑style features in place

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Medical Office Suite with Exam Rooms

198 Canal Street, New York (, Manhattan, NY 10013

$6,500/Mo

Configured for medical or professional practice with reception, storage, and a private bathroom.

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Medical Office Condo with Exam Rooms

198 Canal St 303, New York, NY 10013

$6,500/Mo

1,847 sqft

Five-room clinical layout with reception, storage, and a private bathroom.

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Medical Office Suite with Exam Rooms

139 Centre St 506, New York, NY 10013

$4,700/Mo

1,023 sqft

Configured for clinical use with sink hookups, a pantry, and a private half bathroom.

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Medical Office Build-to-Spec Space

47-01 Queens Boulevard, New York, NY 11104

$45 SF/Yr

5,181 sqft

Medical office space with ADA elevators and ADA-compliant bathrooms, configured for build-out to practice specifications.

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Boutique Office/Medical Building Near Park

250 West 57th Street, New York, NY 10107

$65 SF/Yr

5,300 sqft

16-story office/medical building near Central Park and Carnegie Hall.

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Lenox Hill Medical Office Space

20 East 68th Street, New York, NY 10065

$6,050/Mo

854 sqft

Professional/medical office for lease in Lenox Hill, Manhattan.

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ADA-Compliant Medical Office Floor

505 W 168th St 4th Floor, New York, NY 10032

$8,950/Mo

Entire medical floor with elevator access and central HVAC, suitable for outpatient and diagnostic-focused practices.

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Midtown Building with Private Lobby

133 West 52nd Street, New York, NY 10019

$65 SF/Yr

54,000 sqft

55,000 sq ft vacant building ideal for healthcare, education.

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Medical Office Suite Above CVS

324 West 125th Street, New York, NY 10027

Contact for pricing

6,780 sqft

Second-floor corner suite with elevator access above CVS and high-capacity electrical service for power-intensive medical uses.

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Ground-Level Office Suite

35 Park Avenue, New York, NY 10010

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400 sqft

Dedicated entrance and a layout suited to medical or dental office use.

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Flexible Office Units

197 3rd Ave, New York, NY 10003

Contact for pricing

3,108 sqft

Office space supports medical, community, daycare, and education uses with flexible division options and an onsite parking garage.

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Medical Office Suite at Transit Hub

185 Greenwich Street, New York, NY 10007

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2,606 sqft

West Concourse Level 2 suite with 41+ feet of frontage along a high-traffic pedestrian corridor in a major downtown retail complex.

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Flexible Office Suite

C13-3370 Prince Street, New York, NY 11354

$2,500/Mo

Flexible office space available for lease in Flushing’s commercial district.

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Class-A Medical Office Building

110 E 60th St, New York, NY 10022

Contact for pricing

58,511 sqft

Prebuilt suites and medical infrastructure support Article 28 users.

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Carnegie Hill Doctor's Office Suite

21 East 93rd Street, New York, NY 10128

$7,500/Mo

Spacious doctor's office in Carnegie Hill townhouse for rent.

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Built-Out Medical Office Space

159 E 30th St, New York, NY 10016

Contact for pricing

1,100 sqft

Second-floor and lower-level availability with a dedicated entrance from Third Avenue.

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ADA-Compliant Medical Office with Elevator

403 E 91st St, New York, NY 10128

Contact for pricing

8,000 sqft

Turn-key medical/office with multiple exam rooms, private offices, and an elevator in place for ADA accessibility.

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Newly Renovated Psychiatric Office

120 West 97th Street, New York, NY 10025

Contact for pricing

3,900 sqft

Newly renovated psychiatric office space available for rent.

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Medical Suite with Doorman Service

4c-115 E 61st St, New York, NY 10065

$9,500/Mo

Medical occupancy is restricted to licensed professionals in a staffed Upper East Side setting.

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Upper East Side Medical Suite

185 East 85th Street, New York, NY 10028

$3,477/Mo

596 sqft

Medical suite for lease on the Upper East Side.

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Medical Suite on Lexington Avenue

137 East 67th Street, New York, NY 10065

$12,000/Mo

1,765 sqft

Renovated medical suite in full-service co-op building for lease.

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White Box Office Suite

57 W 57th St, New York, NY 10019

Contact for pricing

4,498 sqft

Move-in-ready office space with new lighting accommodates professional users, including medical and dental practices.

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Manhattan, NY Medical Office Space Lease Rates & Market Statistics

Browse 69 Medical Office Space listings for lease in Manhattan, NY on Realmo, a commercial real estate marketplace serving the Manhattan area. The current inventory totals 324,486 square feet of properties — an average of ~4,700 SF per listing.

Asking lease rates for Medical Office Space in Manhattan start at $21.86 SF/Yr, average $52.55 SF/Yr, and reach $85.01 SF/Yr at the top of the market. That's a 4x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $52.55 SF/Yr is 62% above the New York state average of $32.48 SF/Yr.

Medical Office Space listings make up 7% of the 999 Office Spaces currently for lease in Manhattan, with asking rates in line with the citywide Office Spaces average. Also worth a look for tenants weighing alternatives: Office Units (582 listings) and Office buildings (351 listings) elsewhere in the Manhattan market.