Centennial, CO Medical Office Space for Rent & Lease

Updated: Nov 21, 2025

Updated Office Medical Building

6979 S Holly Circle, Centennial, CO 80112

$24 SF/Yr

29,788 sqft

Updated 29,755 SF office medical building.
Minutes from I‑25 and C‑470.
Ample parking.
Remodeled 2‑story sky‑lit entrance.
Proactive professional property management with meticulous attention to detail and cleanliness.

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Updated: Oct 4, 2024

Move-in Ready Medical Space

20270 E Smoky Hill Rd, Centennial, CO

$28 SF/Yr

4,400 sqft

Move‑in Ready Medical Space
Features a Lab, MA Work Stations, and X‑Ray Room
Enjoy the convenience of 5 Reserved Parking Spaces
Furniture and Equipment Can Be Included
Multiple On‑Building Signage Options available

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Centennial Med-Tail Space For Rent

5657 S Himalaya St 250, Centennial, CO 80015

$17 SF/Yr

Retail frontage space with open layout and private offices.

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Medical Co-working Space Available

6886 S Yosemite St, Centennial, CO

Contact for pricing

1,560 sqft

Short-term medical co-working space for rent in Centennial, Colorado.

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Centennial Med-Tail Space Available

5657 S Himalaya Street #250, Centennial, CO 80015

$17 SF/Yr

23,789 sqft

Retail frontage space in mixed medical/retail building for rent.

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Centennial Office/Medical Space Available

6650 S Vine St, Centennial, CO 80121

$19 SF/Yr

Office and medical spaces for lease with 24-hour access.

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Centennial Office/Medical Space Available

13275 E Fremont Pl, Centennial, CO 80112

$15 SF/Yr

2,621 sqft

Office and medical space for lease in Centennial, Colorado.

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Based on your search, we've compiled 15 Potential Opportunities for your consideration. Besides 7 Active listings in Centennial, CO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Turnkey Medical Office Suite

9235 Crown Crest Blvd, Parker, CO 80138

$4,923/Mo

1,124 sqft

Fully built-out suite with reception, exam rooms, private offices, and individually controlled HVAC in a healthcare plaza setting.

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Move-In Ready Medical/Office Space

19284 Cottonwood Dr, Parker, CO

$27 SF/Yr

1,993 sqft

Available medical/office space near Parker Adventist and Children’s Hospital.

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Medical Space Available for Rent

10103 Ridgegate Pkwy, Lone Tree, CO

Contact for pricing

2,254 sqft

Medical office space available with on-site amenities.

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Medical and Healthcare Facility Available

10107 Ridgegate Pkwy, Lone Tree, CO

Contact for pricing

5,477 sqft

Medical facility with operating rooms, nursery, and treatment center.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Commercial Land for Long-Term Lease

5538 E Paisano Drive, El Paso, TX 79905

$5,950/Mo

Lease a C4-zoned lot with easy interstate access, suited for a range of business and professional uses.

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Office Development Land For Lease

1323 Strawfloor Drive, Jonesboro, AR 72401

Contact for pricing

4,000 sqft

2.43 acres for office development with build-to-suit opportunity.

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Corner Lot on Highway 72

30472 Highway 72, Madison, AL 35756

$5,000/Mo

1,875 sqft

1.7 acre corner lot zoned for commercial, medical, residential.

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Prime Lexington Outlot Opportunity

3330 Partner Place, Lexington, KY 40503

Contact for pricing

Outlot for ground lease or build-to-suit in South Lexington.

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Centennial, CO Medical Office Space Market Trends and Statistics

Explore Medical Office Space leasing options in Centennial, CO with 7 listings featured on our commercial real estate exchange. The current inventory includes 60,598 square feet of properties with an estimated lease value of $84 SF/Yr.

Estimated lease rates for Medical Office Space in Centennial, CO begin at $15 SF/Yr, with an average of $21 SF/Yr and extend to $28 SF/Yr.