Medical Space

Centennial, CO Medical Office Space for Lease

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Updated Office Medical Building
Updated: Nov 21, 2025
Updated Office Medical Building

6979 S Holly Circle, Centennial, CO 80112

$24 SF/Yr
29,788 sqft
Updated 29,755 SF office medical building.
Minutes from I‑25 and C‑470.
Ample parking.
Remodeled 2‑story sky‑lit entrance.
Proactive professional property management with meticulous attention to detail and cleanliness.
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Medical Office Suite with Patio
Updated: Jul 3
Medical Office Suite with Patio

6650 S Vine St, Centennial, CO 80121

Contact for pricing
2,884 sqft
Move‑in‑ready office suite with a kitchen and multiple offices
In‑place plumbing and compressed air for medical use
Dental/endodontic space with reception, private restroom, multiple offices, and treatment chairs
Existing x‑ray equipment infrastructure in place
Ample parking and on‑site management
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Move-in Ready Medical Office Suite with Patios
Move-in Ready Medical Office Suite with Patios

6650 S Vine St, Centennial, CO 80121

Contact for pricing
1,253 sqft

Move-in ready medical office suite options with in-place utilities for light medical use.

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Centennial Med-Tail Space For Rent
Centennial Med-Tail Space For Rent

5657 S Himalaya St 250, Centennial, CO 80015

$17 SF/Yr
1.92 AC lot

Retail frontage space with open layout and private offices.

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Lower Level Medical Office Suite
Lower Level Medical Office Suite

6650 S Vine St, Centennial, CO 80121

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2,431 sqft

Lower level suite with three private rooms, reception area, patio, and washer/dryer connections.

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Medical Office Suite with Patio
Medical Office Suite with Patio

6650 S Vine St, Centennial, CO 80121

Contact for pricing
2,057 sqft

Move-in-ready dental/medical suite includes reception, private restroom, multiple offices, and treatment chair space.

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Lower Level Medical Office Suite
Lower Level Medical Office Suite

6650 S Vine St, Centennial, CO 80121

Contact for pricing
1,288 sqft

Lower level suite with three offices, a reception/open area, and a private patio with natural light.

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Centennial Med-Tail Space Available
Centennial Med-Tail Space Available

5657 S Himalaya Street #250, Centennial, CO 80015

$17 SF/Yr
23,789 sqft 1.92 AC lot

Retail frontage space in mixed medical/retail building for rent.

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Centennial Office/Medical Space Available
Centennial Office/Medical Space Available

6650 S Vine St, Centennial, CO 80121

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Office and medical spaces for lease with 24-hour access.

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Centennial Office/Medical Space Available
Centennial Office/Medical Space Available

13275 E Fremont Pl, Centennial, CO 80112

Contact for pricing
2,621 sqft

Office and medical space for lease in Centennial, Colorado.

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Based on your search, we've compiled 14 Potential Opportunities for your consideration. Besides 10 Active listings in Centennial, CO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Turn-Key Medical Spa with Treatment Rooms
Turn-Key Medical Spa with Treatment Rooms

7939 East Arapahoe Road, Greenwood Village, CO 80112

Contact for pricing
1,606 sqft

Turn-key medical spa with four dedicated treatment rooms and secure key-code after-hours access.

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First-Floor Office Space
First-Floor Office Space

5775 DTC Blvd, Greenwood Village, CO 80111

Contact for pricing
8,296 sqft

Shell space adjacent to retail, suitable for medical, fitness, showroom, and similar commercial uses.

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Littleton Office Sublease Opportunity
Littleton Office Sublease Opportunity

7261 S Broadway, Littleton, CO

Contact for pricing
1,500 sqft 0.99 AC lot

Office sublease with exam rooms, provider offices, and shared spaces.

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Medical Office Suite with Patient Rooms
Medical Office Suite with Patient Rooms

7261 S Broadway, Littleton, CO 80120

Contact for pricing
1,679 sqft

Medical office suite featuring multiple patient rooms, provider office space, and a large waiting and reception area.

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Centennial, CO Medical Office Space Lease Rates & Market Statistics

Browse 10 Medical Office Space listings for lease in Centennial, CO on Realmo, a commercial real estate marketplace serving the Centennial area. The current inventory totals 66,111 square feet of properties — an average of ~6,600 SF per listing.

Asking lease rates for Medical Office Space in Centennial start at $17 SF/Yr, average $19.33 SF/Yr, and reach $24 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $19.33 SF/Yr is in line with the Colorado state average.

Centennial accounts for 19% of the 53 medical office space listings currently available across Arapahoe County, where nearby markets include Denver and Aurora. Medical Office Space listings make up 28% of the 36 Office Spaces currently for lease in Centennial, with asking rates in line with the citywide Office Spaces average. Tenants comparing options may also consider Office Units (28 listings) and Other office properties (3 listings) elsewhere in the Centennial market.

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