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    Clayton, NC Commercial Real Estate for Lease

    14 results
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    Downtown Clayton Retail Opportunity
    $2,000 / Mo
    1,088 SF

    Downtown Clayton Retail Opportunity

    190 Mill St, Clayton, NC 27520

    Stand-alone building suitable for various community-based businesses.

    • Stand‑alone building in the revitalized Spinning Mill area of Downtown Clayton.
    • Ideal for a coffee shop, bakery, salon, stylist, or other community‑based business.
    • Convenient location just off E Front St.
    • Quick access to both Clayton and Flowers Plantation.
    • Unique and historic building.
    Updated: Feb 12
    View details
    Medical Office Space in Clayton
    $30 SF/Yr
    29,588 SF

    Medical Office Space in Clayton

    166 Springbrook Ave, Clayton, NC 27520

    Class A medical office space available for lease in Clayton.

    • Class A medical office space in a desirable Clayton, NC location.
    • ±6,435 SF suite with flexible occupancy options: immediate availability for ±3,000 SF of shell space and ±3,000 SF occupied by WakeMed (available 9/1/26).
    • Located in an established healthcare corridor with strong medical co‑tenancy.
    • Easy access to Downtown Clayton, Johnston Health, and surrounding residential communities.
    • Conveniently located near US‑70 Business and minutes from I‑40, providing excellent regional connectivity.
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    Retail Space in Flowers Crossroads
    Contact for pricing

    Retail Space in Flowers Crossroads

    Retail space available in mixed-use development, delivery Q4 2024.

    13 District Way, Clayton, NC 27576
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    Retail Space Near Walmart
    Contact for pricing
    70,682 SF

    Retail Space Near Walmart

    Retail space available in 2026, shadow-anchored by Walmart.

    12817 Us-70 W, Clayton, NC 27520
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    Retail Development Opportunity, Clayton, NC
    Contact for pricing

    Retail Development Opportunity, Clayton, NC

    Planned retail development opportunity in Clayton, NC, available Q3 2025.

    Clayton, NC 27527
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    Commercial Land For Lease
    Contact for pricing

    Commercial Land For Lease

    2.45 acres available for lease in Clayton, NC.

    Clayton, NC 27520
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    Clayton Medical Office Building
    $25 SF/Yr
    20,000 SF

    Clayton Medical Office Building

    Prime Clayton location, medical office space available.

    890 Lombard St, Clayton, NC 27520
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    Flowers Crossroads Retail Space
    $34 SF/Yr
    13,910 SF

    Flowers Crossroads Retail Space

    Clayton, NC Strip Center - 2 Spaces Available

    4880 Nc Highway 42, Clayton, NC 27527
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    Clayton Plaza Retail Center
    Contact for pricing
    19,550 SF

    Clayton Plaza Retail Center

    Johnston County, NC Retail Space Available

    12817 Us Highway 70, Clayton, NC 27520
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    Garner Warehouse Space Available
    Contact for pricing
    128,003 SF

    Garner Warehouse Space Available

    Multiple suites, 2,437 - 40,806 SF

    2545 Us-70 Bus, Clayton, NC 27520
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    HealthPark at Forty Two West Office Space
    $28 SF/Yr
    70,000 SF

    HealthPark at Forty Two West Office Space

    Clayton, NC Office Suites - 3,629 - 20,000 SF

    2003 Nc-42, Clayton, NC 27520
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    Clayton Corners Retail Space
    Contact for pricing
    125,708 SF

    Clayton Corners Retail Space

    High-traffic retail space available in Clayton, NC

    11711 Us Highway 70, Clayton, NC 27520
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    Health Park at Forty Two Park West
    $28 SF/Yr
    70,000 SF

    Health Park at Forty Two Park West

    Clayton, NC Medical/Executive Office Suites

    0 Hwy 42, Clayton, NC 27520
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    Prime Clayton Office Land
    Contact for pricing

    Prime Clayton Office Land

    Johnston County Executive Office Space

    2364 Nc Highway 42, Clayton, NC 27520
    View details
    Based on your search, we've compiled 57 Potential Opportunities for your consideration. Besides 14 Active listings in Clayton, NC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 39 Properties for Sales.

    Explore Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Airport Hangar and Office Space
    $27 SF/Yr
    19,000 SF

    Airport Hangar and Office Space

    19,000 SF special purpose building for lease at Johnston County Airport.

    3149-C Swift Creek Rd, Smithfield, NC 27577
    View details
    Johnston County Airport Office Space
    $27 SF/Yr
    19,000 SF

    Johnston County Airport Office Space

    Class A Office Suites near I-95

    3149-C Swift Creek Rd, Smithfield, NC 27577
    View details
    Garner, NC Warehouse Space
    $15 SF/Yr
    45,840 SF

    Garner, NC Warehouse Space

    45,840 SF Warehouse, Flexible Sizes

    2337 Us Highway 70, Garner, NC 27529
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    New Construction Flex/Warehouse Space
    Contact for pricing
    26,702 SF

    New Construction Flex/Warehouse Space

    New construction flex/warehouse space available for lease.

    105 Sigma Dr, Garner, NC 27529
    View details

    Explore Similar Spaces for Sale in Clayton, NC

    Consider Similar Space for Sale. We found 39 Spaces in Nearby Locations matching your search parameters.

    39 Acres in Clayton, NC
    $1,799,000
    39.00 Acres

    39 Acres in Clayton, NC

    39 acres of land for sale in Clayton, North Carolina.

    Washington St, Clayton, NC 27520
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    Commercial Land in Clayton, NC
    $167,000
    0.42 Acres

    Commercial Land in Clayton, NC

    Prime commercial land with B-3 zoning in Clayton, North Carolina.

    141 State Ave, Clayton, NC 27520
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    Commercial Land in Flowers Plantation
    $1,400,000
    2.75 Acres

    Commercial Land in Flowers Plantation

    2.75 acres in Flowers Plantation PUD with commercial approval.

    165 Neuse River Pkwy, Clayton, NC 27527
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    Versatile Commercial Building in Clayton, NC
    $1,500,000
    10,010 SF

    Versatile Commercial Building in Clayton, NC

    9,489 sq ft commercial building on 0.85 acres for sale.

    100 Cunningham Ln, Clayton, NC 27527
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    Clayton, NC - Land For Sale
    $78,999
    0.25 Acres

    Clayton, NC - Land For Sale

    Land for sale in Clayton, North Carolina.

    201 Winding Wood Dr, Clayton, NC 27520
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    Clayton, NC Land For Sale
    $78,999
    0.23 Acres

    Clayton, NC Land For Sale

    Land for sale in Clayton, North Carolina.

    205 Winding Wood Dr, Clayton, NC 27520
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    Commercial Land Near Johnston Hospital
    $2,900,000
    9.71 Acres

    Commercial Land Near Johnston Hospital

    9.71 acre commercial land development opportunity near Johnston Memorial Hospital.

    257 Johnson Estate Rd, Clayton, NC 27520
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    Commercial Lots on Highway 42
    $299,900
    0.62 Acres

    Commercial Lots on Highway 42

    Two vacant commercial lots, cleared and flat, ready to build.

    212 Butternut Ln, Clayton, NC 27520
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    71+ Acres in Rapidly Growing Clayton
    Pending
    $3,500,000
    72.40 Acres

    71+ Acres in Rapidly Growing Clayton

    71+ acres near subdivisions, medical facilities, and downtown Clayton.

    Government Rd, Clayton, NC 27520
    View details
    Dual-Zoned Land in Clayton, NC
    Pending
    $299,000
    4.35 Acres

    Dual-Zoned Land in Clayton, NC

    Unique triangular parcels with commercial and residential zoning, sold as one.

    70 Bus W, Clayton, NC 27520
    View details

    Clayton, NC Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Clayton, NC with 53 listings featured on our commercial real estate exchange. The current inventory includes 8,911,766,160 square feet of properties with an estimated lease value of $168 SF/Yr.

    Estimated lease rates for Commercial real estate in Clayton, NC begin at $22 SF/Yr, with an average of $28 SF/Yr and extend to $34 SF/Yr.
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