649 Main Street, Waltham, MA 02451

Building Details

Year Built

1910

Listing office Lamacchia Realty,Inc.

Listing date Jun 29, 2026

Source Highlandre

Displayed information is deemed reliable but is not guaranteed and should be independently verified.

All listing content including descriptions, pricing, images are the copyrighted material of Lamacchia Realty,Inc.

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Overview

This recently renovated two-story commercial building offers a flexible interior for a range of professional and retail uses. The main level features an open floor plan with expansive storefront windows designed to bring in abundant natural light. Depending on configuration, the space includes multiple private offices or treatment rooms, along with an updated ADA-compliant restroom. A rear service area supports day-to-day operations, and separate rear access adds convenience for staff and deliveries.

The property is located in downtown Waltham on busy Main Street, providing visibility in an active business district. Surrounding uses include established businesses, restaurants, and shops, with access to public transportation and major commuter routes.

For an owner-user, the layout can support an office, medical, or wellness operation, while the storefront-oriented design also accommodates retail, showroom, creative, or other professional uses. For investors, the building is listed for sale with an NNN structure option, and it is described as legal conforming, making it suitable for buyers looking for a versatile downtown asset.

Suggested Use

Pet Grooming Service Tattoo & Piercing Shop Butcher Nursing Home (Bike/Boat/Book/etc) Store Bed & Breakfast Daycare Center (Bike/Boat/Book/etc) Store Arcade & Gaming Center Travel Agency

Zoning and permitted uses should be independently verified with local authorities.

Location Insight

• Map
• Local Demand

City

Waltham

County

Middlesex

State

Massachusetts

Longitude

-71.2363491

Latitude

42.3765869

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FAQs

What type of property is this?

Office building - Renovated two-story building with storefront windows and flexible office/medical layout for owner-users or investors.

Where is this office building located?

The property is located at 649 Main Street Waltham, MA.

What is the asking price?

The asking price for this property is $1,150,000.

What are key features of this property?

This property features: 3,890 SF two‑story commercial building built in 1910 on busy Main Street in downtown Waltham; Recently renovated interior with open floor plan and expansive storefront windows for abundant natural light; Flexible layout with multiple private offices or treatment rooms and a rear service area