San Antonio Medical Office
For Lease
Contact for pricing
5255 Prue Rd, San Antonio, TX
Medical office space available for rent in San Antonio, TX.
Space Size5,702 SF - 17,398 SF
Lot Size1.71 Acres
Days on Market326
Property Features for 5255 Prue Rd
General Information
Standard status
Active
Size
5,702 SF - 17,398 SF
Lot size
1.71 Acres
Property subtype
OFFICE
Lease Type
NNN
Spaces For Lease
at 5255 Prue Rd Contact us5255 Prue Rd AVAILABLE, Now
Floor
Bldg
Size
17,398 SF
Type
OFFICE
Rate
Contact for pricing
Sublease
Yes
- Medical – ambulatory surgery center on-site amenities
- Nearest Airport is San Antonio International Airport, located at 7.2 miles away
Contact us 5255 Prue Rd $16.50/SF/Yr
Floor
1
Size
5,702 SF
Type
OFFICE
Lease Type
NNN
Availability
AVAILABLE, Now
Sublease
No
- New owners painted the exterior, added new monument signage and upgraded the landscaping in late 2019.
Contact us
Listing Agency:
CBRE | San Antonio
(210) 225-1000
Listed By:
Justin Roberts
(210) 269-9808
Source:
Moodyscre
Added: Nov 25, 2025
Changed: Oct 14
Last Checked: Oct 16 at 11:00AM
Displayed information is deemed reliable but is not guaranteed and should be independently verified. All listing content including descriptions, pricing, images are the copyrighted material of CBRE | San Antonio
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Investment Insights
Based on property information with market context.
This property offers medical office space with on-site amenities including an ambulatory surgery center. The building provides a total area of 17398 square feet. The nearest airport is San Antonio International Airport, located 7.2 miles away.
Key Highlights
- Medical – ambulatory surgery center on‑site amenities
- Proximity to San Antonio International Airport (7.2 miles)
Property Analytics
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Current Use
Lease Details
NNN (Triple Net)
Lease Type
$2.48 /SF/Yr
CAM
Location Intelligence
Trade Area within ½ mile
790
Businesses Nearby
Under-served
Demand for This Use
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Business Placement
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Cap Rate, Value Estimation, Potential NOI and more
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Market
Lease Benchmarks for San Antonio, TX
$24.19 /SF/Yr
Avg Asking Price
$8.25–$40 /SF/Yr
Price Range
5,543 SF
Avg Space Size
This space is priced 32% below the average of $24.19 /SF/Yr.
Vacancy Rate% for Office in San Antonio, TX
Frequently Asked Questions
What type of property is this?
Medical Office Space - Medical office space available for rent in San Antonio, TX.
Where is this medical office space located?
The property is located at 5255 Prue Rd San Antonio, TX.
What is the lease rate?
The lease rate is $16.50 SF/Yr.
What are key features of this property?
This property features: Medical – ambulatory surgery center on‑site amenities; Proximity to San Antonio International Airport (7.2 miles)
