Medical Office Space with On-Site
For Lease
Contact for pricing
4100 N Main St, Columbia, SC 29203
Primarily configured for clinical and medical uses, with the flexibility to support traditional office needs and on-site parking.
Property Size1,226 SF
Days on Market359
Property Features for 4100 N Main St
General Information
Standard status
Active
Size
1,226 SF
Property subtype
OFFICE
Lease Type
SF/yr
Additional Details
Space Use
Medical Office
Listing Agency:
Colliers | Columbia
(803) 206-4976
Listed By:
Tommy Johnson, SIOR
(803) 206-4976
Source:
Moodyscre
Added: Aug 7, 2025
Changed: Jul 30
Last Checked: Jul 30 at 3:45PM
Displayed information is deemed reliable but is not guaranteed and should be independently verified. All listing content including descriptions, pricing, images are the copyrighted material of Colliers | Columbia
Investment Insights
Based on property information with market context.
This medical office space is predominantly configured for clinical and medical uses, while still offering flexibility to support traditional office use. The property includes generous on-site parking, which can help simplify daily patient or client access.
Located at 4100 N Main St in Columbia, SC, the space is within about 2 miles of Downtown Columbia and within about 2 miles of Prisma Health Richland Hospital. It is also about 2 miles from the Bull Street District, positioning it conveniently for area activity and services.
The space measures 1,226 SF. The property is currently managed by Colliers.
Located at 4100 N Main St in Columbia, SC, the space is within about 2 miles of Downtown Columbia and within about 2 miles of Prisma Health Richland Hospital. It is also about 2 miles from the Bull Street District, positioning it conveniently for area activity and services.
The space measures 1,226 SF. The property is currently managed by Colliers.
Key Highlights
- 1,226 SF medical office space
- Generous on‑site parking
- Predominantly configured for clinical and medical uses
Property Analytics
Current Use
Lease Details
NNN (Triple Net)
Lease Type
$3.30 /SF/Yr
CAM
Location Intelligence
Trade Area within ½ mile
1,933
Businesses Nearby
Under-served
Demand for This Use
Explore this area
Business Placement
Demographics for 29203, SC
39,449
Population
18,815
Households
2.1
Avg Household Size
38
Median Age
22%
College-Educated
84%
High-School Grad
62.3 sq mi
ZIP Area
633
Density / Sq Mi
$42,371
Median Household Income
$30,228
Median Earnings
$1,041
Median Rent
$121,600
Median Home Value
Market
Lease Benchmarks for Columbia, SC
$22.75 /SF/Yr
Avg Asking Price
$20–$28 /SF/Yr
Price Range
75,142 SF
Avg Space Size
This space is priced 3% below the average of $22.75 /SF/Yr.
Vacancy Rate% for Office in Columbia, SC
Questions? Ask Rey
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Frequently Asked Questions
What type of property is this?
Medical Office Space - Primarily configured for clinical and medical uses, with the flexibility to support traditional office needs and on-site parking.
Where is this medical office space located?
The property is located at 4100 N Main St Columbia, SC.
What is the lease rate?
The lease rate is $22 SF/Yr.
What are key features of this property?
This property features: 1,226 SF medical office space; Generous on‑site parking; Predominantly configured for clinical and medical uses
