301 S MAIN ST, Harrisonburg, VA 22801

This historic 1856-era Italianate-style building, known as the Warren-Sipe House, has been used as an overflow hospital during the Civil War and is currently offered for sale. The property features 10-foot ceilings, ornate fireplaces, and hardwood flooring, providing a classic interior foundation for a range of commercial and hospitality concepts. Based on the existing configuration and finishes, the building may support uses including restaurant, bed and breakfast, retail, professional office, or apartments.

Located in Harrisonburg’s Central Business District and within B-1 zoning, the building is described as being in the heart of Downtown. The listing notes proximity to the Farmers Market, Massanutten Regional Library, and the Children’s Museum, each within one block.

With its historic character and central business location, the Warren-Sipe House is positioned for operators or owners seeking a destination-style property that can accommodate multiple business models under B-1 zoning. The listing also references potential tax benefits tied to state and federal historical tax credits, along with eligibility considerations noted through a Qualified Federal Opportunity Zone and Harrisonburg’s Economic Revitalization Zone. Buyers should review those benefit programs directly to confirm qualification for their specific plans.