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Chillicothe, MO

Chillicothe, MO Commercial Real Estate for Sale

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22 properties

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Turnkey Restaurant with Attached Residence

Updated: Jul 10

Turnkey Restaurant with Attached Residence

425 & 437 Cherry Street, Chillicothe, MO 64601

$475,000

4,848 sqft 0.51 AC lot

3,888 sq ft commercial restaurant with attached residential home and additional customer parking lot
2025 remodel includes new roof, windows, doors, flooring, updated electrical and plumbing, and a brand‑new 10‑ft Hood Mart hood system
Restaurant and south building have updated central A/C, with forced‑air heating; brick construction and flat/asphalt roof
Attached 960 sq ft, two‑story residence built in 1900 offering 3 bedrooms and 2 bathrooms (cosmetic updates needed before occupancy)
Second lot for customer parking accommodates up to 27 vehicles, plus additional street parking

Updated Corner Retail Spa Suite

Updated: Jun 1

Updated Corner Retail Spa Suite

605 Jackson Street, Chillicothe, MO 64601

$125,000

1,464 sqft

Updated commercial building built in 1900
Corner lot with large tinted windows
Includes 2 bathrooms, each with a shower
Plumbing hookups for salon sinks (hookups described as easily removable)
Lots of electrical outlets throughout the building

Multi-Building Industrial and Office

Multi-Building Industrial and Office

1011 Gilbert Street, Chillicothe, MO 64601

$399,900

5.52 AC lot

Three connected buildings on fully fenced acreage with Highway 36 visibility offer office and storage flexibility.

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Turnkey Restaurant with Attached Residence

Turnkey Restaurant with Attached Residence

425 & 437 Cherry Street, Chillicothe, MO 64601

$475,000

4,848 sqft

Turnkey restaurant with indoor and outdoor seating, plus a two-story attached residence and an additional customer parking lot.

Historic Railroad Depot and Freight House

Historic Railroad Depot and Freight House

1 Elm Street, Chillicothe, MO 64601

$149,900

1.06 AC lot

Historic C-1 property in Chillicothe includes a former restaurant depot and adjacent freight house plus an open-air gathering area.

Downtown Restaurant & Mixed-Use Buildings

Downtown Restaurant & Mixed-Use Buildings

607 & 609 Jackson Street, Chillicothe, MO 64601

$325,000

0.14 AC lot

Two downtown commercial buildings operating as a restaurant, with kitchen equipment and additional space above.

Three-Story Mixed-Use Commercial Building

Three-Story Mixed-Use Commercial Building

614 Washington Street, Chillicothe, MO 64601

$155,900

0.10 AC lot

Three-story building with occupied main-level office/retail spaces and two floors of unfinished open areas for redevelopment.

Southtown Shopping Center Retail Center

Southtown Shopping Center Retail Center

402 Washington Street, Chillicothe, MO 64601

$3,200,000

39,504 sqft

Retail shopping center anchored by NAPA Auto Parts and Dollar Tree on a high-traffic Washington Street.

Three-Story Commercial Building

Three-Story Commercial Building

614 Washington St, Chillicothe, MO 64601

$159,900

0.10 AC lot

Main level has seven occupied office/retail spaces; upper floors are unfinished open areas for redevelopment.

Established Bar & Grill Opportunity

Established Bar & Grill Opportunity

21966 Park Street, Chillicothe, MO 64601

$194,900

0.15 AC lot

Well-known bar and grill with covered patio in Chillicothe.

Historic Wabash Railroad Depot

Historic Wabash Railroad Depot

1 Elm Street, Chillicothe, MO 64601

$149,900

3,916 sqft 1.00 AC lot

Iconic 1909 depot and freight house on one acre.

Productive Tillable Land Tract

Productive Tillable Land Tract

LIV 255, Chillicothe, MO 64601

$600,000

40.00 AC lot

A 40-acre tract with 39 tillable acres and named silt loam soils, with gravel road frontage on two sides.

Construction-Ready Industrial Lot

Construction-Ready Industrial Lot

630 Industrial Road, Chillicothe, MO 64601

$125,000

1.20 AC lot

Fully cleared, leveled 1.2-acre parcel in an industrial park, zoned for urban/commercial development.

Multi-Building Flex and Storage Property

Multi-Building Flex and Storage Property

1011 Gilbert Street, Chillicothe, MO 64601

$399,900

5.52 AC lot

Three buildings on fully fenced acreage deliver office space plus secure storage options with strong highway exposure.

Tillable Farmland Tract with Gravel Access

Tillable Farmland Tract with Gravel Access

County Road LIV 538, Chillicothe, MO 64601

$640,000

80.00 AC lot

Nearly all tillable farmland with 0–2% slopes and gravel road frontage on two boundaries for practical access.

Tillable Farmland with River Access

Tillable Farmland with River Access

01 County Road LIV 538, Chillicothe, MO 64601

$920,000

115.00 AC lot

115 M/L acres with high tillability and 0–2% slopes, plus Grand River access for recreation and hunting opportunities.

Street-Side Retail Storefront

Street-Side Retail Storefront

614 Washington Street, Chillicothe, MO 64601

$159,900

For-sale retail storefront on Washington St in Chillicothe, positioned between Jackson St and Webster St for street-level visibility.

Updated Corner Retail Storefront

Updated Corner Retail Storefront

605 Jackson Street, Chillicothe, MO 64601

$125,000

Updated storefront on a corner lot with tinted windows, two showered bathrooms, and an on-site parking lot.

Chillicothe Commercial Property For Sale

Chillicothe Commercial Property For Sale

612 1st Street, Chillicothe, MO 64601

$1,475,000

Commercial property available in Chillicothe, Missouri.

Historic Mixed-Use Opportunity

Historic Mixed-Use Opportunity

709 Washington St, Chillicothe, MO 64601

Contact for pricing

1,866 sqft

Built in 1893, the property includes a commercial building with a full basement and potential upstairs residential finish.

Retail Space in Chillicothe, MO

Retail Space in Chillicothe, MO

720 Washington Street, Chillicothe, MO 64601

Contact for pricing

Retail space available for lease in Chillicothe, Missouri.

Walmart Outlot for Sale

Walmart Outlot for Sale

1000 Graves St, Chillicothe, MO 64601

Contact for pricing

0.75 AC lot

Land parcel offered as a Walmart outlot covering 0.75 acres.

Based on your search, we've compiled Potential Opportunities for your consideration. Besides 22 Active Listings in Chillicothe, MO, we suggest to view alternatives - similar 50 Off-Market properties to explore as potential leads.

Off-Market Properties in Chillicothe, MO

Consider similar Off-Market properties in Chillicothe, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

OFFICE/RESIDENTIAL (MIXED USE)

610 Clay St, Chillicothe, MO 64601-2607

Value Estimation by Request

1,375 sqft 0.08 AC lot

RETAIL STORES (PERSONAL SERVICES)

705 Webster St, Chillicothe, MO 64601-2238

Value Estimation by Request

1,344 sqft 0.01 AC lot

Chillicothe, MO Commercial Real Estate Market Trends and Statistics

Explore 72 commercial real estate for sale in Chillicothe, MO, showcased through 22 active listings on our real estate platform. These investment opportunities span a total of 54,580 square feet of properties for sale, with an estimated market value of $4,424,900.

Sale prices for business properties in Chillicothe, MO start at $125,000, averaging $884,980, and reaching up to $3,200,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Demographics Overview

Population 12K

Population Growth (5Y) +1.4%

Median Household Income $58,804

College Educated 26.0%

High-Yield Neighborhoods for Investment

Identify Chillicothe submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
64601	$585K

Taxes & Financing

Average Loan-to-Value 65.0%

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