Chillicothe, MO Mixed-use properties for sale

Updated: Jul 10

Turnkey Restaurant with Residential Home

425 & 437 Cherry Street, Chillicothe, MO 64601

$475,000

4,848 sqft 0.51 AC lot

3,888 SF turnkey restaurant with indoor and outdoor seating and three half bathrooms
Kitchen includes a brand‑new 10‑foot Hood Mart commercial hood system
Attached 960 SF, two‑story residence built in 1900 with three bedrooms and two bathrooms
2025 remodel: new roof, windows, doors, flooring, and updated electrical and plumbing systems
Exterior central air conditioning unit serving the south building replaced in 2025

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Updated: May 19

Downtown Restaurant Buildings

607 & 609 Jackson Street, Chillicothe, MO 64601

$315,000

0.14 AC lot

Approximately 3,716 square feet of restaurant space
Additional 1,220 square feet above 607 Jackson Street
Includes walk‑in cooler, steam table, prep table, and stove
Tables and booths included with the restaurant layout
Two commercial buildings at 607 & 609 Jackson Street

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Three-Story Mixed-Use Building

614 Washington Street, Chillicothe, MO 64601

$155,900

0.10 AC lot

The building combines occupied office and retail spaces with unfinished upper-level areas suited to redevelopment.

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C2 Mixed-Use Building

701 Third St, Chillicothe, MO 64601

Contact for pricing

572 sqft

Commercially zoned building near Highway 65 with a compact footprint suited to office or live-work use.

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Three-Story Mixed-Use Building

614 Washington St, Chillicothe, MO 64601

$159,900

0.10 AC lot

Occupied main-level office and retail spaces complement unfinished upper-floor areas suited to redevelopment or reconfiguration.

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Mixed-Use Building with Apartments

818 Washington St, Chillicothe, MO 64601

Contact for pricing

9,700 sqft

Main-street commercial property combining office space, warehouse distribution, and separately accessed residential units.

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Based on your search, we've compiled 17 Potential Opportunities for your consideration. Besides 6 Active listings in Chillicothe, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 7 Off-Market properties to explore as potential leads

Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Mixed-Use Building with Apartment

205 N Main St, Gallatin, MO 64640

$94,900

6,300 sqft

Two-level property combines office, retail, storage, warehouse, and residential space with separate entrances.

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Flatiron Mixed-Use Property

1000 Tinsman Avenue, Trenton, MO 64683

$156,900

0.08 AC lot

Renovated main level with restaurant infrastructure, open upper floor, and lower-level storage in a distinctive corner building.

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Mixed-Use Restaurant Property

124 W Grand Street, Gallatin, MO 64640

$145,000

0.07 AC lot

Brick commercial building combines a restaurant-retail level with second-floor residential quarters.

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Flatiron-Style Mixed-Use Building

1000 Tinsman Ave, Trenton, MO 64683

$156,900

Renovated main-level space with restaurant infrastructure and adaptable upper-floor commercial potential.

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Off-Market Properties in Chillicothe, MO

Consider similar Off-Market properties in Chillicothe, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

OFFICE/RESIDENTIAL (MIXED USE)

610 Clay St, Chillicothe, MO 64601-2607

$145,000

Estimated value

1,375 sqft 0.08 AC lot

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OFFICE/RESIDENTIAL (MIXED USE)

818 Washington St, Chillicothe, MO 64601-2232

$275,000

Estimated value

2,900 sqft 0.15 AC lot

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OFFICE/RESIDENTIAL (MIXED USE)

817 Washington St, Chillicothe, MO 64601

$150,000

Estimated value

1,677 sqft 0.10 AC lot

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OFFICE/RESIDENTIAL (MIXED USE)

609 Clay St, Chillicothe, MO 64601-2606

$235,000

Estimated value

5,280 sqft 0.31 AC lot

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OFFICE/RESIDENTIAL (MIXED USE)

602 Jackson St, Chillicothe, MO 64601-2244

$180,000

Estimated value

2,834 sqft 0.06 AC lot

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OFFICE/RESIDENTIAL (MIXED USE)

913 Webster St, Chillicothe, MO 64601-2241

$225,000

Estimated value

4,575 sqft 0.15 AC lot

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OFFICE/RESIDENTIAL (MIXED USE)

610 Jackson St, Chillicothe, MO 64601-2244

$230,000

Estimated value

4,884 sqft 0.06 AC lot

View details

Chillicothe, MO Mixed-Use Properties Market Trends and Statistics

Explore 13 mixed-use properties for sale in Chillicothe, MO, showcased through 6 active listings on our real estate platform. These investment opportunities span a total of 15,120 square feet of properties for sale, with an estimated market value of $1,105,800.

Sale prices for multi use buildings in Chillicothe, MO start at $155,900, averaging $276,450, and reaching up to $475,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

Neighborhood	Average Price
64601	$155.9K

Neighborhood

Average Price

64601

$155.9K