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Turnkey Medical Office Suites
For Lease
$20 SF/Yr

4100 N Main Street, Columbia, SC 29203

Turnkey suites with exam rooms and plumbing, recently renovated common areas, designed for efficient medical operations.

Space SizeContact for details
Property Size3,742 SF
Days on Market65

Property Features for 4100 N Main Street

General Information

Standard status Active
Size 3,742 SF
Property subtype Office

Building Details

Year Built 1987
Year Renovated 2019
Listing Agency: Trinity Partners | Columbia
Listed By: Roger Winn, SIOR · License #136374
Source: Trinity-partners
Added: Jun 2 Changed: Jul 10 Last Checked: Aug 5 at 5:32AM

Displayed information is deemed reliable but is not guaranteed and should be independently verified. All listing content including descriptions, pricing, images are the copyrighted material of Trinity Partners | Columbia

Investment Insights

Based on property information with market context.

Turnkey medical office space available in multiple suite configurations, ranging from 1,226 SF up to 3,742 SF. The offering includes suites built out with clinic-ready components such as exam rooms with plumbing, private offices, restrooms, and dedicated reception and waiting areas. Suite 200 features a reception area, three exam rooms with plumbing, one private office, and a restroom. Suite 201 adds a large reception/waiting area, six exam rooms with plumbing, two private offices, plus IT and storage rooms and a restroom. Suite 101 is approximately 2,484 SF and is available 8/1/26.

The property is located in Columbia’s growing North Main (NOMA) corridor, supporting continued demand for medical and professional services.

This space is a practical fit for healthcare practices that need built-in exam room infrastructure, reception flow, and office support areas without starting from scratch. With major renovations completed in 2019, including a new roof, building façade updates, and common area upgrades, the suites offer a polished, ready-to-operate environment for tenant and operator move-in.

Key Highlights

  • 1987‑built medical office with turnkey suites featuring exam rooms with plumbing
  • Suite 101: ±2,484 SF available 8/1/26
  • Suite 200: ±1,226 SF with reception, 3 exam rooms (with plumbing), 1 private office, and restroom

Property Analytics

Current Use

Tonda Jackson Pediatrician Health Columbia Association / Organization Ivy Health Solutions Medical Clinic Keyoka Smith Physician

Suggested Use

Top Pick Real Estate Agency Electrical Service Big Box & Wholesale Store Accounting Firm Kitchen & Bath Showroom Gym & Fitness Center

Score = modeled unmet demand for each use within ~1 mi (higher = bigger opportunity). Zoning and permitted uses should be independently verified with local authorities.

Lease Details

NNN (Triple Net)
Lease Type
$3.00 /SF/Yr
CAM

Location Intelligence

Trade Area within ½ mile

1,933
Businesses Nearby
Under-served
Demand for This Use

Demographics for 29203, SC

39,449
Population
18,815
Households
2.1
Avg Household Size
38
Median Age
22%
College-Educated
84%
High-School Grad
62.3 sq mi
ZIP Area
633
Density / Sq Mi
$42,371
Median Household Income
$30,228
Median Earnings
$1,041
Median Rent
$121,600
Median Home Value

Market

Lease Benchmarks for Columbia, SC

$22.75 /SF/Yr
Avg Asking Price
$20–$28 /SF/Yr
Price Range
21,321 SF
Avg Space Size

This space is priced 12% below the average of $22.75 /SF/Yr.

Vacancy Rate% for Office in Columbia, SC

18.6% 2020
11.6% 2021
9.7% 2022
7.4% 2023
7.9% 2024
7.9% 2025
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Frequently Asked Questions

What type of property is this?
Medical Office Space - Turnkey suites with exam rooms and plumbing, recently renovated common areas, designed for efficient medical operations.
Where is this medical office space located?
The property is located at 4100 N Main Street Columbia, SC.
What is the lease rate?
The lease rate is $20 SF/Yr.
What are key features of this property?
This property features: 1987‑built medical office with turnkey suites featuring exam rooms with plumbing; Suite 101: ±2,484 SF available 8/1/26; Suite 200: ±1,226 SF with reception, 3 exam rooms (with plumbing), 1 private office, and restroom
More about this property
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