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Medical Building on Hilton Head
For Lease
$17 SF/Yr

4101 Main St Suites E & F, Hilton Head Island, SC 29926

Stand-alone medical building for lease on Hilton Head Island.

Days on Market151

Property Features for 4101 Main St Suites E & F

General Information

Standard status Active
Property subtype Medical & Office Building

Building Details

Year Built 2001
Listing Agency: NAI Carolina Chapter
Listed By: Baker Wilkins · License #31069
Source: Naicarolinacharter
Added: Mar 5 Changed: Jul 6 Last Checked: Aug 2 at 4:55AM

Displayed information is deemed reliable but is not guaranteed and should be independently verified. All listing content including descriptions, pricing, images are the copyrighted material of NAI Carolina Chapter

Investment Insights

Based on property information with market context.

This stand-alone medical office building is located on Main Street on the north end of Hilton Head Island, just off Highway 278. The property offers convenient access to Hilton Head Hospital, the surrounding professional area, and nearby Bluffton. The ground-floor layout features multiple exam rooms, a waiting area, and private offices. Plumbing is in place to support additional exam or treatment rooms. Recently vacated, the building is ready for immediate tenant improvements or occupancy, making it suitable for medical or wellness users seeking a professional island location. The intended use of the property is for medical purposes.

Key Highlights

  • Stand‑alone medical building, ideal for medical or wellness users.
  • Prime location on Main Street, North End of Hilton Head Island, with easy access to Highway 278.
  • Convenient access to Hilton Head Hospital and surrounding professional area.

Property Analytics

Current Use

Isalis (Bike/Boat/Book/etc) Store Party City Party Supply Store Skunk Funk Big Box & Wholesale Store Carl's Trading Co Hat Shop Bushka's Kitchen LLC (Bike/Boat/Book/etc) Store

Suggested Use

Top Pick Building Supply Auto Parts Store Hair Salon Big Box & Wholesale Store Parking Lot & Garage Grocery & Convenience Store

Score = modeled unmet demand for each use within ~1 mi (higher = bigger opportunity). Zoning and permitted uses should be independently verified with local authorities.

Lease Details

NNN (Triple Net)
Lease Type
$2.55 /SF/Yr
CAM

Location Intelligence

Trade Area within ½ mile

445
Businesses Nearby
Under-served
Demand for This Use

Demographics for 29926, SC

24,832
Population
12,642
Households
2
Avg Household Size
56
Median Age
52%
College-Educated
91%
High-School Grad
28.7 sq mi
ZIP Area
865
Density / Sq Mi
$101,573
Median Household Income
$44,019
Median Earnings
$1,448
Median Rent
$600,300
Median Home Value

Market

Vacancy Rate% for Office in South region

14.4% 2019
16.4% 2020
17.3% 2021
18% 2022
18.6% 2023
20.3% 2024
20.2% 2025
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Frequently Asked Questions

What type of property is this?
Medical Office Space - Stand-alone medical building for lease on Hilton Head Island.
Where is this medical office space located?
The property is located at 4101 Main St Suites E & F Hilton Head Island, SC.
What is the lease rate?
The lease rate is $17 SF/Yr.
What are key features of this property?
This property features: Stand‑alone medical building, ideal for medical or wellness users.; Prime location on Main Street, North End of Hilton Head Island, with easy access to Highway 278.; Convenient access to Hilton Head Hospital and surrounding professional area.
More about this property
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