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    Wytheville, VA
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    Wytheville, VA Commercial Real Estate for Sale

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    Richmond, VA Roanoke, VA Fredericksburg, VA
    17 results
    Downtown Wytheville Multi-Purpose Commercial Building
    $399,000
    4,949 SF

    Downtown Wytheville Multi-Purpose Commercial Building

    195 S 1st Street, Wytheville, VA 24382

    Two-story commercial building with income potential in downtown Wytheville.

    • Prime downtown location on a busy corner.
    • Multi‑purpose, two‑story building with existing tenants.
    • Over 2,000 SF of available space on the second floor.
    • Well‑maintained building with a history of successful businesses.
    • Additional income potential from existing tenants.
    Updated: Feb 13
    View details
    Wytheville Land Development Opportunity
    $169,900
    1.85 Acres

    Wytheville Land Development Opportunity

    Peppers Ferry Road lot: 2, Wytheville, VA 24382

    1.847 acres in Wytheville, VA, zoned for diverse development.

    • 1.847 acres of level land with high visibility and direct access to Interstates 81 and 77.
    • Zoned for business, commercial, multifamily, and R‑3 residential use, allowing for diverse development options.
    • Located in Wytheville, VA, the 'Hub of Southwest Virginia', a strategically located and growing community.
    • Utilities (water, sewer, electricity, and natural gas) are readily available at the street.
    • Proximity to Wythe County Progress Park (4.7 miles) and the Wytheville VA Medical Clinic.
    Updated: Apr 16
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    Commercial Lot Near Interstate Exit
    $99,000
    0.91 Acres

    Commercial Lot Near Interstate Exit

    Commercial lot near Interstate 81 exit 70 in Wytheville, VA.

    Holston Road, Wytheville, VA 24382
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    Commercial Lot Near Interstate Exit
    $99,000
    39,630 SF

    Commercial Lot Near Interstate Exit

    Commercial land near I-81 exit with high traffic volume.

    Holston Road, Wytheville, VA 24382
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    Turnkey Storage Operation in Wytheville
    $285,500
    8,900 SF

    Turnkey Storage Operation in Wytheville

    Storage units, garage, and land with income potential.

    2465 Grayson Turnpike, Wytheville, VA 24382
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    Industrial-Zoned Property in Wytheville, VA
    $299,000
    2.58 Acres

    Industrial-Zoned Property in Wytheville, VA

    2.58-acre industrial-zoned property near industrial park in Wytheville, VA.

    N 4th Street, Wytheville, VA 24382
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    Commercial Lot in Wytheville, VA
    $274,000
    1.36 Acres

    Commercial Lot in Wytheville, VA

    Commercial lot with high visibility near I-81 and local amenities.

    1.36 AC N 4th St., Wytheville, VA 24382
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    Wytheville Land with B-2 Zoning
    $55,000
    0.70 Acres

    Wytheville Land with B-2 Zoning

    Vacant lot in Wytheville, VA, zoned B-2.

    W Main Street lot: 2A & 2A1, Wytheville, VA 24382
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    Wytheville Commercial Property with Acreage
    $640,000
    6,000 SF

    Wytheville Commercial Property with Acreage

    Commercial property with building, doublewide, acreage, and mountain views.

    135 Envision Drive, Wytheville, VA 24382
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    Expansive Land Parcel in Wytheville
    $2,950,000
    87.66 Acres

    Expansive Land Parcel in Wytheville

    87+ acre parcel ideal for commercial or residential development.

    Community Blvd lot: 131, Wytheville, VA 24382
    View details
    Historic Office Space in Wytheville
    Contact for pricing

    Historic Office Space in Wytheville

    Furnished, move-in-ready office space in a recognizable historic building.

    150 W Main Street, Wytheville, VA 24382
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    Prime Commercial Land I-81/I-77
    $1,700,000
    3,367 SF

    Prime Commercial Land I-81/I-77

    Unbeatable visibility and location at I-81 and I-77 interchange.

    2484 E Lee Highway, Wytheville, VA 24382
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    Wytheville Commercial Land For Sale
    $2,600,000
    35.00 Acres

    Wytheville Commercial Land For Sale

    35 acres of commercial land near the interstate.

    Stafford Umberger Drive, Wytheville, VA 24382
    View details
    Hotel with Modern Amenities
    $3,500,000
    37,184 SF

    Hotel with Modern Amenities

    Hotel featuring complimentary breakfast, Wi-Fi, and pet-friendly accommodations.

    140 Lithia Rd, Wytheville, VA 24382
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    Retail Space on 1.26 Acres
    $795,000
    6,064 SF

    Retail Space on 1.26 Acres

    6,064 SF retail space in I-81/I-77 Crossroads development.

    190 Lithia Rd, Wytheville, VA 24382
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    17.5 Acres Commercial Land Opportunity
    $640,000
    2,500 SF

    17.5 Acres Commercial Land Opportunity

    17.5 acres with commercial building and mountain views.

    135 Envision Drive, Wytheville, VA 24382
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    Mattress Firm Retail Investment Opportunity
    Contact for pricing
    4,400 SF

    Mattress Firm Retail Investment Opportunity

    Freestanding Mattress Firm at I-81 & I-77 crossroads.

    230 Commonwealth Dr, Wytheville, VA 24382
    View details
    Based on your search, we've compiled Potential Opportunities for your consideration. Besides 17 Active Listings in Wytheville, VA, we suggest to view alternatives - similar 454 Off-Market properties to explore as potential leads.

    Off-Market Properties in Wytheville, VA

    Consider similar Off-Market properties in Wytheville, VA. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    610 Lee Hwy

    610 Lee Hwy

    COMMERCIAL (GENERAL) • 5,394 SF
    Value Estimation by Request
    610 Lee Hwy, Wytheville, VA 24382-1708
    View details
    225 Sandrel Ln

    225 Sandrel Ln

    COMMERCIAL (GENERAL) • 2,032 SF
    Value Estimation by Request
    225 Sandrel Ln, Wytheville, VA 24382-9605
    View details
    110 Spiller St

    110 Spiller St

    COMMERCIAL (GENERAL) • 4,500 SF
    Value Estimation by Request
    110 Spiller St, Wytheville, VA 24382-1952
    View details
    Tazewell St

    Tazewell St

    COMMERCIAL (GENERAL) • 5,552 SF
    Value Estimation by Request
    Tazewell St, Wytheville, VA 24382
    View details
    1340 Main St

    1340 Main St

    COMMERCIAL (GENERAL) • 82,892 SF
    Value Estimation
    $725,000
    1340 Main St, Wytheville, VA 24382-3437
    View details
    1070 Main St

    1070 Main St

    COMMERCIAL (GENERAL) • 18,739 SF
    Value Estimation
    $825,000
    1070 Main St, Wytheville, VA 24382-3308
    View details
    1080 Main St

    1080 Main St

    COMMERCIAL (GENERAL) • 5,672 SF
    Value Estimation
    $820,000
    1080 Main St, Wytheville, VA 24382-3308
    View details

    Wytheville, VA Commercial Real Estate Investment Opportunities Market Analysis

    Explore 471 commercial real estate for sale in Wytheville, VA, showcased through 17 active listings on our real estate platform. These investment opportunities span a total of 108,594 square feet of properties for sale, with an estimated market value of $8,058,500.

    Sale prices for business properties in Wytheville, VA start at $99,000, averaging $1,007,312, and reaching up to $3,500,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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