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    Lee County, IA Commercial Real Estate for Sale

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    Des Moines, IA Dubuque, IA Ankeny, IA
    21 results
    Remodeled Commercial Building on Highway
    $210,000
    0.48 Acres

    Remodeled Commercial Building on Highway

    1219 Avenue H, Fort Madison, IA 52627

    Multi-purpose commercial building with high visibility and versatile layout.

    • High visibility location on Hwy. 61 with commercial zoning and signage.
    • Extensive remodeling since 2021 including new HVAC, water heater, electrical, plumbing, and floor coverings.
    • Versatile layout suitable for office, retail, service, or investment use with multi‑tenant income potential.
    • Two separate entrances and functional layout with office space (3 offices, reception, conference room, kitchen, bath) and retail/showroom area with warehouse/storage.
    • New roof and asphalt parking lot, freshly painted exterior.
    Updated: Feb 19
    View details
    Iconic Downtown Investment Opportunity
    $800,000
    0.39 Acres

    Iconic Downtown Investment Opportunity

    629 Blondeau Street, Keokuk, IA 52632

    Multi-use commercial building with strong income and timeless character.

    • Income‑producing commercial building with 7 leased spaces and diversified revenue streams.
    • Expansive third‑floor event center featuring a restaurant‑style kitchen, bar, and ballroom.
    • Spacious 2,800 sq ft, 4‑bedroom apartment on the second floor for owner occupancy or rental income.
    • Prime downtown location with high visibility and accessibility.
    • Elevator access to all three floors.
    Updated: Jul 17, 2025
    View details
    Refurbished Gymnasium in Solid Brick Building
    $295,000
    0.80 Acres

    Refurbished Gymnasium in Solid Brick Building

    Adaptable commercial property with refurbished gymnasium and large classrooms.

    914 Timea Street, Keokuk, IA 52632
    View details
    Keokuk Land Development Opportunity
    $289,000
    14.47 Acres

    Keokuk Land Development Opportunity

    Prime land parcel with high visibility and development potential.

    Main, Keokuk, IA 52632
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    Commercial Land Near Keokuk Bridge
    Contact for pricing
    0.58 Acres

    Commercial Land Near Keokuk Bridge

    Visible commercial lot near Keokuk bridge, suitable for business.

    2nd Main Street, Keokuk, IA 52632
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    Corner Lots in Keokuk, Iowa
    Contact for pricing
    0.35 Acres

    Corner Lots in Keokuk, Iowa

    Spacious corner lots with utilities in convenient location.

    418 Johnson Street Road, Keokuk, IA 52632
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    Lee County Farmland Opportunity
    Contact for pricing
    532.64 Acres

    Lee County Farmland Opportunity

    532.64 acres of high-quality farmland available for purchase.

    239th Avenue, Montrose, IA 52639
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    Versatile Land Opportunity in Iowa
    $385,000
    15.98 Acres

    Versatile Land Opportunity in Iowa

    Two parcels totaling 15.98 acres suitable for residential or commercial development.

    4601 River bend sub lot 4, Fort Madison, IA 52627
    View details
    Commercial Land in High-Traffic Location
    $149,000

    Commercial Land in High-Traffic Location

    Prime commercial land with excellent visibility for new business venture.

    1795 180th Street, Donnellson, IA 52625
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    Hunting Farm with Income Potential
    $1,006,442
    169.15 Acres

    Hunting Farm with Income Potential

    Classic southeast Iowa hunting farm with income and habitat.

    300th Street, Argyle, IA 52619
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    Iowa Hunting Farm with Income
    $1,006,442
    169.15 Acres

    Iowa Hunting Farm with Income

    Classic southeast Iowa hunting farm near Argyle with CRP income.

    TBD 300th Street, Argyle, IA 52619
    View details
    Lee County Farmland Auction
    Contact for pricing

    Lee County Farmland Auction

    345.03 acres of high-quality farmland in Lee County, Iowa.

    190th St & 130th Ave, Donnellson, IA 52625
    View details
    Commercial Land in Fort Madison, Iowa
    $125,000
    2.62 Acres

    Commercial Land in Fort Madison, Iowa

    2.62-acre commercial land ideal for development in Fort Madison.

    4420 Ave L, Fort Madison, IA 52627
    View details
    Keokuk Land For Sale
    Contact for pricing
    0.10 Acres

    Keokuk Land For Sale

    Flat city lot in the heart of Keokuk.

    1111 Bank Street, Keokuk, IA 52632
    View details
    Former Rehabilitation and Care Facility
    $380,000
    23,051 SF

    Former Rehabilitation and Care Facility

    23,000+ sqft former rehabilitation facility with 46 beds.

    901 State Street, Donnellson, IA 52625
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    Downtown Flex Space Opportunity
    Contact for pricing
    0.11 Acres

    Downtown Flex Space Opportunity

    Versatile building suitable for office, shop, or warehouse use.

    18 S 11Th Street, Keokuk, IA 52632
    View details
    Spacious Mixed-Use Building with Apartments
    $174,900
    8,780 SF

    Spacious Mixed-Use Building with Apartments

    Large mixed-use property featuring retail space and residential apartments.

    820 Avenue G, Fort Madison, IA 52627
    View details
    CVS Pharmacy For Sale
    $3,497,000
    14,820 SF

    CVS Pharmacy For Sale

    NNN leased CVS Pharmacy with approximately 8 years remaining.

    2639 Avenue L, Fort Madison, IA 52627
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    Fort Madison Development Opportunity
    $725,000
    49.02 Acres

    Fort Madison Development Opportunity

    49.02 acre lot for potential development in Fort Madison.

    N Hillview Vil, Fort Madison, IA 52627
    View details
    Keokuk Retail Investment Opportunity
    $799,000
    22,200 SF

    Keokuk Retail Investment Opportunity

    22,200 SF retail property with high visibility and expansion potential.

    3533 Main St, Keokuk, IA 52632
    View details
    Retail Outparcels Available
    Contact for pricing
    3,500 SF

    Retail Outparcels Available

    Two outparcels available for sale, lease, or build-to-suit.

    4810 Avenue O, Fort Madison, IA 52627
    View details
    Based on your search, we've compiled Potential Opportunities for your consideration. Besides 21 Active Listings in Lee County, IA, we suggest to view alternatives - similar 2212 Off-Market properties to explore as potential leads.

    Explore Off-Market Properties in Lee County, IA

    Consider similar Off-Market properties in Lee County, IA. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    613 7th St

    613 7th St

    COMMERCIAL (GENERAL) • 0.03 Acres
    Value Estimation by Request
    613 7th St, Keokuk, IA 52632
    View details
    611 7th St

    611 7th St

    COMMERCIAL (GENERAL) • 0.06 Acres
    Value Estimation by Request
    611 7th St, Keokuk, IA 52632
    View details
    930 15th St

    930 15th St

    MINI-WAREHOUSE, STORAGE • 10,710 SF
    Value Estimation
    $1,305,000
    930 15th St, Fort Madison, IA 52627-4472
    View details

    Lee County, IA Commercial Real Estate Investment Opportunities Market Analysis

    Explore 2233 commercial real estate for sale in Lee County, IA, showcased through 21 active listings on our real estate platform. These investment opportunities span a total of 18,544,363 square feet of properties for sale, with an estimated market value of $9,416,884.

    Sale prices for business properties in Lee County, IA start at $120,000, averaging $724,375, and reaching up to $3,200,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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