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    Lee County, IA Commercial Real Estate for Sale

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    Des Moines, IA Sioux City, IA Cedar Rapids, IA
    23 results
    Iconic Downtown Investment Opportunity
    $800,000
    0.39 Acres
    Iconic Downtown Investment Opportunity

    629 Blondeau Street, Keokuk, IA 52632

    Multi-use commercial building with strong income and timeless character.
    • Income‑producing commercial building with 7 leased spaces and diversified revenue streams.
    • Expansive third‑floor event center featuring a restaurant‑style kitchen, bar, and ballroom.
    • Spacious 2,800 sq ft, 4‑bedroom apartment on the second floor for owner occupancy or rental income.
    • Prime downtown location with high visibility and accessibility.
    • Elevator access to all three floors.
    Updated: Jul 17, 2025
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    Refurbished Gymnasium in Solid Brick Building
    $295,000
    26,000 SF
    Refurbished Gymnasium in Solid Brick Building

    914 Timea Street, Keokuk, IA 52632

    Adaptable commercial property with refurbished gymnasium and large classrooms.
    • Refurbished gymnasium serves as a central hub.
    • Substantial size: over 26,000 sq ft under roof on a 77,000 sq ft lot.
    • Adaptable space suitable for various uses.
    • Features 14 large classrooms and 6+ offices.
    • Solid brick construction.
    Updated: Oct 6, 2025
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    Lee County Timber and Trails
    $935,000
    170.00 Acres
    Lee County Timber and Trails

    170 acre hunting and recreational land near Keokuk, Iowa.

    Carbide Lane, Keokuk, IA 52632

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    Keokuk Land Development Opportunity
    $289,000
    14.47 Acres
    Keokuk Land Development Opportunity

    Prime land parcel with high visibility and development potential.

    Main, Keokuk, IA 52632

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    Commercial Land in High-Traffic Location
    $149,000
    Commercial Land in High-Traffic Location

    Prime commercial land with excellent visibility for new business venture.

    1795 180th Street, Donnellson, IA 52625

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    Former Rehabilitation and Care Facility
    $380,000
    23,051 SF
    Former Rehabilitation and Care Facility

    23,000+ sqft former rehabilitation facility with 46 beds.

    901 State Street, Donnellson, IA 52625

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    Historic Downtown Victorian With Apartment
    $149,000
    3,680 SF
    Historic Downtown Victorian With Apartment

    Victorian commercial building with storefront and 3-bedroom apartment.

    809 G Avenue, Fort Madison, IA 52627

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    Commercial Land in Fort Madison
    $125,000
    2.62 Acres
    Commercial Land in Fort Madison

    2.62-acre commercial land ideal for development in Fort Madison, Iowa.

    4420 Ave L, Fort Madison, IA 52627

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    Vacant Lot in Fort Madison
    $135,000
    1.39 Acres
    Vacant Lot in Fort Madison

    Vacant 1.39 acre lot on the West end of town.

    6119 Reve Court, Fort Madison, IA 52627

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    Spacious Mixed-Use Building with Apartments
    $174,900
    8,780 SF
    Spacious Mixed-Use Building with Apartments

    Large mixed-use property featuring retail space and residential apartments.

    820 Avenue G, Fort Madison, IA 52627

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    Versatile Land Opportunity in Iowa
    $385,000
    15.98 Acres
    Versatile Land Opportunity in Iowa

    Two parcels totaling 15.98 acres suitable for residential or commercial development.

    4601 River bend sub lot 4, Fort Madison, IA 52627

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    Keokuk Land with Hunting Potential
    $89,000
    5.65 Acres
    Keokuk Land with Hunting Potential

    5.65 acres with pond, garage, barn, utilities, and food plots.

    1164 Cramer Lane Place, Keokuk, IA 52632

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    Keokuk Commercial Land For Sale
    Contact for pricing
    0.58 Acres
    Keokuk Commercial Land For Sale

    Visible lot near Keokuk bridge, ideal for small business.

    2nd Main Street, Keokuk, IA 52632

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    Corner Lots in Keokuk, Iowa
    Contact for pricing
    0.35 Acres
    Corner Lots in Keokuk, Iowa

    Spacious corner lots with utilities in convenient location.

    418 Johnson Street Road, Keokuk, IA 52632

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    CVS Pharmacy For Sale
    $3,497,000
    14,820 SF
    CVS Pharmacy For Sale

    NNN leased CVS Pharmacy with approximately 8 years remaining.

    2639 Avenue L, Fort Madison, IA 52627

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    Keokuk Land For Sale
    Contact for pricing
    0.10 Acres
    Keokuk Land For Sale

    Flat city lot in the heart of Keokuk.

    1111 Bank Street, Keokuk, IA 52632

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    Fort Madison Development Opportunity
    $725,000
    49.02 Acres
    Fort Madison Development Opportunity

    49.02 acre lot for potential development in Fort Madison.

    N Hillview Vil, Fort Madison, IA 52627

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    Land in Fort Madison, Iowa
    $95,000
    1.08 Acres
    Land in Fort Madison, Iowa

    Commercial land available for sale in Fort Madison, Iowa.

    213th Street, Fort Madison, IA 52627

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    Keokuk Retail Investment Opportunity
    $799,000
    22,200 SF
    Keokuk Retail Investment Opportunity

    22,200 SF retail property with high visibility and expansion potential.

    3533 Main St, Keokuk, IA 52632

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    Fort Madison Commercial Land Available
    $95,000
    1.18 Acres
    Fort Madison Commercial Land Available

    1.18 acre commercial land for sale in Fort Madison, Iowa.

    213th Street, Fort Madison, IA 52627

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    Downtown Flex Space Opportunity
    Contact for pricing
    0.11 Acres
    Downtown Flex Space Opportunity

    Versatile building suitable for office, shop, or warehouse use.

    18 S 11Th Street, Keokuk, IA 52632

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    Main Street Commercial Space For Sale
    Contact for pricing
    Main Street Commercial Space For Sale

    Commercial property on Main Street, previously a bar/lounge.

    1318 Main Street, Keokuk, IA 52632

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    Retail Outparcels Available
    Contact for pricing
    3,500 SF
    Retail Outparcels Available

    Two outparcels available for sale, lease, or build-to-suit.

    4810 Avenue O, Fort Madison, IA 52627

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    Based on your search, we've compiled Potential Opportunities for your consideration. Besides 23 Active Listings in Lee County, IA, we suggest to view alternatives - similar 49 Off-Market properties to explore as potential leads.

    Off-Market Properties in Lee County, IA

    Consider similar Off-Market properties in Lee County, IA. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    613 7th St
    COMMERCIAL (GENERAL)
    Lot: 0.03 Acres
    Value Estimation by Request

    613 7th St, Keokuk, IA 52632

    View details

    Lee County, IA Commercial Real Estate Investment Opportunities Market Analysis

    Explore 72 commercial real estate for sale in Lee County, IA, showcased through 23 active listings on our real estate platform. These investment opportunities span a total of 98,531 square feet of properties for sale, with an estimated market value of $5,294,900.

    Sale prices for business properties in Lee County, IA start at $149,000, averaging $882,483, and reaching up to $3,497,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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