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    Des Moines County, IA Commercial Real Estate for Sale

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    Des Moines, IA Dubuque, IA Ankeny, IA
    41 results
    Updated Office Building with River Views
    $389,900
    0.16 Acres

    Updated Office Building with River Views

    724 N 3Rd Street, Burlington, IA 52601

    Two-story office building near downtown Burlington with Mississippi River views.

    • Stunning Mississippi River views
    • Conveniently located near downtown with easy access to amenities, dining, and commerce
    • Ample parking for staff and clients
    • Updated office building blending character and modern functionality
    • Suitable for businesses, professional offices, or medical use
    Updated: Feb 6
    View details
    Versatile Commercial Building in Burlington
    $499,000

    Versatile Commercial Building in Burlington

    2601 Madison Avenue, Burlington, IA 52601

    Adaptable 18,000+ SF building on 1.89 acres in Burlington.

    • Over 18,000 SF building on 1.89 acres.
    • Large 12,750 SF former brewing room with 11' x 12' automatic door.
    • Located near Dankwardt and Crapo Parks in South Burlington.
    • Includes approximately 2,500 SF restaurant/lounge space.
    • Features a large outdoor patio area and spacious parking lot.
    Updated: Nov 26, 2025
    View details
    Move-in Ready Office/Retail Space
    Contact for pricing
    1.31 Acres

    Move-in Ready Office/Retail Space

    High-visibility office/retail space near major retailers.

    313 E Agency RD Suite 7, West Burlington, IA 52655
    View details
    Burlington Commercial Building on Large Lot
    $429,000
    1.72 Acres

    Burlington Commercial Building on Large Lot

    4,000 sq ft commercial building on 1.72+/- acre lot.

    3620 Flint Ridge Dr, Burlington, IA 52601
    View details
    Land in Middletown, Iowa
    $89,900
    1.40 Acres

    Land in Middletown, Iowa

    1.4-acre parcel suitable for residential or commercial use.

    155 Main, Middletown, IA 52638
    View details
    Versatile Commercial Property in Burlington
    $550,000
    1.07 Acres

    Versatile Commercial Property in Burlington

    Commercial property with office, shop, and storage space on 1-acre.

    800 Cash Street, Burlington, IA 52601
    View details
    Updated Commercial Property in Burlington
    $164,999
    0.15 Acres

    Updated Commercial Property in Burlington

    Well-maintained commercial property with modern upgrades and ADA accessibility.

    1240 S Main Street, Burlington, IA 52601
    View details
    Historical Building in Downtown Burlington
    $799,000
    15,959 SF

    Historical Building in Downtown Burlington

    Restored 15,959 SF building with restaurant/brewery potential.

    500 Jefferson St, Burlington, IA 52601
    View details
    Historic Commercial Building in Burlington
    $239,500
    0.05 Acres

    Historic Commercial Building in Burlington

    Historic building with modern amenities, ideal for various commercial uses.

    314 N 4Th Street, Burlington, IA 52601
    View details
    Danville, IA Vacant Land
    $677,833
    97.53 Acres

    Danville, IA Vacant Land

    97.53 acres of tillable and recreational land for sale.

    1 165th St, Danville, IA 52623
    View details
    Remodeled Restaurant with Ample Parking
    $680,000
    1.29 Acres

    Remodeled Restaurant with Ample Parking

    Recently remodeled restaurant with long-term tenant and ample parking.

    2806 Mount Pleasant Street, Burlington, IA 52601
    View details
    Burlington Mixed-Use Property For Sale
    $39,900
    2,464 SF

    Burlington Mixed-Use Property For Sale

    Mixed-use property with income potential in a desirable Burlington location.

    1919 S Main, Burlington, IA 52601
    View details
    Burlington Land Near Crapo Park
    $300,000

    Burlington Land Near Crapo Park

    Exceptional building lots in a park-like setting near Crapo Park.

    600 PARKWAY Street, Burlington, IA 52601
    View details
    West Burlington Industrial/Manufacturing Space
    $1,500,000
    7.06 Acres

    West Burlington Industrial/Manufacturing Space

    39,000 sq ft industrial/manufacturing building on 7.06 acres.

    215 N Gear Avenue, West Burlington, IA 52655
    View details
    Burlington Land Ready to Build
    Contact for pricing
    0.19 Acres

    Burlington Land Ready to Build

    Ready to build lot with foundation and sewer in place.

    542 S Central Avenue, Burlington, IA 52601
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    Historic Commercial Building with Modern Amenities
    $264,500
    0.05 Acres

    Historic Commercial Building with Modern Amenities

    Historic building featuring original details and modern updates.

    314 N 4Th Street, Burlington, IA 52601
    View details
    Downtown Burlington Office Condominiums
    $375,000
    3,182 SF

    Downtown Burlington Office Condominiums

    Office condominiums for sale in downtown Burlington, Iowa.

    610 N 4th St, Burlington, IA 52601
    View details
    Truck Service Facility For Sale
    $4,500,000
    65,505 SF

    Truck Service Facility For Sale

    Turnkey truck service facility with high visibility and renovated office.

    906 Broadway Street, West Burlington, IA 52655
    View details
    Land in Middletown, Iowa
    Contact for pricing

    Land in Middletown, Iowa

    Commercial land with utilities available in Middletown, Iowa.

    200 South, Middletown, IA 52638-1
    View details
    Redevelopment Opportunity in Burlington, Iowa
    $400,000
    48,000 SF

    Redevelopment Opportunity in Burlington, Iowa

    48,000 SF mixed-use building for sale, redevelopment opportunity.

    903 Oak St, Burlington, IA 52601
    View details
    17-Door Cross-Dock on 2.65 Acres
    Contact for pricing

    17-Door Cross-Dock on 2.65 Acres

    17-door cross-dock terminal on a 2.65-acre lot.

    1134 Broadway St, West Burlington, IA 52655
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    Historic Downtown Building For Sale
    $75,000
    2,262 SF

    Historic Downtown Building For Sale

    2,262 SF historic building in downtown area available for purchase.

    513 Jefferson St, Burlington, IA 52601
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    Large Industrial Building with Rail
    Contact for pricing
    394,886 SF

    Large Industrial Building with Rail

    Spacious industrial building with excellent utilities and rail access.

    510 E Agency Rd, West Burlington, IA
    View details
    Updated Office Building with Views
    $389,900
    4,892 SF

    Updated Office Building with Views

    Two-story office building near downtown with Mississippi River views.

    724 N. 3rd. St., Burlington, IA 52601
    View details

    Des Moines County, IA Commercial Real Estate Investment Opportunities Market Analysis

    Explore 2341 commercial real estate for sale in Des Moines County, IA, showcased through 41 active listings on our real estate platform. These investment opportunities span a total of 4,896,667 square feet of properties for sale, with an estimated market value of $6,058,032.

    Sale prices for business properties in Des Moines County, IA start at $59,900, averaging $432,716, and reaching up to $1,500,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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