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    Osprey, FL Commercial Real Estate for Sale

    29 results
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    Turnkey Restaurant Opportunity in Osprey
    $1,600,000
    3,871 SF

    Turnkey Restaurant Opportunity in Osprey

    3983 Destination Dr, Osprey, FL 34229

    Two-story, fully built-out restaurant with seating for 150 guests.

    • Turnkey, fully built‑out 3,871 SF restaurant space with seating for ~150 guests plus outdoor dining.
    • Prime location in a rapidly growing, high‑traffic area along US‑41 with excellent signage visibility.
    • Revenue‑ready layout with spacious dining room and centralized bar.
    • Second floor with elevator access, balcony, additional kitchen space, storage, walk‑in cooler, and dining area with coffee bar.
    • Strong ROI potential due to flexible CG zoning and 200+ new adjacent luxury residential units.
    Updated: Jan 23
    View details
    OSPREY, FL Retail Space
    $700,000
    1,741 SF

    OSPREY, FL Retail Space

    3983 Destination Dr, Osprey, FL 34229

    Premier commercial space with flexible layout and high visibility.

    • Revenue‑ready layout featuring a kitchen, walk‑in cooler, dining area with coffee bar, and balcony perfect for a restaurant or event space.
    • Prime location in Bay Street Village and Towncenter offering high visibility along US‑41 and strong foot traffic.
    • Flexible CG zoning allows for a variety of commercial uses.
    • Restaurant equipment included in the sale; furniture is available.
    • Excellent signage visibility on a prominent entrance tower.
    Updated: Dec 11, 2025
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    Osprey Mixed-Use Development Opportunity
    $1,400,000
    1 SF

    Osprey Mixed-Use Development Opportunity

    2.5-acre lot on Tamiami Trail, ideal for mixed-use development.

    2099 S Tamiami Trl N, Osprey, FL 34229
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    Turnkey Restaurant Space in Osprey
    $1,050,000
    2,030 SF

    Turnkey Restaurant Space in Osprey

    Restaurant space with indoor and outdoor seating in high-traffic area.

    3983 Destination Dr, Osprey, FL 34229
    View details
    Osprey Land on Tamiami Trail
    $1,400,000
    2.51 Acres

    Osprey Land on Tamiami Trail

    2.51 acre lot in Osprey, Florida, on South Tamiami Trail.

    2099 S Tamiami Trl, Osprey, FL 34229
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    Prime Retail Location on Trail
    $2,950,000
    14 SF

    Prime Retail Location on Trail

    Commercial land for sale in a prime retail location.

    1301 S Tamiami Trl, Osprey, FL 34229
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    Commercial Land For Sale
    $374,900

    Commercial Land For Sale

    Commercial land available for sale.

    436 S Tamiami Trl, Osprey, FL 34229
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    Osprey Specialty Property For Sale
    $159,900

    Osprey Specialty Property For Sale

    Specialty property available for purchase in Osprey, Florida.

    170 Edgewood Dr, Osprey, FL 34229
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    Boat Dockominium with Extensive Amenities
    $98,000

    Boat Dockominium with Extensive Amenities

    High-end boat dockominium with comprehensive services and amenities.

    570 Blackburn Point Rd, Osprey, FL 34229
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    Turnkey Restaurant on High-Traffic US-41
    Contact for pricing

    Turnkey Restaurant on High-Traffic US-41

    Fully built-out restaurant with equipment, seating, and ample parking.

    66 Tamiami Trl, Osprey, FL 34229
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    Freestanding Building on Tamiami Trail
    Contact for pricing

    Freestanding Building on Tamiami Trail

    Highly visible 525 SF building on US-41 in Osprey, FL.

    240 N Tamiami Trl, Osprey, FL 34229
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    Osprey Gulf Front Development Opportunity
    Contact for pricing
    2,957 SF

    Osprey Gulf Front Development Opportunity

    Prime 5.498-acre site for hotel, retail, and commercial development.

    135 Bayview Dr, Osprey, FL 34229
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    Upscale Waterfront Retail-Office Condominium
    $439,000
    1,050 SF

    Upscale Waterfront Retail-Office Condominium

    Turn-key retail-office condominium in a growing waterfront community.

    3976 Destination Dr, Osprey, FL 34229
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    Osprey Land with US-41 Frontage
    Contact for pricing

    Osprey Land with US-41 Frontage

    1.74 acre vacant site with direct US-41 frontage.

    509 S Tamiami Trl, Osprey, FL 34229
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    Osprey Commercial Land Opportunity
    Contact for pricing

    Osprey Commercial Land Opportunity

    10-acre commercial land with existing office building in Osprey.

    505 Luminary Blvd, Osprey, FL 34229
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    Bay Street Commercial Space Available
    $700,000
    1,741 SF

    Bay Street Commercial Space Available

    Premier commercial space in a vibrant, high-traffic location.

    3983 Destination Dr, Osprey, FL 34229
    View details
    Turnkey Restaurant Space in Osprey
    $1,050,000
    2,030 SF

    Turnkey Restaurant Space in Osprey

    Ready-to-operate restaurant space in a high-traffic area.

    3983 Destination Dr, Osprey, FL 34229
    View details
    Osprey Land on Tamiami Trail
    $1,400,000

    Osprey Land on Tamiami Trail

    2.5 acre lot zoned OPI on South Tamiami Trail.

    2099 S Tamiami Trl N, Osprey, FL 34229
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    Osprey Development Site on Tamiami
    Contact for pricing
    182,100 SF

    Osprey Development Site on Tamiami

    4-acre cleared development site with high visibility and traffic.

    2301 S Tamiami Trl, Osprey, FL 34229
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    Osprey Land on Tamiami Trail
    $1,400,000

    Osprey Land on Tamiami Trail

    2.51-acre lot zoned OPI, suitable for office/retail/medical.

    2099 S Tamiami Trl, Osprey, FL 34229
    View details
    Restaurant-Ready Space in Osprey
    $1,600,000
    3,871 SF

    Restaurant-Ready Space in Osprey

    Turnkey restaurant opportunity in a vibrant, high-growth location.

    3983 Destination Dr, Osprey, FL 34229
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    Move-In Ready Osprey Office Space
    Contact for pricing
    2,314 SF

    Move-In Ready Osprey Office Space

    Fully furnished office space in Baystreet Village, Osprey.

    3976 Destination Dr, Osprey, FL 34229
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    Osprey Office Building & Land
    $7,499,000
    4,000 SF

    Osprey Office Building & Land

    10-Acre Commercial Property, Prime Location

    505 Luminary Blvd, Osprey, FL 34229
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    Osprey Office Condo For Sale
    Contact for pricing
    1,272 SF

    Osprey Office Condo For Sale

    Sophisticated office condo in a prime Osprey location.

    436 S Tamiami Trl, Osprey, FL 34229
    View details

    Osprey, FL Commercial Real Estate Investment Opportunities Market Analysis

    Explore 29 commercial real estate for sale in Osprey, FL, showcased through 29 active listings on our real estate platform. These investment opportunities span a total of 703,058 square feet of properties for sale, with an estimated market value of $13,649,000.

    Sale prices for business properties in Osprey, FL start at $700,000, averaging $2,274,833, and reaching up to $7,499,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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