Medina County, TX Commercial Real Estate for Lease

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Standalone Medical Office Suite
Updated: Jun 1
Standalone Medical Office Suite

200 West College Avenue, Devine, TX 78016

Contact for pricing
1,800 sqft
1,800 SF standalone medical office building available for sale or lease.
Previously used as a dialysis clinic and features a medical‑grade layout.
Includes exam rooms, clinical sinks, cabinetry, and a reception area.
Move‑in ready space suitable for a medical practice or other professional office use.
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Commercial Property for Lease/Sale
Updated: May 14
Commercial Property for Lease/Sale

161 County Road 777, Devine, TX 78016

Contact for pricing
Year Built: 1986
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Retail Space Near Walmart
Retail Space Near Walmart

Menefee St, Hondo, TX

$16 SF/Yr
5,000 sqft

Retail space available in Walmart shadow-anchored development.

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Retail Center on Highway 90
Retail Center on Highway 90

Hwy 90 & fm 471, Castroville, TX 78009

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New retail center ideal for drive-thru businesses on Highway 90.

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Outparcel Build-to-Suit Opportunity
Outparcel Build-to-Suit Opportunity

1151 US-90, Castroville, TX 78009

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Commercial land available for lease, build-to-suit.

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Based on your search, we've compiled 54 Potential Opportunities for your consideration. Besides 5 Active listings in Medina County, TX, we suggest exploring alternatives. Similar 49 Properties for Sales.

Similar Spaces for Sale in Medina County, TX

Consider Similar Space for Sale. We found 49 Spaces matching your search parameters.

Historic Retail-Office Building with Parking
Historic Retail-Office Building with Parking

1708 AVE M, Hondo, TX 78861

$249,000
2,320 sqft

Historic storefront building with versatile interior spaces, upgraded restrooms, and convenient street and rear parking.

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Historic Retail Building with Warehouse
Historic Retail Building with Warehouse

1118 18th St, Hondo, TX 78861

$342,720
3,264 sqft

Historic storefront includes a spacious front sales area, rear warehouse, two bathrooms, and a rear exit to an alley.

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Unrestricted Land Tract
Unrestricted Land Tract

3124 HWY 90 E, Castroville, TX 78009

$2,700,000
1,960 sqft 5.08 AC lot

Unrestricted tract with 5.084 acres, outside city limits, with a manufactured home slated for removal.

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Warehouse with Refrigerated Storage
Warehouse with Refrigerated Storage

568 Carter, Hondo, TX 78861

$1,500,000
23,050 sqft 4.00 AC lot

Perimeter-fenced multi-building facility includes insulated refrigerated warehouse space and a separate office building.

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Unrestricted Land in Castroville, TX
Unrestricted Land in Castroville, TX

3100 HWY 90 E, Castroville, TX 78009

$2,700,000
2,432 sqft 5.08 AC lot

5.077 acres of unrestricted land west of San Antonio.

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Clearwater Express Car Wash
Clearwater Express Car Wash

101 19th St, Hondo, TX 78861

$4,425,843
4,954 sqft

Car wash property for sale in Hondo, Texas.

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Unrestricted Residential Land
Unrestricted Residential Land

17272 Fm 463, Natalia, TX 78059

$235,000
1,512 sqft 6.08 AC lot

Unrestricted, residential-zoned land with no HOA restrictions in Natalia, Texas, offering space to build your custom home.

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Self Storage Facility with Multiple Buildings
Self Storage Facility with Multiple Buildings

332 Private Road 6632, Devine, TX

$175,000
36,729,792 sqft

For sale self storage property featuring seven storage buildings plus trailers and storage sheds with electricity and water.

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Ag-Exempt Ranch Parcel with Hill Views
Ag-Exempt Ranch Parcel with Hill Views

916 Private Road 2532, Mico, TX 78056

$2,744,000
840 sqft

Ag-exempt 196-acre ranch with an 8' game-fenced perimeter, two mobile homes, and a 2,000 sq ft metal building on slab.

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Office Space with Highway Frontage
Office Space with Highway Frontage

2806 Us Highway 90, Hondo, TX 78861

$225,000
1,232 sqft 0.30 AC lot

0.3-acre site with a fully redone manufactured home office, new drive, and parking with visibility from US Highway 90.

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Unrestricted Development Land Outside City Limits
Unrestricted Development Land Outside City Limits

1140 County Road 6710, Natalia, TX 78059

$150,000
400 sqft 3.00 AC lot

Leveled, cleared land with a dry pond and street-available utilities, offered outside city limits.

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Secluded Equestrian Ranch Acreage
Secluded Equestrian Ranch Acreage

4317 Cr 251, Hondo, TX 78861

$995,000
1,969 sqft

Secluded ranch acreage with a 2023-built home and a fenced 1-acre horse pasture, accessed via paved county road.

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Rock Home Equestrian Ranch
Rock Home Equestrian Ranch

4125 County Road 251, Hondo, TX 78861

$1,250,000
51.00 AC lot

Equestrian ranch with a custom rock main house, guest house, pole barn, and fenced, cross-fenced grounds.

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221 Acre Medina County Ranch
221 Acre Medina County Ranch

D Hanis, TX 78850

$1,327,992
221.33 AC lot

Versatile South Texas ranch with hunting habitat and native pastureland.

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Land Tract with Cattle Pens
Land Tract with Cattle Pens

County Road 741, Yancey, TX 78886

$44,000
38,943 sqft 0.89 AC lot

Rural land with paved road frontage and two enclosed cattle pens, offering space to build or support livestock use.

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Unrestricted Land with Mobile Park
Unrestricted Land with Mobile Park

135 COUNTY RD 480, Castroville, TX 78009

$1,500,000
13.58 AC lot

Unrestricted acreage with an existing mobile home park featuring 10 occupied rental lots and undeveloped land for expansion.

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Commercial Corner Lot
Commercial Corner Lot

0000 22nd St, Hondo, TX 78861

$365,000
0.83 AC lot

Corner lot offering high visibility and for-sale ownership, with surrounding retail and medical users nearby.

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Recreational Ranch Acreage with Hilltop Views
Recreational Ranch Acreage with Hilltop Views

5394 FM 2200 Rd W, Devine, TX 78016

$799,000
110.50 AC lot

Ranch acreage with rolling terrain, two hilltops, and on-site well and pond for recreation and livestock needs.

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Unrestricted Industrial Land Tract
Unrestricted Industrial Land Tract

180 County Road 777, Devine, TX 78016

$1,195,000
38.00 AC lot

Unrestricted 38-acre tract near the IH-35 on-ramp with an existing water well, septics, and utility services nearby.

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Medina County, TX Commercial real estate Market Trends and Statistics

Explore Commercial real estate leasing options in Medina County, TX with 5 listings featured on our commercial real estate exchange. The current inventory includes 5,000 square feet of properties with an estimated lease value of $16 SF/Yr.

Estimated lease rates for Commercial real estate in Medina County, TX average $16 SF/Yr.
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