Effingham County, IL Commercial real estate for Rent & Lease

Updated: May 26

Downtown Office Suite for Lease

104 W Washington Ave, Effingham, IL 62401

$1,600/Mo

2,050 sqft

2050 SF office space available in downtown Effingham
Layout includes three private offices and a large open room
Includes conference area, breakroom, and two restrooms
Suite is available for lease with owner flexibility

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Updated: Sep 9, 2025

Office-Warehouse Flex Space

309 Professional Park Avenue, Effingham, IL 62401

$4,000/Mo

5,814 sqft

5,814 total square feet
3,330‑square‑foot office area with reception and restrooms
2,484‑square‑foot warehouse with 16' ceiling
14' overhead door
13x20 office inside the warehouse

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Junior Anchor Retail Space with Pylon

1000-1006 N Keller Dr, Effingham, IL 62401

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10,069 sqft

Available junior anchor space in a retail center shadowed by Hobby Lobby, with pylon signage and direct access off I-57.

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Medical Office Space with Treatment Rooms

401 N Keller Dr, Effingham, IL 62401

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2,000 sqft

Former chiropractic office offers an open reception area, high ceilings, and six treatment rooms with storage and back work space.

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Large-Scale Manufacturing Facility

515 W Main St, Teutopolis, IL 62467

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90,000 sqft

Large industrial facility configured for manufacturing, processing, or bulk storage with truck-accessible site and yard use.

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Divisible Commercial Land Outlot

201 Walk Ave, Effingham, IL 62401

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2.00 AC lot

Divisible outlot on US Route 45 with strong passing traffic and nearby I-70/I-57 access.

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Prime Commercial Outlot Opportunity

201 Walk Ave, Effingham, IL 62401

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2.00 AC lot

Available 2-acre outlot near Rural King and major routes.

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Based on your search, we've compiled 23 Potential Opportunities for your consideration. Besides 7 Active listings in Effingham County, IL, we suggest exploring alternatives. Similar 16 Properties for Sales.

Similar Spaces for Sale in Effingham County, IL

Consider Similar Space for Sale. We found 16 Spaces matching your search parameters.

Auto Repair Facility with Lifts

2300 Hoffman Drive, Effingham, IL 62401

$975,000

7,080 sqft 2.52 AC lot

Turnkey auto repair business and real estate with seven lifts, multiple workstations, and a fenced yard on 2.52 acres.

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Single-Story Office Building

313 Professional Park Avenue, Effingham, IL 62401

$513,000

5,298 sqft 2.80 AC lot

Open-plan office property with private offices, training room, kitchen, and four restrooms.

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Medical Condo Office Units

401 North Keller Drive, Effingham, IL 62401

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6,000 sqft

Two middle condo suites totaling 6,000 SF, with one vacant and ready for occupancy in an established healthcare-anchored center.

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Multi-Tenant Retail Plaza

401 S Banker Street, Effingham, IL 62401

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10,401 sqft 1.08 AC lot

Four Points Plaza is a multi-tenant retail center with 100% occupancy and strong visibility at a signalized intersection.

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Senior Housing Retirement Facility

1234 North Main Street, Effingham, IL 62401

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19,500 sqft

For sale senior housing facility with healthcare-oriented use, listed at approximately 19,500 square feet.

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Bar & Grill with Private Room

112 W. Adams Ave, Altamont, IL 62411

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9,900 sqft

Established bar and grill with a private event room and an upstairs apartment currently rented.

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Bar and Grill Restaurant

112 W Adams Avenue, Altamont, IL 62411

$679,000

Bar and grill with a rented upstairs apartment and a private room for events.

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Commercial Land with On/Off Access

809 N Keller Drive, Effingham, IL 62401

$645,900

Commercially zoned 2-lot parcel with existing structure on a high-visibility site just off an I-57/I-70 exit.

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High-Traffic Drive-Thru Investment Opportunity

406 N Keller Dr, Effingham, IL 62401

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600 sqft

NNN leased drive-thru property with high visibility on a highway.

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Large Industrial Manufacturing Facility

515 W Main St, Teutopolis, IL 62467

Contact for pricing

90,000 sqft

Large-scale industrial facility designed for manufacturing, processing, or bulk storage with truck access and yard use.

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Industrial Facility with Yard Access

515 W Main St, Teutopolis, IL 62467

Contact for pricing

90,000 sqft

Large industrial facility designed for manufacturing, processing, or bulk storage with truck access and yard use.

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Medical/Office Suite with X-Ray Room

511 W Virginia Ave, Effingham, IL 62401

$219,000

Suite includes seven private offices, reception, customer restroom, x-ray room, and break area with storage.

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Interstate-Adjacent Commercial Land

101 Outer Belt W, Effingham, IL 62401

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4.50 AC lot

Commercial land near I-70 offers high-volume interstate access and proximity to multiple interstate exits.

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Cleared Development Land Parcel

15205 N Siemer Road, Effingham, IL 62401

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2.16 AC lot

Over 2 acres of land with select tree and brush clearing, offering flexibility for future development in Effingham.

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Commercial Land Outlot Near Major Interchange

201 Walk Ave, Effingham, IL 62401

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2.00 AC lot

Divisible outlot positioned near the I-70/I-57 split with heavy daily traffic nearby.

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Commercial Outlot Near Rural King

201 Walk Ave, Effingham, IL 62401

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2.00 AC lot

2 AC divisible outlot near Rural King on US Route 45.

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