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Santa Cruz County, CA Commercial Real Estate for Lease

118 results
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Downtown Santa Cruz Office Building
$4,000 / Mo
2,060 SF

Downtown Santa Cruz Office Building

129 Water St, Santa Cruz, CA 95060

Freestanding commercial office building in the heart of downtown Santa Cruz.

  • Freestanding commercial office building in the heart of downtown Santa Cruz.
  • Move‑in ready condition for owner‑occupant or tenant.
  • 10 offices, 2 conference rooms, and a large reception area.
  • Modern infrastructure with controlled door access, security cameras, and prominent street signage.
  • 4 on‑site parking spaces and excellent walkability to downtown amenities.
Updated: Oct 6, 2025
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Commercial Space in Santa Cruz
$2,495 / Mo
4,000 SF

Commercial Space in Santa Cruz

2017 Pacific Ave, Santa Cruz, CA 95060

Retail space for lease in Santa Cruz, California.

  • Unique location
  • Good size for most businesses
  • Recently painted inside and out
  • Big windows
  • New flooring to be installed
Updated: Nov 13, 2025
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Retail/Office Space in Santa Cruz
$2,500 / Mo
3,135 SF

Retail/Office Space in Santa Cruz

3135 SF retail or office space available for rent.

Cooper St, Santa Cruz, CA 95060
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Santa Cruz Warehouse - 13,200 SF
$15 SF/Yr
13,200 SF

Santa Cruz Warehouse - 13,200 SF

Large Santa Cruz warehouse, ample parking.

2450 17Th Ave, Santa Cruz, CA 95062
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Westgate Drive Executive Office/Warehouse
$11 SF/Yr
18,600 SF

Westgate Drive Executive Office/Warehouse

18,600 SF Office/Warehouse in Watsonville, CA

180 Westgate Dr, Watsonville, CA 95076
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Mission Drive Medical Office
$33 SF/Yr
2,676 SF

Mission Drive Medical Office

Santa Cruz medical office space available.

3321 Mission Dr, Santa Cruz, CA 95065
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Freedom Centre: Watsonville Retail
Contact for pricing
151,365 SF

Freedom Centre: Watsonville Retail

High-traffic retail space, multiple suites available.

0 Freedom Blvd. & Airport Blvd, Freedom, CA 95019
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Santa Cruz Restaurant - Lease Opportunity
$24 SF/Yr
18,809 SF

Santa Cruz Restaurant - Lease Opportunity

Historic Santa Cruz Restaurant Space Available

555 Soquel Ave, Santa Cruz, CA 95062
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Santa Cruz Office Space for Lease
$18 SF/Yr
11,826 SF

Santa Cruz Office Space for Lease

Prime Santa Cruz Office, 742 sq ft.

501 Mission St, Santa Cruz, CA 95060
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Santa Cruz Office Suites for Lease
$20 SF/Yr
7,000 SF

Santa Cruz Office Suites for Lease

Prime Santa Cruz location, flexible office spaces.

542 Ocean St, Santa Cruz, CA 95060
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High-Bay Flex Space, Santa Cruz
$15 SF/Yr
14,900 SF

High-Bay Flex Space, Santa Cruz

Rare R&D/Warehouse/Flex Space, Mt Hermon Rd

103 Whispering Pne Dr, Scotts Valley, CA 95066
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Linda Vista Shopping Center: Prime Retail Space
$48 SF/Yr
15,000 SF

Linda Vista Shopping Center: Prime Retail Space

Westside Santa Cruz retail center, 8 suites, space available.

2320 Mission St, Santa Cruz, CA 95060
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Watsonville Retail Space Available
Contact for pricing
3,070 SF

Watsonville Retail Space Available

Prime 3,070 sq ft retail space in thriving shopping center

1435 Main St, Watsonville, CA 95076
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Prime Santa Cruz County Flex Space
$15 SF/Yr
4,000 SF

Prime Santa Cruz County Flex Space

Rare 4,000+ sq ft flex space; freeway access.

103 Whispering Pne Dr, Scotts Valley, CA 95066
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Ground Floor Commercial Space Available
$1.70 SF/Yr
4,430 SF

Ground Floor Commercial Space Available

Commercial space for lease, formerly a bank, with ample parking.

3001 Thurber Ln, Santa Cruz, CA 95065
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Los Gatos Retail Space Available
Contact for pricing
1,972 SF

Los Gatos Retail Space Available

Grocery anchored shopping center with spaces for rent.

15537-15555 Union Ave, Los Gatos, CA 95032
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Los Gatos Retail Space
Contact for pricing
1,025 SF

Los Gatos Retail Space

Retail space in prime Silicon Valley location.

23 University Ave, Los Gatos, CA 95030
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Retail Space Near Highway 17
Contact for pricing
2,665 SF

Retail Space Near Highway 17

Retail space for lease near Highway 17 in Los Gatos.

15662-15732 Los Gatos Blvd, Los Gatos, CA 95032
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Former Skilled Nursing Facility Available
Contact for pricing
6,399 SF

Former Skilled Nursing Facility Available

28-bed skilled nursing facility with outdoor area for rent.

16601 Lark Ave, Los Gatos, CA 95032
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Downtown Santa Cruz Retail Space
$3 SF/Yr
4,622 SF

Downtown Santa Cruz Retail Space

New retail space in mixed-use building, prime downtown location.

800 Pacific Ave, Santa Cruz, CA 95060
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Scotts Valley Warehouse Space Available
$1.15 SF/Yr
5,000 SF

Scotts Valley Warehouse Space Available

Warehouse space for lease with highway access and ample parking.

30 Janis Way, Scotts Valley, CA 95066
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Professional Office Space Available
$2.00 SF/Yr
555 SF

Professional Office Space Available

Well-maintained office building with separately metered suites for rent.

5321 Scotts Valley Dr, Scotts Valley, CA 95066
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Mixed-Use Development Retail Space
Contact for pricing
1,744 SF

Mixed-Use Development Retail Space

Retail space in a mixed-use development with residential units.

418-508 Front St, Santa Cruz, CA 95060
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Retail Space in Watsonville
$12 SF/Yr
3,029 SF

Retail Space in Watsonville

Retail space available for lease in Watsonville, California.

1200 Main St, Watsonville, CA 95076
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Santa Cruz County, CA Commercial Real Estate Leasing Opportunities Market Analysis

Explore Commercial Real Estate leasing options in Santa Cruz County, CA with 208 listings featured on our commercial real estate exchange. The current inventory includes 18,001,736,280 square feet of properties with an estimated lease value of $1,112 /Mo.

Estimated lease rates for Commercial Real Estate in Santa Cruz County, CA begin at $1.15 SF/Yr, with an average of $15 SF/Yr and extend to $48 SF/Yr.

In Santa Cruz County, CA, current lease rates show:

  • Office Properties & Spaces positioned at $15
  • Office space measuring $15
  • Retail properties assessed at $16
  • Individual retail properties calculated at $15
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