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Salem County, VA Office Properties & Spaces for Sale

32 results
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Franklin Road Office/Retail Opportunity
$1,350,000
1.00 Acre

Franklin Road Office/Retail Opportunity

4040 Franklin Rd SW, Roanoke, VA 24014

Prime commercial land on Franklin Road with high traffic volume.

  • High‑visibility location on Franklin Road/Route 220 with a VDOT daily traffic count of 32,000.
  • Suitable for office, medical, or retail use.
  • Includes 2 parcels totaling 1 acre.
  • Recently remodeled (less than 3 years ago).
  • Loading docks available.
Updated: Oct 5, 2025
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Roanoke Investment Opportunity
$545,000
0.31 Acres

Roanoke Investment Opportunity

414 9Th St SE, Roanoke, VA 24013

Well-maintained commercial building leased to the Commonwealth of Virginia.

  • Leased to the Commonwealth of Virginia, providing stable income.
  • 100% occupancy, ensuring immediate returns on investment.
  • Modern construction (built in 2005, updated in 2016) minimizing potential maintenance costs.
  • 4,645 SF building suitable for office use.
  • Abundant natural light from large storefront windows.
Updated: Nov 14, 2025
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Roanoke Office Building For Sale
$750,000
0.63 Acres

Roanoke Office Building For Sale

Traditional office building with on-site parking and corner location.

4533 Brambleton Ave, Roanoke, VA 24018
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Roanoke Office/Retail Building For Sale
$650,000
0.30 Acres

Roanoke Office/Retail Building For Sale

Office building with subdivision potential and ample parking.

356 Campbell Ave SW, Roanoke, VA 24016
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Historic Horton Building in Roanoke
$2,875,000
0.20 Acres

Historic Horton Building in Roanoke

Landmark building blending early-20th-century craftsmanship with modern functionality.

302 1St St SW, Roanoke, VA 24011
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Roanoke Office/Retail Ready For Business
$476,850
0.32 Acres

Roanoke Office/Retail Ready For Business

Well-appointed, updated office/retail space near interstate, airport, and downtown.

624-626 Abney Rd, Roanoke, VA 24012
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Multi-Tenant Professional Business Center
$1,750,000
12,000 SF

Multi-Tenant Professional Business Center

12,000 SF multi-tenant professional center with strong rental history.

192 Summerfield Ct, Roanoke, VA 24019
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Office Condo in McVitty Center
$205,000
1,205 SF

Office Condo in McVitty Center

Office condo with reception, offices, restrooms, and kitchenette for sale.

2774 Electric Rd Southwest | Roanoke, Roanoke, VA 24014
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High-Tech Manufacturing and Warehouse Facility
$10,750,000
146,852 SF

High-Tech Manufacturing and Warehouse Facility

Expandable manufacturing, office, and warehouse facility near I-581 and I-81.

2797 Frontage Rd - NW, Roanoke, VA
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Roanoke Office Building with Views
$1,300,000
10,129 SF

Roanoke Office Building with Views

10,129 SF office building with valley views for sale.

7851-7857 Enon Dr, Roanoke, VA 24019
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Multi-Tenant Office Building For Sale
$1,425,000
7,416 SF

Multi-Tenant Office Building For Sale

7,500 SF multi-tenant office building on 1.44 acres.

1618 W Main St, Salem, VA 24153
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Renovated Commercial Building in Roanoke
$319,000
1,200 SF

Renovated Commercial Building in Roanoke

Updated 1200 sq ft commercial space in Old Southwest Roanoke.

708 5Th St SW, Roanoke, VA 24016
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Six-Story Commercial Building in Roanoke
$2,600,000
32,445 SF

Six-Story Commercial Building in Roanoke

Six-story commercial building in downtown Roanoke with redevelopment opportunities.

302 S Jefferson St, Roanoke, VA 24011
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Modern Office Warehouse For Sale
$3,495,000
30,635 SF

Modern Office Warehouse For Sale

Class A office warehouse building with excellent location and condition.

442 Rutherford Ave NE | Roanoke, Roanoke, VA 24016
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Roanoke Office Building For Sale
$675,000
5,553 SF

Roanoke Office Building For Sale

5,553 SF office building near downtown Roanoke.

656 Elm Ave SW, Roanoke, VA 24013
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Williamson Road Office Building
Contact for pricing
8,000 SF

Williamson Road Office Building

Office building with frontage on Williamson Road and existing leases.

5423 Williamson Rd, Roanoke, VA 24012
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Downtown Roanoke Office Building
$980,000
6,947 SF

Downtown Roanoke Office Building

6,947 SF office building in downtown Roanoke.

28 Church Ave SW, Roanoke, VA 24011
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Well-Maintained Office Space For Sale
$695,000
4,312 SF

Well-Maintained Office Space For Sale

4,312 sq ft office space in high-traffic location.

5335 Peters Creek Rd NW, Roanoke, VA 24019
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Modern Office Warehouse Building
$3,790,000
30,635 SF

Modern Office Warehouse Building

30,635 SF office warehouse for sale near downtown Roanoke.

442 Rutherford Ave - NE, Roanoke, VA
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South Roanoke Office/Medical Building For Sale
$1,750,000
6,631 SF

South Roanoke Office/Medical Building For Sale

Office or medical building near Carilion Roanoke Memorial Hospital.

301 Mc Clanahan St SW, Roanoke, VA 24014
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Corner Retail/Office Opportunity
$365,000
2,377 SF

Corner Retail/Office Opportunity

2,377 sq ft brick building on 0.18 acres.

5005 Williamson Rd NW, Roanoke, VA 24012
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Warehouse Flex Space For Sale
$495,000
9,000 SF

Warehouse Flex Space For Sale

Warehouse flex space with office near Downtown Roanoke.

1415 Cleveland Ave SW, Roanoke, VA 24016
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Roanoke Office Building For Sale
$1,950,000

Roanoke Office Building For Sale

Centrally located office building with CG zoning in Roanoke.

1917 Franklin Rd, Roanoke, VA 24014
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Office Building Near Publix
$990,000
8,934 SF

Office Building Near Publix

Office building in high-visibility commercial corridor, near upcoming Publix.

4519 Brambleton Ave, Roanoke, VA 24018
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Salem County, VA Office Properties & Spaces Investment Opportunities Market Analysis

Explore 43 office properties & spaces for sale in Salem County, VA, showcased through 32 active listings on our real estate platform. These investment opportunities span a total of 136,300 square feet of properties for sale, with an estimated market value of $7,026,850.

Prices for office spaces in Salem County, VA start at $110,000, averaging $878,356, and reaching up to $2,875,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you have the most current data.

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