Tuscumbia, AL Office Spaces for Sale

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Sheffield, AL Cherokee, AL Muscle Shoals, AL Rainbow City, AL Florence, AL Leighton, AL Russellville, AL Gadsden, AL

Updated: Dec 4, 2025

Warehouse with Finished Office Area

300 W 5th Street, Tuscumbia, AL 35674

$225,000

8,679 sqft 0.53 AC lot

8,054 SF open warehouse space with clear floor space and good ceiling height
625 SF finished office area for administrative use
Wide access for equipment or inventory plus easy truck access
On‑site parking for staff and customers
0.53‑acre lot

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Updated: Sep 22, 2025

Corner-Lot Medical Office

300 E 6th St, Tuscumbia, AL 35674

$224,900

1,500 sqft 0.50 AC lot

1,500‑square‑foot medical office on a 0.5‑acre corner lot
Reception area with private offices or exam rooms
Kitchen and breakroom plus bathroom
Parking, carport, patio, and security system
00 Commercial zoning designation

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Four-Building Mixed-Use Property

1460 Highway 20, Tuscumbia, AL 35674

Contact for pricing

23,000 sqft 11.60 AC lot

Office, warehouse, and light-industrial buildings occupy a level site with dual access drives.

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Mixed-Use Commercial Property For Sale

5910 Hwy 43, Tuscumbia, AL 35674

$280,000

2,733 sqft

Mixed-use property with commercial, residential, and storage spaces.

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Medical Office Support Center

110 E 5th St, Tuscumbia, AL 35674

Contact for pricing

Finished lower-level space and a long-term absolute NNN lease support the property’s medical-office configuration.

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Based on your search, we've compiled 80 Potential Opportunities for your consideration. Besides 5 Active listings in Tuscumbia, AL, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 67 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Medical and Office Building

1021 Woodward Ave, Muscle Shoals, AL 35661

$447,200

3,440 sqft

Office building on Woodward Avenue with strong visibility and convenient access for a range of service uses.

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Medical Office Building with Rear Parking

1207 S Montgomery Ave S, Sheffield, AL 35660

$149,900

2,320 sqft 0.14 AC lot

Medical office property with commercial zoning, two bathrooms, and rear access for parking.

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Office and Medical Building

1001 S. Jackson HWY, Sheffield, AL 35660

Contact for pricing

Office and medical building with 2019 HVAC, included equipment, and ample parking near major healthcare.

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Office Building with Dual Access

3400 Woodward Ave., Muscle Shoals, AL 35661

Contact for pricing

Access is available from both Woodward Avenue and 6th Street.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Tuscumbia Commercial Property on Frankfort

726 Frankfort Rd, Tuscumbia, AL 35674

$209,000

2,530 sqft 2.94 AC lot

2.94 acre commercial property with 2500+ sqft space.

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Commercial Land in Tuscumbia, AL

Gargis Ln, Tuscumbia, AL 35674

$60,000

0.50 AC lot

Commercial property near Highway 20 with business venture potential.

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Commercial Land in Tuscumbia, AL

Gargis Ln, Tuscumbia, AL 35674

$60,000

0.50 AC lot

Commercial property near Highway 20 with business venture potential.

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Commercial Land on Highway 20

Gargis Ln, Tuscumbia, AL 35674

$399,000

1.00 AC lot

Commercial property with frontage on Highway 20 in Tuscumbia, AL.

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Off-Market Properties in Tuscumbia, AL

Consider similar Off-Market properties in Tuscumbia, AL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

MEDICAL BUILDING

130 Keller Park Blvd, Tuscumbia, AL 35674-1416

$300,000

Estimated value

3,303 sqft 0.35 AC lot

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MEDICAL BUILDING

6th St, Tuscumbia, AL 35674

$2,310,000

Estimated value

8,064 sqft

View details

OFFICE (GENERAL)

110 2nd St, Tuscumbia, AL 35674-2012

$130,000

Estimated value

1,949 sqft

View details

OFFICE (GENERAL)

106 5th St, Tuscumbia, AL 35674-2412

$85,000

Estimated value

2,835 sqft

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OFFICE (GENERAL)

509 Main St, Tuscumbia, AL 35674-2048

$205,000

Estimated value

4,343 sqft 0.35 AC lot

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OFFICE (GENERAL)

304 Water St, Tuscumbia, AL 35674-1928

$85,000

Estimated value

1,207 sqft 0.09 AC lot

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OFFICE (GENERAL)

Dickson St, Tuscumbia, AL 35674

$90,000

Estimated value

1,405 sqft 0.50 AC lot

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OFFICE (GENERAL)

Main St, Tuscumbia, AL 35674

$105,000

Estimated value

1,500 sqft

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OFFICE (GENERAL)

5th St, Tuscumbia, AL 35674

$55,000

Estimated value

1,873 sqft

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OFFICE (GENERAL)

2nd St, Tuscumbia, AL 35674

$435,000

Estimated value

6,629 sqft 0.31 AC lot

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MEDICAL BUILDING

121 5th St, Tuscumbia, AL 35674-2409

$1,785,000

Estimated value

4,956 sqft

View details

OFFICE (GENERAL)

505 Main St, Tuscumbia, AL 35674-2048

$165,000

Estimated value

5,524 sqft 0.26 AC lot

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OFFICE (GENERAL)

Dickson St, Tuscumbia, AL 35674

$135,000

Estimated value

1,302 sqft

View details

MEDICAL BUILDING

208 5th St, Tuscumbia, AL 35674-2520

Value Estimation by Request

1,100 sqft 0.06 AC lot

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OFFICE (GENERAL)

106 6th St, Tuscumbia, AL 35674-2414

$400,000

Estimated value

8,959 sqft

View details

OFFICE (GENERAL)

Tuscumbia, AL 35674

$135,000

Estimated value

1,705 sqft 2.52 AC lot

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OFFICE (GENERAL)

201 Water St, Tuscumbia, AL 35674-1926

$175,000

Estimated value

3,876 sqft

View details

MEDICAL BUILDING

1309 State St, Tuscumbia, AL 35674-1772

Value Estimation by Request

4,012 sqft

View details

OFFICE (GENERAL)

6th St, Tuscumbia, AL 35674

$140,000

Estimated value

1,446 sqft

View details

Tuscumbia, AL Office Spaces Market Trends and Statistics

Explore 72 office spaces for sale in Tuscumbia, AL, showcased through 5 active listings on our real estate platform. These investment opportunities span a total of 35,912 square feet of properties for sale, with an estimated market value of $729,900.

Sale prices for office spaces in Tuscumbia, AL start at $224,900, averaging $243,300, and reaching up to $280,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Top Commercial Asset Segments

Commercial property segments ranked by active listings on the market

Demographics Overview

Population 20K

Population Growth (5Y) +9.6%

Median Household Income $56,960

College Educated 30.9%

High-Yield Neighborhoods for Investment

Identify Tuscumbia submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
35674	$243.3K

Taxes & Financing

Tax Rate (average for all types) 3.78%

Property Tax per SF $71.84 per SF

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in Colbert County

New Delisted

Total CRE Inventory on Market (SF)

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Tuscumbia, AL Office Spaces for Sale

300 W 5th Street, Tuscumbia, AL 35674

300 E 6th St, Tuscumbia, AL 35674

1460 Highway 20, Tuscumbia, AL 35674

5910 Hwy 43, Tuscumbia, AL 35674

110 E 5th St, Tuscumbia, AL 35674

Opportunities in Nearby Cities

1021 Woodward Ave, Muscle Shoals, AL 35661

1207 S Montgomery Ave S, Sheffield, AL 35660

1001 S. Jackson HWY, Sheffield, AL 35660

3400 Woodward Ave., Muscle Shoals, AL 35661

Potential Development Sites for Consideration

726 Frankfort Rd, Tuscumbia, AL 35674

Gargis Ln, Tuscumbia, AL 35674

Gargis Ln, Tuscumbia, AL 35674

Gargis Ln, Tuscumbia, AL 35674

Off-Market Properties in Tuscumbia, AL

130 Keller Park Blvd, Tuscumbia, AL 35674-1416

6th St, Tuscumbia, AL 35674

110 2nd St, Tuscumbia, AL 35674-2012

106 5th St, Tuscumbia, AL 35674-2412

509 Main St, Tuscumbia, AL 35674-2048

304 Water St, Tuscumbia, AL 35674-1928

Dickson St, Tuscumbia, AL 35674

Main St, Tuscumbia, AL 35674

5th St, Tuscumbia, AL 35674

2nd St, Tuscumbia, AL 35674

121 5th St, Tuscumbia, AL 35674-2409

505 Main St, Tuscumbia, AL 35674-2048

Dickson St, Tuscumbia, AL 35674

208 5th St, Tuscumbia, AL 35674-2520

106 6th St, Tuscumbia, AL 35674-2414

Tuscumbia, AL 35674

201 Water St, Tuscumbia, AL 35674-1926

1309 State St, Tuscumbia, AL 35674-1772

6th St, Tuscumbia, AL 35674

Tuscumbia, AL Office Spaces Market Trends and Statistics

Top Commercial Asset Segments

Demographics Overview

High-Yield Neighborhoods for Investment

Taxes & Financing

Listings Trend

Total CRE Inventory on Market (SF)

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