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    Winston-Salem, NC Office Spaces for Lease

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    Winston Salem, NC Kernersville, NC Walkertown, NC Rural Hall, NC Clemmons, NC High Point, NC Greensboro, NC Oak Ridge, NC
    23 properties
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    Class A Office Space Available
    Updated: Nov 22, 2025
    Class A Office Space Available

    100 North Main Street, Winston-salem, NC 27101

    Contact for pricing
    218,488 sqft
    Class A office space in a signature tower.
    Unparalleled amenities: enjoy the convenience of an on‑site cafeteria, fitness center, 24/7 security, and barber shop.
    Suites available for various tenant sizes.
    Convenient parking options include a garage and parking deck with secure access.
    Walking distance to Wake Forest Innovation Quarter, restaurants, hotels, arts, entertainment, and the courthouse.
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    Move-in Ready Medical Office Space
    Updated: Nov 24, 2025
    Move-in Ready Medical Office Space

    725 Highland Oaks Dr, Winston-salem, NC

    Contact for pricing
    3,864 sqft 2.32 AC lot
    Move‑in ready first floor medical office.
    Convenient location in medical park less than half mile from I‑40.
    Ample parking.
    Ideal for medical, wellness, or clinical practice.
    Building co‑tenants include Novant Health and Carolina Eye Associates.
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    Downtown Winston-Salem Office Space
    Downtown Winston-Salem Office Space

    500 West 5th Street, Winston-salem, NC 27101

    Contact for pricing
    4,000 sqft

    Prime office space in Winston-Salem's Central Business District.

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    Historic Building Retail/Office Space
    Historic Building Retail/Office Space

    500 W 4th St, Winston-salem, NC

    Contact for pricing
    7,400 sqft 0.98 AC lot

    Redeveloped historic building offering retail and office space for lease.

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    Suburban Office Space Available
    Suburban Office Space Available

    3410 Healy Dr, Winston-salem, NC

    Contact for pricing
    521 sqft 1.93 AC lot

    Office space for rent in convenient location near I-40.

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    Two-Story Office Building For Rent
    Two-Story Office Building For Rent

    3288 Robinhood Road, Winston-salem, NC 27106

    Contact for pricing
    1,932 sqft

    Two-story office building with on-site parking in convenient location.

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    Hanes Mall Corridor Office Sublease
    Hanes Mall Corridor Office Sublease

    799 Hanes Mall Boulevard, Winston-salem, NC 27103

    Contact for pricing
    101,555 sqft

    Office sublease in desirable Hanes Mall corridor with easy access.

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    Office Space Near Retail Market
    Office Space Near Retail Market

    1495 Rymco Dr, Winston-salem, NC

    Contact for pricing
    856 sqft 0.68 AC lot

    Office space in Winston-Salem's prime retail location.

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    Renovated Office Building For Rent
    Renovated Office Building For Rent

    601 West 4th Street, Winston-salem, NC 27101

    Contact for pricing
    1,474 sqft

    Completely renovated two-story office building in Winston Salem CBD.

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    Class A Office Space Available
    Class A Office Space Available

    370 Knollwood St, Winston-salem, NC

    Contact for pricing
    1,951 sqft 4.79 AC lot

    Class A office building with on-site amenities and prime location.

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    Flexible Workspace Solutions at St. George Square. Contact us today to book a tour!
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    Well-Maintained Office Space Available
    Well-Maintained Office Space Available

    1321 Westbrook Plaza Dr, Winston-salem, NC

    Contact for pricing
    1,660 sqft 1.15 AC lot

    Office space near retail corridor with significant natural light.

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    Winston-Salem Office Space Available
    Winston-Salem Office Space Available

    125 Jonestown Rd, Winston-salem, NC

    Contact for pricing
    1,600 sqft 4.03 AC lot

    Office suites available with high visibility and traffic counts.

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    Warehouse with Office and Frontage
    Warehouse with Office and Frontage

    3425 Thomasville Rd, Winston-salem, NC 27107

    Contact for pricing
    22,000 sqft

    22,000 SF warehouse with office space and road frontage.

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    Class A Office Building
    Class A Office Building

    2025 Frontis Plaza Blvd, Winston-salem, NC

    Contact for pricing
    14,395 sqft 3.01 AC lot

    Four-story Class A office building near Hanes Mall Boulevard.

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    Westbrook Plaza Office Suites Available
    Westbrook Plaza Office Suites Available

    1321 Westbrook Plaza Dr, Winston-salem, NC 27103

    Contact for pricing
    2,016 sqft

    Office suites for lease near Winston-Salem's retail corridor.

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    Historic Office Space For Lease
    Historic Office Space For Lease

    426 Old Salem Rd, Winston-salem, NC 27101

    Contact for pricing

    Office space in historic building near Old Salem and downtown.

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    Office Space For Rent
    Office Space For Rent

    1373 Westgate Center Dr, Winston-salem, NC

    Contact for pricing
    1,500 sqft 0.50 AC lot

    Office space available with ample parking and TIA.

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    Class A Office Retail Complex
    Class A Office Retail Complex

    380 Knollwood St, Winston-salem, NC 27103

    Contact for pricing
    136,976 sqft 4.75 AC lot

    Seven-story Class A office building with retail and office spaces.

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    Winston-Salem Class B Office Building
    Winston-Salem Class B Office Building

    514 S Stratford Rd, Winston-salem, NC 27103

    Contact for pricing
    60,000 sqft 2.49 AC lot

    Four-story office building with flexible space and ample parking.

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    Downtown Winston-Salem Office Space
    Downtown Winston-Salem Office Space

    530 N. Trade Street, Winston-salem, NC 27101

    Contact for pricing
    4,197 sqft

    Class A office space in downtown Winston-Salem's Traders Row.

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    Winston-Salem Suburban Office Suites
    Winston-Salem Suburban Office Suites

    3410 Healy Dr, Winston-salem, NC 27103

    Contact for pricing
    1,158 sqft

    Flexible and affordable office suites in a convenient Winston-Salem location.

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    Office Space Near Hanes Mall
    Office Space Near Hanes Mall

    1605 Westbrook Plaza Dr, Winston-salem, NC 27103

    Contact for pricing

    Office space for lease with convenient access to I-40.

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    Based on your search, we've compiled 28 Potential Opportunities for your consideration. Besides 23 Active listings in Winston-Salem, NC, we suggest exploring alternatives. Similar 5 Properties for Sales.

    Similar Spaces for Sale in Winston-Salem, NC

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    Winston-Salem Office Space Available
    Winston-Salem Office Space Available

    3305 Stockton St, Winston-salem, NC

    Contact for pricing
    5,011 sqft 0.70 AC lot

    Office space available for lease in Winston-Salem, North Carolina.

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    Winston-Salem, NC Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in Winston-Salem, NC with 23 listings featured on our commercial real estate exchange. The current inventory includes 589,654 square feet of properties with an estimated lease value of $24,428.

    Estimated lease rates for Office Spaces in Winston-Salem, NC begin at $129/Mo, with an average of $12,214/Mo and extend to $24,299/Mo.
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    Most Searched ZIP Codes in Winston-Salem, NC

    • 27103
    • 27101
    • 27106
    • 27107

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