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Southampton, MA Office Spaces for Lease

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Westfield, MA Easthampton, MA Holyoke, MA West Springfield, MA Russell, MA Chicopee, MA South Hadley, MA Northampton, MA
Medical Office Building with Deck
Updated: Nov 6
Medical Office Building with Deck

376 College Highway, Southampton, MA 01073

$20 SF/Yr
3,965 sqft
3,965‑square‑foot building constructed in 1920
Multiple private offices, reception, waiting area, and conference room
Handicap accessible with 25 on‑site parking spaces
Kitchen space, restrooms, and deck
Located on College Highway (Route 10), near Interstate 91 and the Massachusetts Turnpike
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1 active listing matches your search: Office for lease in Southampton, MA. Based on your search, we've also compiled 7 Potential Opportunities for your consideration: 4 spaces in nearby cities, 2 properties for sale, and 1 land listing with development potential.

Office Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Industrial Space Available For Lease
Industrial Space Available For Lease

22 Progress Avenue, Westfield, MA 01085

$6.95 SF/Yr
50,000 sqft

50,000 SF industrial space for lease in Westfield.

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Ingleside Professional Center Office Suite
Ingleside Professional Center Office Suite

40 Bobala Rd, Holyoke, MA 01040

$20 SF/Yr
3,750 sqft  Built 1995  5.18 acres

First floor office/medical suite for lease near I-91.

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Versatile Second Floor Space
Versatile Second Floor Space

501 Southampton Road, Westfield, MA 01085

$11 SF/Yr
10–16 people  2,500 sqft  Built 2012

Adaptable 2,200-2,800 SF space with Mass Pike access.

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Office Space in Holyoke, MA
Office Space in Holyoke, MA

36-40 Bobala Rd, Holyoke, MA

Contact for pricing
15–25 people  1 space  3,750 sqft  4.97 acres

Office space for lease in Holyoke, Massachusetts.

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Similar Spaces for Sale in Southampton, MA

Consider Similar Space for Sale. We found 2 Spaces matching your search parameters.

Office Building with Deck
Office Building with Deck

376 College Hwy, Southampton, MA 01073

Contact for pricing
3,965 sqft

The interior includes reception, conference, waiting, kitchen, and private office areas, with accessible entry and on-site parking.

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Office Building with Additional Land
Office Building with Additional Land

241 College Hwy, Southampton, MA 01073

$950,000

Flexible office configuration with a kitchen, garage, on-site parking, and expansion capacity from adjoining land.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

6.79 Acres on Merrow Road
6.79 Acres on Merrow Road

248 Merrow Rd, Tolland, CT 06084

Contact for pricing
6.79 acres

Commercial land with ranch home in technology campus zone.

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Southampton, MA Office Spaces Lease Rates & Market Statistics

Browse 1 Office Spaces listing for lease in Southampton, MA on Realmo, a commercial real estate marketplace serving the Southampton area. The current inventory totals 3,965 square feet of properties.

Office Spaces lease rates in Southampton range from $20 SF/Yr at the entry level to $20 SF/Yr at the top of the market, averaging $20 SF/Yr. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. At $20 SF/Yr, the local average runs 29% below Massachusetts's state average of $28.35 SF/Yr.

Southampton accounts for 1% of the 85 office spaces currently available across Hampshire County, where nearby markets include Northampton and Amherst.

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Demographics Overview

Population 6,212
Population Growth (5Y) +1.2%
Median Household Income $125,534
College Educated 56.0%

Office Vacancy Rate

Office vacancy in Northeast region stood at 19.9% in 2025, up from 13.1% in 2019. Figures are for Northeast region, not for Southampton.

Office Space by Type

The largest space type in Southampton, MA is Medical Office Space, with 1 listings.

Medical Office Space 1 Office Units 1

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