Monroe County, IL Office Spaces for Rent & Lease

Updated: Nov 17, 2025

Basement Office Unit with Utilities Included

207 N Main Basement Unit B Street N, Columbia, IL 62236

$525/Mo

14,000 sqft 0.41 AC lot

Basement office unit B in a brick commercial building
Water, sewer, trash, and heating/cooling included in rent
One‑year lease term
Forced air heating plus central air cooling
Property on 0.41‑acre lot with 14,000 SF building

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Updated: Mar 10

Medical Office Suites Available

509 Hamacher St, Waterloo, IL 62298

Contact for pricing

5,384 sqft

Class A medical office suites available
Features an imaging center
Available space: 1,112 to 5,384 SF
Located in Waterloo, IL
Built in 1995

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Move-in Ready Suites For Lease

302-306 Southport Dr, Columbia, IL

Contact for pricing

1,525 sqft 4.56 AC lot

Premium suites suitable for retail, office, or medical applications.

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Move-in Ready Suites For Lease

310-314 Southport Dr, Columbia, IL

Contact for pricing

1,525 sqft 4.56 AC lot

Premium suites suitable for retail, office, or medical applications.

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Based on your search, we've compiled 11 Potential Opportunities for your consideration. Besides 4 Active listings in Monroe County, IL, we suggest exploring alternatives. Similar 7 Properties for Sales.

Similar Spaces for Sale in Monroe County, IL

Consider Similar Space for Sale. We found 7 Spaces matching your search parameters.

Versatile Commercial Condo For Sale

284 Southwoods Ctr, Columbia, IL 62236

$115,000

900 sqft

900 SF commercial condo, tenant occupied, great investment opportunity.

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Tenant-Occupied Office Unit

282 Southwoods Ctr, Columbia, IL 62236

$115,000

900 sqft

Professional workspace with a half bathroom and abundant natural light.

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Office Condo with Natural Light

272 Southwoods Ctr, Columbia, IL 62236

$115,000

900 sqft

Well-maintained commercial condo with a practical layout, half bathroom, and convenient access within a business complex.

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Newly Renovated Downtown Commercial Building

216 N Main St, Columbia, IL 62236

$1,500,000

Newly renovated commercial building with a new roof, HVAC, and electrical system throughout.

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Tenant-Occupied Office Condo

284 Southwoods Drive, Columbia, IL 62236

$115,000

0.88 AC lot

Includes a half bathroom and natural light for daily office use.

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Tenant-Occupied Office Condo

282 Southwoods Drive, Columbia, IL 62236

$115,000

0.88 AC lot

Tenant-occupied office condo with natural light and a half bathroom.

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Office Condo with Natural Light

272 Southwoods Drive, Columbia, IL 62236

$115,000

0.88 AC lot

Brick office condo with a half bathroom and natural light in a business complex.

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Monroe County, IL Office Spaces Market Trends and Statistics

Explore Office Spaces leasing options in Monroe County, IL with 4 listings featured on our commercial real estate exchange. The current inventory includes 22,434 square feet of properties with an estimated lease value of $525.

Estimated lease rates for Office Spaces in Monroe County, IL average $525/Mo.