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    Brookline, MA
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    Brookline, MA Office Buildings for Lease

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    Historic Office Estate Setting
    Updated: May 8
    Historic Office Estate Setting

    280 Newton St, Brookline, MA 02445

    Contact for pricing
    9,000 sqft
    Built in 1863, the Brandegee House has supported religious, charitable, scientific, literary, and educational endeavors
    First‑floor space includes a museum paying homage to the estate’s history
    Set on the Brookline/Boston line, suited for nonprofit, administrative, and office users in Greater Boston
    Property features maintained gardens, a series of walled terraces, pools, a temple grove, and landscaping
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    Standalone Medical Office Building
    Updated: Oct 24, 2025
    Standalone Medical Office Building

    20 Kent St, Brookline, MA 02445

    Contact for pricing
    15,000 sqft
    Standalone medical and office building available for lease in Brookline, MA
    Fully customizable space for a variety of professional or healthcare needs
    Close to the Longwood Medical Area
    Convenient westbound Route 9 access for staff, clients, and patients
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    Brookline Medical/Office Building For Lease
    Brookline Medical/Office Building For Lease

    32 Kent St, Brookline, MA 02445

    Contact for pricing
    3,950 sqft

    3,950 SF medical/office building for lease in Brookline, MA.

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    Office Building with Garage Parking
    Office Building with Garage Parking

    1371 Beacon St, Brookline, MA 02446

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    6,374 sqft

    Office space in a convenient Brookline location with on-site property management and abundant garage parking.

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    Based on your search, we've compiled 12 Potential Opportunities for your consideration. Besides 4 Active listings in Brookline, MA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 4 Properties for Sales.

    Office buildings for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Restored Office Building with Elevator
    Restored Office Building with Elevator

    124 Brookside Ave, Jamaica Plain, MA 02130

    Contact for pricing
    3,333 sqft

    Restored brick-and-timber office building with exposed high ceilings, hardwood floors, new systems, and 7 parking spaces.

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    New Office Space in Boston
    New Office Space in Boston

    1325 Boylston Street, Boston, MA 02215

    Contact for pricing
    238,770 sqft

    238,770 SF office space designed for collaboration and innovation.

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    Boylston Street Office and Lab
    Boylston Street Office and Lab

    1001 Boylston Street, Boston, MA 02115

    Contact for pricing
    100,000 sqft

    Office and lab space with views in Back Bay.

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    Restored Office Building
    Restored Office Building

    128 BROOKSIDE AVENUE, Jamaica Plain, MA 02130

    Contact for pricing

    Restored brick-and-timber office building with high ceilings, hardwood floors, new elevator, and updated electrical, HVAC, and plumbing.

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    Similar Spaces for Sale in Brookline, MA

    Consider Similar Space for Sale. We found 4 Spaces matching your search parameters.

    Two-Building Medical Office Assemblage
    Two-Building Medical Office Assemblage

    20 Kent St, Brookline, MA 02445

    Contact for pricing
    15,000 sqft 0.62 AC lot

    Standalone medical/office building plus adjacent office-configured unit with 39 on-site parking spaces.

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    Brookline Commercial Development Opportunity
    Brookline Commercial Development Opportunity

    115 Dummer St, Brookline, MA 02446

    $8,900,000
    18,000 sqft

    Versatile 18,000+ sq ft commercial property near BU.

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    Freestanding Flex Space
    Freestanding Flex Space

    115 Dummer St, Brookline, MA 02446

    $8,900,000
    18,699 sqft

    Open-plan commercial property with private offices, conference rooms, a kitchen, and separate entrances.

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    Office Building For Sale
    Office Building For Sale

    824-826 Boylston Street, Brookline, MA 02467

    Contact for pricing
    16,000 sqft

    For sale office building totaling 16,000 square feet on Boylston Street in Brookline, MA.

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    Brookline, MA Office buildings Lease Rates & Market Statistics

    Browse 4 Office buildings for lease in Brookline, MA on Realmo, a commercial real estate marketplace serving the Brookline area. The current inventory totals 34,324 square feet of properties.

    Brookline accounts for 6% of the 69 office buildings currently available across Norfolk County, where nearby markets include Quincy and Needham. Office buildings are one of the more limited space types in Brookline, with just 4 listings currently available — a scarcity worth factoring into lease negotiations. Tenants comparing options may also consider Office Units (36 listings) and Medical Office Space (13 listings) elsewhere in the Brookline market.

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