Saint Helena Island, SC Mixed-use properties for sale

$1,450,000

6.98 Acres

St. Helena Island Commercial Property

1760 Sea Island Pkwy, Saint Helena Island, SC 29920

Commercial property in the heart of St. Helena Island.

Successful restaurant currently occupies the property, providing immediate income potential.
Zoned C4 Community Center Mixed Use, allowing for diverse development opportunities.
Acreage out back offers significant potential for expansion and future development.
Completely renovated with new metal roof, flooring, paint, and updated bathrooms.
Includes an outdoor covered porch, enhancing the property's appeal.

Updated: Jan 16

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$650,000

0.47 Acres

Highway 21 Mixed-Use Opportunity

2123 Sea Island Pkwy, Saint Helena Island, SC 29920

Versatile property with Hwy-21 frontage, suitable for various uses.

Prime Hwy‑21 frontage on Harbor Island with high visibility.
Versatile 3,520 SF three‑story building suitable for office, live‑work, residential, or short‑term rental use.
Gorgeous Lowcountry water and marsh views.
Proximity to Fripp Island, Harbor Island, and Dataw Island.
Includes a 1,000 SF utility shed and paved parking lot.

Updated: Dec 9, 2025

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Based on your search, we've compiled 6 Potential Opportunities for your consideration. Besides 2 Active listings in Saint Helena Island, SC, we suggest exploring several alternatives: 4 properties in Nearby Cities

Explore Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Commercial Property Near Downtown Beaufort

$3,000,000

1.48 Acres

Commercial Property Near Downtown Beaufort

Income-generating commercial property with apartments and retail near downtown Beaufort.

81 A Sea Is Pkwy, Beaufort, SC 29907

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Beaufort Commercial Property with Waterfront

$4,800,000

1.48 Acres

Beaufort Commercial Property with Waterfront

Commercial property with apartments, retail spaces, deep water access.

81 Sea Island Pkwy, Beaufort, SC 29907

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$789,000

0.12 Acres

Paris Avenue Mixed-Use Property

Renovated mixed-use property in historic Port Royal, South Carolina.

1503 Paris Ave, Port Royal, SC 29935

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$950,000

0.23 Acres

Prime Corner Lot in Port Royal

0.23-acre mixed-use parcel in vibrant Port Royal's T4-Urban Center.

1008 Paris Ave, Port Royal, SC 29935

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Saint Helena Island, SC Mixed-Use Properties Investment Opportunities Market Analysis

Explore 2 mixed-use properties for sale in Saint Helena Island, SC on our real estate platform. These investment opportunities span a total of 494,406 square feet of properties for sale, with an estimated market value of $2,529,000.

Prices for multi use buildings in Saint Helena Island, SC start at $429,000, averaging $843,000, and reaching up to $1,450,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you have the most current data.

Saint Helena Island, SC Mixed-use Properties for Sale

St. Helena Island Commercial Property

Commercial property in the heart of St. Helena Island.

Highway 21 Mixed-Use Opportunity

Versatile property with Hwy-21 frontage, suitable for various uses.

Explore Opportunities in Nearby Cities

Commercial Property Near Downtown Beaufort

Beaufort Commercial Property with Waterfront

Paris Avenue Mixed-Use Property

Prime Corner Lot in Port Royal

Saint Helena Island, SC Mixed-Use Properties Investment Opportunities Market Analysis

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