Saint Helena, SC Mixed-use properties for sale

Versatile Commercial Property on Highway 21

$595,000

3,520 SF

Versatile Commercial Property on Highway 21

2123 Sea Island Pkwy, Saint Helena Island, SC 29920

Mixed-use property with high visibility and flexible layout.

Prime Hwy‑21 frontage on Harbor Island with high visibility.
Versatile 3,520 SF three‑story building suitable for office, live‑work, residential, or short‑term rental use.
Gorgeous Lowcountry water and marsh views.
Proximity to Fripp Island, Harbor Island, and Dataw Island.
Includes a 1,000 SF utility shed and paved parking lot.

Updated: Feb 16

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$429,000

3.90 Acres

St. Helena Island Mixed-Use Land

785 Sea Island Pkwy, Saint Helena Island, SC 29920

3.9 acre mixed-use land with development potential.

Zoned for mixed‑use development (T2RC) including retail, office, residential, and limited light industrial.
Rear parcels zoned T2 Rural (T2R) for residential or agricultural use.
Excellent opportunity along Sea Island Parkway.
Convenient location with great visibility on Highway 21.
Easy access to Beaufort and Lady's Island.

Updated: Dec 29, 2025

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$1,450,000

6.98 Acres

St. Helena Island Commercial Property

Commercial property in the heart of St. Helena Island.

1760 Sea Island Pkwy, Saint Helena Island, SC 29920

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Based on your search, we've compiled 7 Potential Opportunities for your consideration. Besides 3 Active listings in Saint Helena, SC, we suggest exploring several alternatives: 4 properties in Nearby Cities

Explore Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Commercial Property Near Downtown Beaufort

$3,000,000

1.48 Acres

Commercial Property Near Downtown Beaufort

Income-generating commercial property with apartments and retail near downtown Beaufort.

81 A Sea Is Pkwy, Beaufort, SC 29907

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Beaufort Commercial Property with Waterfront

$4,800,000

1.48 Acres

Beaufort Commercial Property with Waterfront

Commercial property with apartments, retail spaces, deep water access.

81 Sea Island Pkwy, Beaufort, SC 29907

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$779,000

0.12 Acres

Historic Port Royal Mixed-Use Property

Renovated mixed-use property in historic Port Royal, South Carolina.

1503 Paris Ave, Port Royal, SC 29935

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$950,000

0.23 Acres

Prime Corner Lot in Port Royal

0.23-acre mixed-use parcel in vibrant Port Royal's T4-Urban Center.

1008 Paris Ave, Port Royal, SC 29935

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Saint Helena, SC Mixed-Use Properties Investment Opportunities Market Analysis

Explore 3 mixed-use properties for sale in Saint Helena, SC, showcased through 3 active listings on our real estate platform. These investment opportunities span a total of 494,406 square feet of properties for sale, with an estimated market value of $2,474,000.

Sale prices for multi use buildings in Saint Helena, SC start at $429,000, averaging $824,666, and reaching up to $1,450,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

Saint Helena, SC Mixed-use Properties for Sale

Versatile Commercial Property on Highway 21

Mixed-use property with high visibility and flexible layout.

St. Helena Island Mixed-Use Land

3.9 acre mixed-use land with development potential.

St. Helena Island Commercial Property

Explore Opportunities in Nearby Cities

Commercial Property Near Downtown Beaufort

Beaufort Commercial Property with Waterfront

Historic Port Royal Mixed-Use Property

Prime Corner Lot in Port Royal

Saint Helena, SC Mixed-Use Properties Investment Opportunities Market Analysis

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